Results 281 to 290 of about 1,135,131 (382)

Prenatal Exome Sequencing Identifies Dual Maternal‐Fetal Diagnosis of HbF Mission Bay, a Novel HBG2 Variant Associated With Methemoglobinemia, Hypoxia and Hemolytic Anemia

Prenatal Diagnosis, EarlyView.
ABSTRACT Prenatal exome sequencing (ES) can establish rare genetic diagnoses in a fetus but may also lead to occult genetic diagnosis in a biological parent. We present a case of dual fetal and maternal diagnosis by prenatal ES, in a fetus with unexplained anemia and in a pregnant patient with sickle cell disease (SCD) and recurrent unexplained hypoxia.
Matthew A. Shear, Billie Lianoglou, Ugur Hodoglugil, W. Patrick Devine, Ashutosh Lal, Juan Gonzalez, Teresa N. Sparks   +6 more
wiley   +1 more source

Low-dose oral misoprostol vs. oxytocin in premature rupture of membranes at ≥ 36 weeks: a comparison of labor induction outcomes and postpartum hemorrhage risk. [PDF]

BMC Pregnancy Childbirth
Yang Y, Yu Z, Shi H, Wang Y, Zhao Y.
europepmc   +1 more source

Whole Genome Sequencing in Prenatal Diagnostics: The Danish Approach to Guideline Formation and Implementation Within Public Healthcare

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective To describe the implementation of whole genome sequencing (WGS) in prenatal diagnostics and outline the national guideline system facilitating this. Methods Clinical guidelines for WGS in prenatal diagnostics were developed and implemented by the Danish Fetal Medicine Society.
Ida Vogel, Lotte Andreasen, Marie Balslev‐Harder, Naja Becher, Anja Ernst, Kasper Gadsbøll, Tina Duelund Hjortshøj, Marie Skov Hvidbjerg, Martin Larsen, Stina Lou, Ida Charlotte Bay Lund, Lars Henning Pedersen, Laura Kirstine Sønderberg Roos, Lene Sperling, Lone Sunde, Pernille Mathiesen Tørring, Cathrine Vedel, Olav Bjørn Petersen   +17 more
wiley   +1 more source

Eutocic delivery vs. cesarean section: a multicenter retrospective study of factors influencing cesarean rates in Robson groups 1, 2a, 3, and 4a across birth centers. [PDF]

Front Med (Lausanne)
Musicco A, Sfregola G, Dicuonzo V, Bolgeo T, Milone V, Dicuonzo G, Iovino P, Ruta F.   +7 more
europepmc   +1 more source

Yield of Whole Genome Sequencing for Pathogenic Single Nucleotide Variants in Congenital Heart Disease: A Systematic Review and Meta‐Analysis

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective This systematic review and meta‐analysis aimed to assess the diagnostic yield of pathogenic or likely pathogenic (P/LP) single nucleotide variants (SNVs) using whole genome sequencing (WGS) in congenital heart disease (CHD). Methods A systematic search of three databases (2000–2024) was conducted, and two reviewers independently ...
Hiba J. Mustafa, Parisa Najjariasl, Faezeh Aghajani, Enaja V. Sambatur, Andrew Rodenbarger, Stephanie Guseh, Amy E. Roberts, Alireza A. Shamshirsaz   +7 more
wiley   +1 more source

Predictive factors for vaginal delivery in pregnant women with previous cesarean section: a case-control study. [PDF]

Rev Bras Ginecol Obstet
Reis GS, Lopes LCP, Vendramini ECG, Damaso ÊL, Borges VTM.   +4 more
europepmc   +1 more source

The Expanding Role of Gene Sequencing in Shaping Fetal Therapies: Clinical and Ethical Considerations

Prenatal Diagnosis, EarlyView.
ABSTRACT In utero interventions are transformative in addressing genetic and anatomic conditions during fetal development. Next generation sequencing enables early genetic testing, playing a pivotal role in prenatal decision‐making by supporting risk stratification, precise and timely diagnosis, which directly informs eligibility for fetal surgical and
Matthew A. Shear, Beltran Borges, Billie R. Lianoglou, Tony Lum, Emma Canepa, Jennifer L. Cohen, Julia E. H. Brown, Akos Herzeg   +7 more
wiley   +1 more source

Maternal outcomes among women with intellectual disabilities in comparison with the general population (IDcare). [PDF]

AJOG Glob Rep
Axmon A, Liu C, Grotta A, Edvardsson K, Sandberg M.   +4 more
europepmc   +1 more source

Insights Into Congenital Lymphatic Anomalies Underlying Fetal Effusions

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective We describe a series of pregnancies with autosomal dominant lymphedema and generalized lymphatic dysplasia in the fetus diagnosed with prenatal exome or genome sequencing. We focus on specific syndromes, fetal features, and parental symptoms to deepen our understanding of congenital lymphatic anomalies.
Sara G. Vargo, Daniella Rogerson, Patrick Devine, Jessica Van Ziffle, Teresa N. Sparks   +4 more
wiley   +1 more source

Development and validation of a nomogram for predicting intrapartum fever in parturients with epidural analgesia. [PDF]

Front Med (Lausanne)
Niu DG, Wang L, Wei RY, Li J, Zhu YN, Zhang H, Yao L.   +6 more
europepmc   +1 more source