Results 121 to 130 of about 189,934 (383)

H3K27ac Is Essential for Human Naive Pluripotency Modulated by m6A‐Driven EP300 Expression

open access: yesAdvanced Science, EarlyView.
An et al. reveal H3K27ac elevation is essential for establishing and maintaining human naive pluripotency; its inhibition disrupts this state while enhancement promotes it. METTL3‐mediated m6A modification indirectly controls H3K27ac by suppressing EP300 expression. Reduced EP300 lowers H3K27ac, impeding naive pluripotency.
Chenrui An   +13 more
wiley   +1 more source

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang   +15 more
wiley   +1 more source

Reporting and Analysis of Trial-Based Cost-Effectiveness Evaluations in Obstetrics and Gynaecology

open access: yesPharmacoEconomics (Auckland), 2017
Background and ObjectivesThe aim was to systematically review whether the reporting and analysis of trial-based cost-effectiveness evaluations in the field of obstetrics and gynaecology comply with guidelines and recommendations, and whether this has ...
M. El Alili   +4 more
semanticscholar   +1 more source

Hypoxia‐Induced PRMT1 Lactylation Drives Vimentin Arginine Asymmetric Dimethylation in Tumor Metastasis

open access: yesAdvanced Science, EarlyView.
Hypoxia triggers lactylation of PRMT1 at K134/K145, enhancing its methyltransferase activity to asymmetrically dimethylate vimentin R64. This post‐translational cascade promotes vimentin filament assembly, cytoskeletal remodeling, and tumor metastasis, with PRMT1 inhibition (MS023) reducing metastatic colonization.
Jia Zhou   +16 more
wiley   +1 more source

Assessing the see-and-treat approach for the management of high-grade squamous intraepithelial cervical lesions [PDF]

open access: yes, 2019
Objectives: To assess local histological outcomes in patients with HSIL cytology results on cervical smears, in both the see-and-treat and three-step approach.
Brincat, Mark R.   +4 more
core  

Indirect assessment of hemorrhoid incidence using invasive treatment data in Japan: A 5‐year study based on nationwide health insurance claims

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
This study aimed to clarify the epidemiology of hemorrhoids by leveraging a comprehensive nationwide healthcare claims database in Japan. By analyzing invasive treatments for hemorrhoids over a 5‐year period (2018–2022), we identified key demographic patterns, including distinct bimodal peaks in incidence among males and females, and highlighted ...
Masamitsu Kido   +8 more
wiley   +1 more source

Factors influencing medical students' decision to pursue a career in obstetrics and gynaecology. [PDF]

open access: yesPLoS One, 2023
Ní hÉalaithe C   +7 more
europepmc   +1 more source

Home - About - Disclaimer - Privacy