Results 111 to 120 of about 189,934 (383)

Mortalin and PINK1/Parkin‐Mediated Mitophagy Represent Ovarian Cancer‐Selective Targets for Drug Development

open access: yesAdvanced Science, EarlyView.
Ovarian cancer patients with high levels of mortalin protein in their tumors have worse survival. The investigational drug SHetA2 interferes with mortalin's support of mitochondria. The resulting mitochondrial damage causes a process called mitophagy that contributes to how SHetA2 kills cancer cells. Noncancerous cells repair their mitochondria through
Vishal Chandra   +9 more
wiley   +1 more source

Characteristics Symptoms of Imminent Eclampsia: A case Referent Study from a Tertiary Hospital in Tanzania [PDF]

open access: yes, 2012
\ud \ud Maternal mortality in developing coun- tries is unacceptably high with eclampsia being con- sistently among the top causes. As yet, primary pre- vention of this complication is not possible since causes of pre-eclampsia are largely unknown and ...
France, John, Muganyizi, Projestine S.
core  

EETs Reduction Contributes to Granulosa Cell Senescence and Endometriosis‐Associated Infertility via the PI3K/AKT/mTOR Signaling Pathway

open access: yesAdvanced Science, EarlyView.
1) 14, 15‐EET levels were decreased in ovarian granulosa cells, follicular fluid, peritoneal fluid from endometriosis patients. 2) EETs reduction in endometriosis follicular fluid aggravated granulosa cell senescence. 3) ROS reduced 14, 15‐EET levels by upregulating EPHX2 through a mechanism involving histone methylation modification.
Xiang Lin   +11 more
wiley   +1 more source

Diabetic pregnancy outcome in Malta the outcome of non-gestational diabetic pregnancies in the Maltese Islands [PDF]

open access: yes, 2004
Diabetes in pregnancy is generally associated with a higher morbidity and mortality for both the mother and child. Objective: The study aims to assess the outcome indicators of diabetic pregnant women and compare these to the remaining obstetric ...
Azzopardi, Joseph   +4 more
core  

eIF4E Enriched Extracellular Vesicles Induce Immunosuppressive Macrophages through HMGCR‐Mediated Metabolic Rewiring

open access: yesAdvanced Science, EarlyView.
Here, it is revealed that ovarian cancer cells release extracellular vesicles enriched with eIF4E, which alters protein production in macrophages. This leads to increased expression of 3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme A reductase (HMGCR), boosting cholesterol synthesis and activating an immunosuppressive pathway through X‐box binding protein 1 and ...
Sonam Mittal   +15 more
wiley   +1 more source

Atosiban in the management of preterm labour [PDF]

open access: yes, 2011
Peer reviewedPublisher ...
Bhattacharya, Sohinee   +3 more
core   +3 more sources

‘Standardized patients’ in teaching the communication skill of history-taking to four-year foreign medical undergraduates in the department of obstetrics and gynaecology

open access: yesBMC Medical Education, 2019
Background Many foreign students have difficulty taking histories from Chinese patients, especially in clinical context of the Department of Obstetrics and Gynaecology.
Jing Zhang   +4 more
doaj   +1 more source

A common medical schools curriculum in obstetrics and gynaecology

open access: yesAustralian and New Zealand journal of obstetrics and gynaecology, 2018
Despite increasing recognition of the importance of the vertical alignment of learning in medicine, there has been little attempt in practice to link undergraduate to postgraduate training with the universities and postgraduate training providers working
I. Symonds
semanticscholar   +1 more source

m6A Reader hnRNPA2B1 Modulates Late Pachytene Progression in Male Meiosis Through Post‐Transcriptional Control

open access: yesAdvanced Science, EarlyView.
As an m6A reader, hnRNPA2B1 predominantly regulates specific transcripts (e.g., Ep400, Rrs1) that are essential for chromosome organization and remodeling in an m6A‐dependent manner. Furthermore, it is demonstrated to interact with factors involved in mRNA processing and translation. This dual functionality is pivotal for ensuring the proper occurrence
Lisha Yin   +11 more
wiley   +1 more source

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