Results 51 to 60 of about 49,487 (311)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Obstetric Nurses’ Perceived Barriers to Immediate Skin to Skin Contact after Cesarean Birth [PDF]

, 2018
Despite the strong evidence supporting immediate skin to skin contact (SSC) after birth, research suggests that patients who undergo cesarean births do not have the same opportunities for SSC as patients who undergo vaginal births.
Balatero, Joelene Sarmiento
core   +1 more source

The effect of surveillance and appreciative inquiry on puerperal infections : a longitudinal cohort study in India [PDF]

, 2014
Peer reviewedPublisher ...
CA Carter, D Pittet, D Pittet, D Pittet, Dileep Mavalankar, DM Yealy, Harin A. Karunajeewa, J Hussein, J Hussein, Jacqueline Bell, Julia Hussein, K. V. Ramani, Kalpesh Patel, KS Khan, Leighton Walker, Lovney Kanguru, M Ashraf, MC Ruhe, N Tharpe, P Rajaram, PN Anandalakshmy, Purvi Patel, R Kumar, R Mehta, Rajesh Mehta, RW Haley, S Singh, SP Stone, TG Rana   +28 more
core   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Thoracic interfascial nerve block for breast surgery in a pregnant woman: a case report [PDF]

Korean Journal of Anesthesiology, 2017
Regional anesthesia for non-obstetric surgery in parturients is a method to decrease patient and fetal risk during general anesthesia. Thoracic interfascial nerve block can be used as an analgesic technique for surgical procedures of the thorax. The Pecs
Boohwi Hong, Seok-Hwa Yoon, Ann Misun Youn, Bum June Kim, Seunghyun Song, Yeomyung Yoon   +5 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Essential surgery at the district hospital: a retrospective descriptive analysis in three African countries.

PLoS Medicine, 2010
BackgroundSurgical conditions contribute significantly to the disease burden in sub-Saharan Africa. Yet there is an apparent neglect of surgical care as a public health intervention to counter this burden.
Moses Galukande, Johan von Schreeb, Andreas Wladis, Naboth Mbembati, Helder de Miranda, Margaret E Kruk, Sam Luboga, Alphonsus Matovu, Colin McCord, S Khady Ndao-Brumblay, Doruk Ozgediz, Peter C Rockers, Ana Romàn Quiñones, Fernando Vaz, Haile T Debas, Sarah B Macfarlane   +15 more
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Non-adherence to surgical antibiotic prophylaxis guidelines: findings from a mixed-methods study in a developing country

Antimicrobial Resistance and Infection Control
Objectives The effectiveness of surgical antibiotic prophylaxis in reducing the risk of post-operative infectious morbidity, depends on its appropriate use.
Noha Ali, Ranim Hamouda, Rana Tarek, Menna Abdelhamid, Abdullah Lashin, Rania Hassan, Rania Gamal, Mourad Elfaham, Aya Attia, Ahmed Abdelaleem, Noha Sakna, Amgad Gamal, Sally Aboelenin, Rahma AbdelHafez, Sara Abdelkader, Ashraf Nabhan   +15 more
doaj   +1 more source

The impact of training non-physician clinicians in Malawi on maternal and perinatal mortality : a cluster randomised controlled evaluation of the enhancing training and appropriate technologies for mothers and babies in Africa (ETATMBA) project [PDF]

, 2012
Background: Maternal mortality in much of sub-Saharan Africa is very high whereas there has been a steady decline in over the past 60 years in Europe. Perinatal mortality is 12 times higher than maternal mortality accounting for about 7 million neonatal
A Wilson, C McCord, C Pereira, C Pereira, C Pope, Chisale Mhango, D Ellard, David Davies, David Ellard, Doug Simkiss, E McAuliffe, F Mullan, Francis Kamwendo, G Chilopora, J Bryce, J Ritchie, Joseph Paul O’Hare, K Hill, Ministry of Health, National Statistical Office (NSO), and ICF Macro, Ngianga-bakwin Kandala, S Bergstrom, S Bradley, S Niermeyer, Siobhan Quenby, W Graham, W Graham, World Health Organization, UNICEF, UNFPA, and The World Bank   +27 more
core   +2 more sources