Results 121 to 130 of about 670,125 (262)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Climate Obstruction in the European Union : Business Coalitions and the Technocracy of Delay
The European Union has gained increasing influence in setting climate policy. Its power to determine the orientation of the integrated body and in negotiation and decision-making gives the European Union a privileged role in the climate policies of ...
Plehwe, Dieter, +3 more
core +1 more source
Intestinal Obstruction Due To Phytobezoars Report of 3 Cases
, 2013 Bezoar is a stone of swallowed foreign material in the gastrointestinal tract and causes mechanic obstruction that requires surgical treatment. In this paper we are presenting 3 cases who underwent surgery.
Șiyar Ersöz +5 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Probing of congenital nasolacrimal duct obstruction with dacryoendoscope
, 2014 Kumiko Kato, Koichi Matsunaga, Yuko Takashima, Mineo KondoDepartment of Ophthalmology Mie University School of Medicine, Tsu, JapanBackground: A congenital nasolacrimal duct obstruction (CNLDO) is a relatively common disease in infants.
Kato K +3 more
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Climate Obstruction in Sweden : The Green Welfare State - Both Progressive and Obstructionist
Applying the concepts of primary, secondary, and tertiary climate obstruction, this chapter explores the concept of Swedish ‘middle way’ environmental politics as a type of secondary obstruction.
Vowles, Kjell, +5 more
core +1 more source
Biomedicine HubIntroduction: Airflow obstruction (AO) is evidenced by reduced forced expiratory volume in 1 s/forced vital capacity (FEV1/FVC) with the threshold for diagnosis often being set at <0.7.
Lora Wahab +3 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Rare small bowel obstruction due to phytobezoar – Case presentation [PDF]
, 2017 Phytobezoar is a rare cause of small bowel obstruction. This pathology represents 0.4%-4% of all mechanical bowel obstructions. Symptoms are similar to other small bowel obstructions.
Alexandru C. Carâp +9 more
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