Results 31 to 40 of about 1,213,388 (251)

Obsessive Compulsive Treatment Efficacy Trial (OCTET) comparing the clinical and cost effectiveness of self-managed therapies: study protocol for a randomised controlled trial [PDF]

, 2014
Background - UK National Institute of Health and Clinical Excellence guidelines for obsessive compulsive disorder (OCD) specify recommendations for the treatment and management of OCD using a stepped care approach.
Barkham, Michael, Arundel, Catherine, O'Leary, Neil, Lovell, Karina, Byford, S., Gellatly, J., Reynolds, S., Byford, Sarah, Gellatly, Judith, Rebecca Pedley, Sarah Byford, Connell, Janice, Peckham, E., Jo Molle, Lovell, K., Mottram, P., Gilbody, Simon, Bower, P., Patricia Mottram, Emily Peckham, Bower, Peter; id_orcid, McMillan, D., Gilbody, S., Janice Connell, Barkham, M., Molle, J., Reynolds, Shirley, Lovell, Karina; id_orcid, Dean McMillan, Karina Lovell, Pedley, R., Simon Gilbody, McMillan, Dean, Hardy, Gillian, Penny Bee, Catherine Arundel, Shirley Reynolds, Roberts, C., Gega, L., Nicola Lidbetter, Gellatly, Judith; id_orcid, Peter Bower, Bower, Peter, Christopher Roberts, O’Leary, Neil, O'Leary, N., Bee, Penny, Bee, Penny; id_orcid, Pedley, Rebecca; id_orcid, Lidbetter, Nicola, Bee, P., Lina Gega, Mottram, Patricia, Lidbetter, N., Michael Barkham, Hardy, G., Gega, Lina, Connell, J., Molle, Jo, Judith Gellatly, Roberts, Christopher, Peckham, Emily, Gillian Hardy, Neil O’Leary, Arundel, C., Pedley, Rebecca   +65 more
core   +2 more sources

Development and initial validation of the Obsessive Beliefs Questionnaire and the Interpretation of Intrusions Inventory

, 2001
In 1995 the Obsessive Compulsive Cognitions Working Group initiated a collective process to develop two measures of cognition relevant to current cognitive-behavioural models of OCD. An earlier report (Behav. Res.
SANAVIO, EZIO, OBSESSIVE COMPULSIVE COGNITIONS WORKING GROUP   +1 more
core   +2 more sources

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

What checkers actually check: an eye tracking study of inhibitory control and working memory [PDF]

, 2012
<p>Background - Not only is compulsive checking the most common symptom in Obsessive Compulsive Disorder (OCD) with an estimated prevalence of 50–80% in patients, but approximately ~15% of the general population reveal subclinical checking ...
Kessler Klaus, Harkin, B., Kessler, K., Harkin Ben, Miellet, Sebastien, Klaus Kessler, Harkin, Ben, Kessler, Klaus, Ben Harkin, Miellet Sebastien, Sebastien Miellet, Miellet, S.   +11 more
core   +1 more source

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

Advanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li, Ying‐Dan Zhang, Wei Wang, Xin‐Yi Wu, Di Li, Xin Gong, Fei Tian, Meng‐Yu Dai, Jian Gao, Zi‐Feng Zheng, Zi‐Yang Bi, Dong‐Dong Shi, Zhen Wang   +12 more
wiley   +1 more source

Characteristics Associated With Persistent Long COVID Symptoms in Healthcare Personnel Infected With SARS‐CoV‐2 Between August 2022 and May 2024: A Multicenter Cohort Analysis of US Healthcare Personnel

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Background Long COVID affects a significant proportion of COVID‐19 survivors. This study examined persistent Long COVID symptoms among healthcare personnel (HCP) and evaluated associations with vaccination, prior SARS‐CoV‐2 infection, underlying health conditions, and demographics.
Eric Kontowicz, Amanda K. Irish, Lilly C. Lee, Howard A. Smithline, Ian D. Plumb, Melissa Briggs‐Hagen, Alexandra F. Rollins, Karisa K. Harland, Anusha Krishnadasan, Karin F. Hoth, Eliezer Santos‐León, David A. Talan, Nicholas M. Mohr, Project PREVENT Network   +13 more
wiley   +1 more source

Cerebellar Abnormalities in the Neuroimaging Spectrum of CLTC‐Related Disorder

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Pathogenic variants in CLTC, which encodes the clathrin heavy chain involved in vesicle‐mediated trafficking in neurons, cause a rare neurodevelopmental disorder associated with variable severity of global developmental delay and intellectual disability and structural brain abnormalities. Although corpus callosum and white matter anomalies are
Daniel Charouf, Andrea Accogli, Fadi F. Hamdan, Francesca Nardecchia, Toshiyuki Itai, Kenneth A. Myers, Christine Saint Martin, Myriam Srour   +7 more
wiley   +1 more source

Obsessive-compulsive disorder in a patient with SCA type 1 [PDF]

, 2019
For many years, the cerebellum was thought to be only responsible for balance, movement, planning and execution. Nowadays, it is well accepted that most cerebellar connections are involved in non-motor functions. Herein, we provide a case report in which
Lourenço, Charles Marques, Ataliba, Gabriela Santana, Charles Marques Lourenço, Fernando Machado Vilhena Dias, Mesquita, Leonardo Mendes, Dias, Fernando Machado Vilhena, Gabriela Santana Ataliba, Leonardo Mendes Mesquita   +7 more
core   +1 more source

Younger versus older children with obsessive-compulsive disorder: Symptoms, severity and impairment

, 2021
Studies on child and adolescent obsessive-compulsive disorder (OCD) indicate that symptom severity is similar across age, but significant age differences of symptom profile and comorbid disorders have been observed.
Smárason, Orri, Thomsen, Per Hove, Tord Ivarsson, Hojgaard, David R.M.A., Nissen, Judith Becker, Nor Christian Torp, Weidle, Bernhard, Gudmundur Skarphedinsson, Bernhard Weidle, David R.M.A. Hojgaard, Torp, Nor Christian, Skarphedinsson, Gudmundur, Ivarsson, Tord,, Judith Becker Nissen, Orri Smárason, Per Hove Thomsen   +15 more
core   +1 more source

Heterozygous Variants in LRP1 Cause a Neurodevelopmental Disorder With Congenital Heart Defects

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT LRP1 encodes the low‐density lipoprotein (LDL) receptor‐related protein 1 (LRP1), a transmembrane protein involved in endocytosis and activation of multiple signaling pathways. LRP1 variants have been implicated in the pathogenesis of congenital heart defects (CHD), Alzheimer's disease, and neurodevelopmental disorders (NDD).
Alyssa L. Rippert, Gudny Anna Arnadottir, Laura Bedinger, Nicola Brunetti‐Pierri, Jennifer Cech, Xin Chen, Yanmin Chen, Erika Chick, Sarah Dyack, Madeleine Franchi, Tanja Frey, David Genevieve, Ian Glass, Jorge Granadillo, Kelly A. Keener, Sara B. MacKay, Paige McDunnah, Vinod K. Misra, Kristin G. Monaghan, Sureni V. Mullegama, Cristina Peduto, Leia Peterman‐Prather, Anita Rauch, Cherith Somerville, Kari Stefansson, Katharina Steindl, Patrick Sulem, Telma Sulem, Pamela Trapane, Roberta Zeuli, Samuel Zinner, Kosuke Izumi   +31 more
wiley   +1 more source