Results 211 to 220 of about 33,377,036 (247)

The Systemic Lottery - A Field Observational Study on the Detection and Management of Acute Events in Care Homes. [PDF]

Scand J Caring Sci
Rudebeck TL, Nielsen D, Lassen AT, Andersen D, Østervang C.   +4 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Early clinical and hemodynamic outcomes of SAVR, Ozaki neocuspidization, and TAVI: A real-world observational study. [PDF]

Medicine (Baltimore)
Özçelik S, Eren S, Özdemir K, Peynirci F, Özden Y, Şensöz Y, Terzi S, Kayacioğlu İ.   +7 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Clinical characteristics and outcomes of acute liver failure in Vietnam: A prospective cross-sectional observational study. [PDF]

Medicine (Baltimore)
Nguyen LC, Hoang HT, Luu DT, Doan HT, Nguyen OT, Nguyen TT, Khuc TT, Nguyen HV, Bui TT, Nguyen NM, Nguyen TN, Le TP.   +11 more
europepmc   +1 more source

Search for risks of intravenous chemotherapy-induced severe neutropenia in solid cancers: A retrospective observational study. [PDF]

Medicine (Baltimore)
Zhang N, He A.
europepmc   +1 more source

Mantis Study Group newsletter

, 1996
Mantis Study Group.
core  

Thrombus Formation and Peripherally Inserted Central Catheter-Related Infection: A Retrospective Observational Study. [PDF]

Nurs Open
Bei X, Wei Q, Wu M, Kang C, Gao Y, Gao X.   +5 more
europepmc   +1 more source