Results 201 to 210 of about 175,790 (296)

A novel PTEN variant causing hemimegalencephaly and focal nodular heterotopias in the developing human brain

open access: yesEpilepsia, EarlyView.
Abstract Brain development and subsequent brain function are highly sensitive to genetic mutations, which can result in severe neurodevelopmental malformations. Alterations in PTEN signaling cause a spectrum of developmental malformations and neurological diseases including epilepsy.
Franziska Fazekas   +16 more
wiley   +1 more source

Prenatal betamethasone–postnatal N‐methyl‐D‐aspartic acid model of spasms: Update on mechanisms and treatments

open access: yesEpilepsia Open, EarlyView.
Abstract Infantile epilepsy spasms syndrome (IESS), formerly known as infantile spasms or West Syndrome, is a severe epilepsy syndrome affecting about 3 in 10,000 newborns in the United States. Characterized by clusters of epileptic spasms, interictal hypsarrhythmia, and developmental delays, IESS has diverse causes, including structural‐metabolic ...
Kayla Vieira   +5 more
wiley   +1 more source

Good teaching practices for organizing and conducting clinical classes in obstetrics and gynaecology for medical undergraduate students at the English Division. [PDF]

open access: yesBMC Med Educ
Kacperczyk-Bartnik J   +8 more
europepmc   +1 more source

Age‐Related Trends in Eating‐Pathology Symptoms Among Sexual Minority Adults

open access: yesEuropean Eating Disorders Review, EarlyView.
ABSTRACT Objective To examine how eating‐disorder symptoms vary by chronological age and sexual orientation in sexual minority adults. Method Cross‐sectional data came from 2062 cisgender sexual minority participants (925 gay men, 573 lesbian women, 116 bi+ men, 448 bi+ women; age = 47.8 years, range = 18–96).
Jason M. Nagata   +11 more
wiley   +1 more source

Validation of the World Health Organization Disability Assessment Schedule‐II for Measuring Women With a History of Potentially Life‐Threatening Maternal Conditions at Six Months Postpartum in Tigray, Northern Ethiopia

open access: yesHealth Care Science, EarlyView.
The World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) of the Tigrigna version has strong internal consistency (Cronbach's α coefficients = 0.98). The convergent validity between the 36‐item and 12‐item WHODAS 2.0 indicated a strong correlation (r = 0.909–0.981) within similar domains.
Fitiwi Tinsae Baykemagn   +3 more
wiley   +1 more source

Detecting TP53 mutations in paired liquid and tissue biopsies from patients with high‐grade serous ovarian carcinoma

open access: yesInternational Journal of Cancer, EarlyView.
What's New? High‐grade serous ovarian carcinoma is often diagnosed at advanced stages due to non‐specific symptoms and the lack of reliable screening methods. This proof‐of‐concept study introduces a novel TP53 mutation panel using unique molecular identifier‐based next‐generation sequencing for sensitive detection of high‐grade serous ovarian ...
Amanda Olsson Widjaja   +11 more
wiley   +1 more source

Challenges in the future of cancer screening

open access: yesInternational Journal of Cancer, EarlyView.
Abstract The purpose of cancer screening is to reduce mortality, and ideally incidence, from the cancer screened for. Until recently, cancer screening has been offered to all persons in pre‐defined sex‐ and age‐groups. The exception is lung screening which is targeted to high‐risk individuals.
Elsebeth Lynge   +29 more
wiley   +1 more source

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