Results 191 to 200 of about 25,432,868 (344)

NASA's Earth Observing System Data and Information System - EOSDIS

, 2011
This slide presentation reviews the work of NASA's Earth Observing System Data and Information System (EOSDIS), a petabyte-scale archive of environmental data that supports global climate change research. The Earth Science Data Systems provide end-to-end
Ramapriyan, Hampapuram K.
core  

Hurricane air-sea drag saturation and sea-state dependence revealed by surface drones. [PDF]

Sci Adv
Foltz GR, Zhang D, Looney LB, Chiodi AM, Zhang JA, Zhang C, Mazza E, Chi NH, Cokelet ED.   +8 more
europepmc   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

IMOS - Animal Tracking Facility - Acoustic Tracking - Quality Controlled Detections (2007 - ongoing)

Maintenance and Update Frequency: biannuallyStatement: Several factors including transmission collisions caused by multiple transmitters within range of the same receiver, environmental noise or historical duplicate transmitter IDs, can generate ...

core  

Observing forest biomass globally

, 2012
Terrestrial biomass is considered as an essential indicator for the monitoring of the Earth's ecosystem and climate. In recent years, many regional biomass datasets have been produced. These were obtained using a wide range of methods - from pure remote
Obersteiner, M., Schepaschenko, M., McCallum, I., Kraxner, F., Schmullius, C., See, L., Schill, C., Baccini, A., Schepaschenko, D., Perger, C., Kindermann, G., Fritz, S., Santoro, M., Shvidenko, A., Gallaun, H., Saatchi, S.   +15 more
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Synthesis and Assimilation Systems - Essential Adjuncts to the Observing System

, 2009
Assimilation systems synthesize diverse in-situ and satellite data streams into full four-dimensional state estimates by combining the strengths of each data set and also of the model. The resulting analysis provides an integrated view of the information
Rienecker, Michele M., Lee, Tong
core  

Probing the habitual and compulsive-like basis of (dys)functional checking in the Observing Response Task, a rodent analogue relevant to obsessive-compulsive disorder. [PDF]

Psychopharmacology (Berl)
Pickenhan L, Milton AL.
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Chemotherapy-Induced Toxicities in Pediatric Cancer Patients in Tanzania [Letter]. [PDF]

Drug Healthc Patient Saf
Mwita S.
europepmc   +1 more source