Results 41 to 50 of about 348,423 (344)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Postpartum Blood Loss in COVID-19 Patients—Propensity Score Matched Analysis

Biomedicines, 2022
The aim of this study was to compare the estimated blood loss and the frequency of obstetric hemorrhage among pregnant women with and without COVID-19 infection.
Marcin Januszewski, Małgorzata Santor-Zaczyńska, Laura Ziuzia-Januszewska, Michał Kudan, Alicja A. Jakimiuk, Waldemar Wierzba, Artur J. Jakimiuk   +6 more
doaj   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Sphenopalatine ganglion block for treatment of post-dural puncture headache in obstetric patients: An observational study

Indian Journal of Anaesthesia, 2018
Background and Aims: Post-dural puncture headache (PDPH) is a consequence of spinal and epidural anaesthesia in approximately 1% of obstetric patients. The gold standard for its treatment is epidural blood patch.
Nitu Puthenveettil, Sunil Rajan, Anish Mohan, Jerry Paul, Lakshmi Kumar   +4 more
doaj   +1 more source

Emergencies in Covid 19 Parturients: Anesthesia Concerns and Lessons Learnt

Archives of Anesthesia and Critical Care, 2021
Obstetric emergencies have always put the anaesthetist on nerves. More so in this era of novel coronavirus pandemic managing obstertric cases in emergency has been a diverse challenge.
Neha Amey Panse, Kavita Udaykumar Adate, Ketki Annasaheb Maske, Nidhi Rajesh Dabral   +3 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Unveiling paramedic confidence: exploring paramedics' perceived confidence in out-of-hospital births and obstetric emergencies - a scoping review

Rural and Remote Health
Introduction: The centralisation of birthing care, driven by the closure of 225 of Australia's rural birthing centres over the past 20 years, has resulted in a 47% increase in births before arrivals at hospitals. This shift positions paramedics as
Larissa Martin, Chloe Betts
doaj   +1 more source

Divinization, pilgrimage, and social inequality: experiences of women in the access to obstetric assistance

Revista Brasileira de Saúde Materno Infantil, 2021
Objectives: to understand the experiences of women from Brazilian northeastern semi-arid in accessing obstetric care. Methods: qualitative research conducted by the methodological framework of ethnonursing, carried out with 13 key informants in a public
Jameson Moreira Belém, Emanuelly Vieira Pereira, Rachel de Sá Barreto Luna Callou Cruz, Glauberto da Silva Quirino   +3 more
doaj   +2 more sources

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source