Results 101 to 110 of about 10,598 (239)

Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis

Prenatal Diagnosis, EarlyView.
ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell, Samantha Stover, Nora Gibson, Timothy Olson, James Connelly, Matthew Grace, Jennifer Andrews   +6 more
wiley   +1 more source

Sickle Cell Disease: Historical Overview and Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide, yet the limited treatment options currently available do not always adequately control the disease and carry significant side effects. At present, the only curative treatment is hematopoietic stem cell (HSC) transplantation, a procedure that carries considerable challenges and numerous ...
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

The Continued Significance of Obstetric Violence: A Response to Chervenak, McLeod-Sordjan, Pollet et al

Health Equity
This guest editorial offers a critical response to Chervenak, McLeod-Sordjan, Pollet et al.’s clinical opinion dismissing obstetric violence as both emotionally charged and damaging to provider–patient relationships.
Dána-Ain Davis, Monica J. Casper, Evelynn Hammonds, Wendy Post   +3 more
doaj   +1 more source

Development of a High‐Throughput Microarray Platform for Rapid, Low‐Cost Expanded Carrier Screening

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective To develop a customized expanded carrier screening (ECS) solution for 8271 variants of 265 genes. Based on a microarray platform, this solution demonstrates comparable accuracy to next‐generation sequencing (NGS) platform; however, it has a lower cost, a faster speed, and a simplified data—analysis process.
Jiazhen Chang, Na Hao, Xiya Zhou, Yan Lü, Mengmeng Li, Kaili Yin, Xueting Yang, Hanzhe Zhang, Yukun Ma, Yanqin You, Qingwei Qi, Yulin Jiang   +11 more
wiley   +1 more source

Non‐Invasive Prenatal Diagnosis of Haemoglobinopathies: From Concept to Clinical Reality

Prenatal Diagnosis, EarlyView.
ABSTRACT Haemoglobinopathies are the most prevalent monogenic disorders worldwide, contributing significantly to childhood morbidity and mortality. Preventive strategies, including carrier screening and prenatal diagnosis, have successfully reduced disease incidence in regions with established programmes.
Irene Leonidou, Leila Sallie, Morgan Jean Bell‐Ricketts, Alexandros Abdel Massih, Lisa Joy Kaiser, Ashley Hoi Kiu Wong, María Teresa Martín Monreal, Panicos Shangaris   +7 more
wiley   +1 more source

Dual‐Component Spidroin‐Based Hydrogels: A Mechanically Tunable Platform for 2D and 3D Cell Culture

Small, EarlyView.
A dual‐component recombinant spider silk hydrogel platform was developed by combining NT2RepCT with a bioactive vitronectin‐functionalized spidroin domain. The hydrogels self‐assemble under physiological conditions, exhibit tunable mechanical properties, and support 2D and 3D cell culture, providing a versatile platform for mechanobiological studies ...
Sanna Korpela, Urmimala Chatterjee, Gabriele Greco, Benjamin Schmuck, Rakesh Kumar, Olga Shilkova, Cecilia Götherström, Anna Rising, Teemu O. Ihalainen   +8 more
wiley   +1 more source

From Effectiveness to Long‐Term Impact. Sustainability of a Frugal Managed Surgical Consultation Network in Low‐Income Settings: Evidence From Malawi

World Journal of Surgery, EarlyView.
Digital technology holds transformative potential to address barriers to safe and timely surgical expertise and surgery in low‐resource settings, where shortages of specialists, fragmented referral systems, and limited infrastructure remain significant challenges. In 2018, Malawi launched a managed surgical clinical network (MCN) in the Southern region,
Jakub Gajewski, Kaja Czwojda, Chiara Pittalis, Ruairi Brugha, Jonathan Waluza, Patrick Noah, Eric Borgstein   +6 more
wiley   +1 more source

The Timely Rise of a Teenage Reformer: Youth Revolt, Feminism and the Struggle for a ‘New Sexual Morality’ at the Dawn of the Spanish Second Republic

Gender &History, EarlyView.
ABSTRACT The contributions of propagandist and writer Hildegart (1914–1933) to Spanish cultural life are overshadowed by accounts of her unusual upbringing and violent death. This article examines the conditions that enabled the teenager to become a prominent voice for feminism and sexual reform on the eve of Spain's Second Republic (1931–1939).
Micaela Pattison
wiley   +1 more source

Gender and Obstetric Violence in Britain, ca. 1750–1830

Gender &History, EarlyView.
ABSTRACT Obstetric violence is a form of gendered violence experienced by pregnant and birthing people, particularly women, during medical care provided in the hospital, clinic or home. Recent scholarship has explored how obstetric violence and obstetric racism manifested historically, from post‐war Canada to colonial and postcolonial Mexico.
Paige Donaghy
wiley   +1 more source

Political Recruitment and Pregnancy Resources: Anti‐Abortion Feminists Come to Campus, United States, 1990s

Gender &History, EarlyView.
ABSTRACT This article examines Feminists for Life's (FFL) rhetoric and activism on US college campuses in the 1990s as a case study into the complexities of organizing against abortion in a historical context whereby few supports existed for young pregnant women.
Isobel Bloom
wiley   +1 more source