Results 131 to 140 of about 1,085,850 (360)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Wind Instrument Training and Sound-Based Interventions for Sleep Quality and Obstructive Sleep Apnoea: A Narrative Synthesis

Noise and Health
Background: Tolerability issues with continuous positive airway pressure (CPAP) therapy for obstructive sleep apnoea (OSA) have spurred interest in nonpharmacological alternatives like sound-based interventions (wind instrument training, singing and ...
Yi Ding, KaiLi Jiang
doaj   +1 more source

LIFE EXPECTANCY AND EXPECTED YEARS OF LIFE LOST IN PATIENTS WITH SEVERE CHRONIC OBSTRUCTIVE PULMONARY DISEASE [PDF]

, 2018

openalex   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Oral Health-Related Functional Factors Associated with Different Levels of Obstructive Sleep Apnea Risk in Korean Adults: Analysis of a National Survey

치위생과학회지
Background: This study aimed to investigate the association between oral health-related functional and symptomatic factors and risk of obstructive sleep apnea (OSA) among Korean adults aged ≥40 years, with a focus on identifying oral health indicators ...
Hee-Kyeong Bak, Na-Young Lee, Han-Na Kim
doaj   +1 more source

Decision letter for "A homozygous loss‐of‐function mutation in FBXO43 causes human non‐obstructive azoospermia"

, 2021

openalex   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Obstructive Airway Disease: Rational, Evidence-Based Bronchodilator Therapy [PDF]

, 2017
Michael T. Newhouse, Israel Amirav
openalex   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

A focus on paediatric obstructive sleep apnoea [PDF]

, 2018
Edward Fisher, Robin Youngs, Musheer Hussain, Jonathan Fishman   +3 more
openalex   +1 more source