Results 41 to 50 of about 231,927 (270)

Structural Control of Stromal‐Immune Coupling by COL24A1 Underlies Pregnancy Maintenance

Advanced Science, EarlyView.
COL24A1 emerges as a collagen‐associated regulator of maternal‐fetal interface homeostasis. Its deficiency promotes a maladaptive TIMP1‐high stromal state, impaired ECM turnover, collagen accumulation, and stromal–immune dysregulation, contributing to pregnancy loss.
Teng Wu, Lingling Xie, Wenyi Liu, Hanjie Mo, Chengshu Xie, Jing Tang, Zhaorui Wang, Peixuan Lan, Jianping Zhang, Jie Gao, Qionglan Tang, Chunwei Cao, Hui Chen   +12 more
wiley   +1 more source

Improving obstetric hemorrhage morbidity by a checklist-based management protocol; a quality improvement initiative

, 2023
The implementation of a checklist-based management protocol for postpartum hemorrhage has shown a promising trend in improving maternal morbidity, screening, early diagnosis, and healthcare delivery for obstetric hemorrhage at our institution and has ...
Rachael B.SmithLaurie P.EricksonLaura T.MercerCatherine E.HermannMichael R.Foley
core   +1 more source

MAGI3 Acts as an Intestinal Epithelial Gatekeeper in Inflammation‐Associated Colorectal Cancer by Suppressing the STAT3‐CCL2 Axis and TAM‐Mediated Immunosuppression

Advanced Science, EarlyView.
Our study identifies MAGI3 as an intestinal epithelial gatekeeper that restrains inflammation‐associated colorectal tumorigenesis but is itself suppressed under highly inflammatory conditions. MAGI3 deficiency activates the STAT3‐CCL2 signaling, thereby promoting TAM‐mediated immunosuppression and inflammation‐associated colorectal tumor progression ...
Yumeng Yang, Zhigang Bai, Haibo Wang, Yu Guo, Yan Zhang, Meihan Hu, Shuaikang Fan, Ran Song, Tongmei Zhang, Mengqi Deng, Xiaomei Yang, Zhongtao Zhang, Junqi He   +12 more
wiley   +1 more source

Obstetric Hemorrhage, its role in maternal morbidity and mortality and the importance of its diagnosis, prevention and timely management

Mexican Journal of Medical Research ICSA, 2020
Background: In recent years, different international and national campaigns have been implemented to combat obstetric haemorrhage. Maternal mortality (MM) is one of the main concerns of public health and represents a good indicator to measure the quality
Ixchel Suyapa Reyes Espinoza
doaj   +1 more source

High Diagnosis Rate for Nonimmune Hydrops Fetalis With Prenatal Clinical Genome: Expanded Results From the Hydrops‐Yielding Diagnostic Results of Prenatal Sequencing (HYDROPS) Study

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Nonimmune hydrops fetalis (NIHF) is characterized by abnormal fluid accumulation in ≥ 2 fetal compartments and may be genetic. The incremental diagnostic yield of prenatal exome sequencing (ES) for NIHF following a negative standard workup was previously explored on 22 cases.
Stephanie M. Rice, Mona M. Makhamreh, Sascha Wodoslawsky, Mariella Toro, Elizabeth Critchlow, Brandy Firman, Ruby Liu, Babi Ramesh Nallamilli, Madhuri Hegde, Seth I. Berger, Huda B. Al‐Kouatly   +10 more
wiley   +1 more source

Local health workers’ perceptions of substandard care in the management of obstetric hemorrhage in rural Malawi

BMC Pregnancy and Childbirth, 2013
Background To identify factors contributing to the high incidence of facility-based obstetric hemorrhage in Thyolo District, Malawi, according to local health workers.
Beltman Jogchum Jan, van den Akker Thomas, Bwirire Dieudonné, Korevaar Anneke, Chidakwani Richard, van Lonkhuijzen Luc, van Roosmalen Jos   +6 more
doaj   +1 more source

Prevention of obstetric hemorrhages [PDF]

Ķazaķstannyṇ Klinikalyķ Medicinasy, 2017
Obstetric bleeding is an urgent problem in modern obstetric. It remains one of the main causes of maternal mortality. The article presents a literature review of world dates on the management of the third stage of labor, measures taken to prevent ...
Gauri Bapayeva, Saltanat Kulbayeva
doaj   +1 more source

Obstetric hemorrhage and adverse maternal outcomes: experience of a private teaching hospital in Southwestern Nigeria [PDF]

, 2019
Background: Obstetric hemorrhage (OH) has remained the leading cause of maternal mortality, despite concerted National efforts. This audit was conducted to determine its contribution to Adverse Maternal Outcomes and determinants of survival at a private ...
Olukemi, A.O., Inyang, F.A. Ani Franklin, Olumide, A., Osaigbovoh, J.I., Obafemi, J.S.   +4 more
core   +1 more source

Maternal Factors Modifying the Link Between Genetic Risk for Autism and Developmental Milestones

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Although common genetic liability—quantified through polygenic risk scores (PRS)—accounts for substantial variance in autism spectrum disorder (ASD) liability, how prenatal environmental exposures interact with genetic predisposition to shape developmental outcomes remains poorly understood. Using the data from Autism Genetic Resource Exchange
Liliana D'Alesio, Vishani Nimish Patel, McKenna Walsh, Erick Messias, Ping‐I Lin   +4 more
wiley   +1 more source

Over the edge: Empirical evidence for the cliff‐edge model of obstetric selection

The Anatomical Record, EarlyView.
Abstract The cliff‐edge model of obstetric selection maintains that larger neonates and smaller birth canals confer a positive selective advantage until labor becomes obstructed and vaginal delivery is no longer possible, eliciting an abrupt reduction in fitness.
Laura M. Watson, Pierre Frémondière, Kaspar Staub, Philipp Mitteroecker, Barbara Fischer, Martin Haeusler, Nicole M. Webb   +6 more
wiley   +1 more source