Results 141 to 150 of about 1,427,616 (263)

Effects of the herbicide 2,4 D active ingredient and commercial formulations on the early life stages of the amphibian Physalaemus gracilis. [PDF]

Ecotoxicology
Bridi C, Felicioni G, Luterek JE, Baú IC, Chagas FB, Pompermaier A, Alves C, Hartmann PA, Hartmann M.   +8 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Evaluation of Deep Eutectic Solvents for Cryopreservation of the Fish Pathogen <i>Saprolegnia parasitica</i>. [PDF]

Methods Protoc
Delimar S, Šarić E, Cvjetko Bubalo M, Bielen A.   +3 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Tailoring Freeze-Drying for Starter Cultures Preservation: A Case Study with <i>Lactiplantibacillus plantarum</i>. [PDF]

Foods
Miecznikowski A, Wierzchowska K, Choińska R, Fabiszewska A.   +3 more
europepmc   +1 more source

STATISTICAL OBSERVATION ON OUR BLADDER TUMOR REGISTRY

The Japanese Journal of Urology, 1985
Masayuki Yokokawa, Iwao Fukui, Hideaki Sekine, Takumi Yamada, Akira Noro, Takeharu Negishi, Kazushige Hosoda, Tsuneo Kawai, Makoto Washizuka, Kunihiko Sakai, Takashi Saitoh, Fumio Ohwada, Kiyonobu Tari, Daisuke Ishiwata, Kaoru Oka, Toshiaki Sarada   +15 more
openaire   +3 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Efficacy and safety of thymosin combined with anticancer therapy for esophageal cancer: a systematic review and meta-analysis of randomized controlled trials. [PDF]

Front Immunol
Sun T, Zhao R, Zhang C, Shan X, Zhang Y, Zheng Y.   +5 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Effects of temperature on the life-history traits of <i>Myzus persicae</i> and its efficiency in transmitting potato virus Y (PVY) in potato crops. [PDF]

PeerJ
Sokame BM, Tonnang HEZ, Gamarra H, Carhuapoma P, Kreuze J, Johnson LR, Arab A, Armbruster PA, Villena OC.   +8 more
europepmc   +1 more source