Results 41 to 50 of about 24,783 (253)

Impact of Assimilating High‐Resolution Atmospheric Motion Vectors on Convective Scale Short‐Term Forecasts: 1. Observing System Simulation Experiment (OSSE)

Journal of Advances in Modeling Earth Systems, 2021
This research investigates to what extent the high‐spatiotemporal‐resolution Atmospheric Motion Vector (AMV) product derived from the new‐generation Geostationary Operational Environmental Satellites‐Series R can benefit convective‐scale data ...
Juan Zhao, Jidong Gao, Thomas A. Jones, Junjun Hu   +3 more
doaj   +1 more source

Generating Pseudo-Realistic Infrared Observations for Observing System Simulation Experiments

IEEE Access
Observing System Simulation Experiments (OSSEs) are essential for evaluating and designing remote sensing systems using synthetic observations. A key aspect of OSSEs is tuning observation errors, typically by comparing data assimilation (DA) statistics from real and synthetic observations. However, during instrument design, only limited specifications,
Isaac Moradi, Will McCarty, Nikki Privé
openaire   +2 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Assessing impacts of observations on ocean circulation models with examples from coastal, shelf, and marginal seas

Frontiers in Marine Science
Ocean observing systems in coastal, shelf and marginal seas collect diverse oceanographic information supporting a wide range of socioeconomic needs, but observations are necessarily sparse in space and/or time due to practical limitations.
Christopher A. Edwards, Pierre De Mey-Frémaux, Bàrbara Barceló-Llull, Guillaume Charria, Byoung-Ju Choi, George R. Halliwell, Lars R. Hole, Colette Kerry, Vassiliki H. Kourafalou, Alexander L. Kurapov, Andrew M. Moore, Baptiste Mourre, Baptiste Mourre, Paolo Oddo, Ananda Pascual, Moninya Roughan, Chafih Skandrani, Andrea Storto, Vassilios Vervatis, John L. Wilkin   +19 more
doaj   +1 more source

OSSE for a sustainable marine observing network in the Sea of Marmara [PDF]

Nonlinear Processes in Geophysics, 2018
An observing system simulation experiment (OSSE) is presented in the Sea of Marmara. A high-resolution ocean circulation model (FESOM) and an ensemble data assimilation tool (DART) are coupled.
A. Aydoğdu, A. Aydoğdu, A. Aydoğdu, T. J. Hoar, T. Vukicevic, J. L. Anderson, N. Pinardi, N. Pinardi, A. Karspeck, J. Hendricks, N. Collins, F. Macchia, E. Özsoy   +12 more
doaj   +1 more source

Observing System Simulation Experiments in the Marmara Sea

, 2018
Poster presented in Symposium for the legacy of Anna Trevisan in Bologna in Oct ...
Aydogdu, Ali, Hoar, Tim J., Vukicevic, Tomislava, L. Anderson, Jeffrey, Karspeck, Alicia, Danabasoglu, Gokhan, Pinardi, Nadia, Hendrics, Jonathan, Collins, Nancy, Macchia, Francesca   +9 more
openaire   +1 more source

Community Global Observing System Simulation Experiment (OSSE) Package (CGOP): Perfect Observations Simulation Validation [PDF]

Journal of Atmospheric and Oceanic Technology, 2018
AbstractThe simulation of observations—a critical Community Global Observing System Simulation Experiment (OSSE) Package (CGOP) component—is validated first by a comparison of error-free simulated observations for the first 24 h at the start of the nature run (NR) to the real observations for those sensors that operated during that period.
Sid-Ahmed Boukabara, Kayo Ide, Narges Shahroudi, Yan Zhou, Tong Zhu, Ruifang Li, Lidia Cucurull, Robert Atlas, Sean P. F. Casey, Ross N. Hoffman   +9 more
openaire   +1 more source

Parameter Sensitivity of the WRF–LETKF System for Assimilation of Radar Observations: Imperfect-Model Observing System Simulation Experiments [PDF]

Weather and Forecasting, 2020
AbstractSpecification of suitable initial conditions to accurately forecast high-impact weather events associated with intense thunderstorms still poses a significant challenge for convective-scale forecasting. Radar data assimilation has been showing encouraging results to produce an accurate estimate of the state of the atmosphere at the mesoscale ...
Maldonado, Paula Soledad, Ruiz, Juan Jose, Saulo, Andrea Celeste   +2 more
openaire   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source