Results 331 to 340 of about 499,895 (395)

Stabilisation of PRCP by deubiquitinase‐targeting chimera (DUBTAC) to replenish autophagy for ameliorating pathological cardiac hypertrophy

British Journal of Pharmacology, EarlyView.
Background and Purpose Autophagy is essential for cellular homeostasis, and its impairment contributes to cardiac hypertrophy. Modulating autophagy has shown potential in treating pathological hypertrophy. Prolylcarboxypeptidase (PRCP), a lysosomal enzyme that hydrolyzes angiotensin II to Ang1‐7, has an unclear role in cardiac autophagy and hypertrophy.
Fangchao Zhou, Jun Xia, Yingjuan Liu, Wenqi He, Hongyuan Zhang, Bernard D. Keavney, Min Zi, Binh Y. Nguyen, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Susanne S. Hille, Elizabeth J. Cartwright, Oliver J. Müller, Honglin Xu, Sam Butterworth, Xin Wang   +16 more
wiley   +1 more source

Elevated COMMD1 Contributes to Cardiomyocyte Copper Efflux in Chronic Myocardial Ischemia: Insights From Rhesus Monkey

Cell Proliferation, EarlyView.
Elevated COMMD1 contributes to copper efflux in cardiomyocytes during chronic ischaemia in rhesus monkey hearts, regulated by XIAP through post‐translational modification. Our findings suggest a positive feedback loop among XIAP, COMMD1 and copper efflux, contributing to ischaemic cardiomyocyte loss.
Chen Li, Da Li, Xia Cheng, Xiaoli Yuan, Ning Du, Xin Liao, Xiaorong Feng, Jie Yao, Chenglong Li, Chengxia Xie, Mu Yang   +10 more
wiley   +1 more source

A preoperative planning procedure of septal myectomy for hypertrophic obstructive cardiomyopathy using image-based computational fluid dynamics simulations and shape optimization. [PDF]

Sci Rep
Ding Z, Liu Q, Luo H, Yang M, Zhang Y, Wang S, Luo Y, Chen S.   +7 more
europepmc   +1 more source

Role of Histone Deacetylase and Inhibitors in Cardiovascular Diseases

Cell Proliferation, EarlyView.
HDACs play an important role in the occurrence and development of cardiovascular diseases, such as myocardial hypertrophy, hypertension, and atherosclerosis. HDAC inhibitors have broad prospects for the treatment of CVD, and different HDAC subtypes can act through different mechanisms.
Li‐Ying Zhang, Yue‐Yue Wang, Ri Wen, Tie‐Ning Zhang, Ni Yang   +4 more
wiley   +1 more source

Recurrent atrial flutter after radiofrequency ablation for atrial fibrillation in a patient with hypertrophic obstructive cardiomyopathy undergoing repetitive transcoronary ablation of septal hypertrophy. [PDF]

BMC Cardiovasc Disord
Cheng L, Wang N, Dai L, Ding H, Geng Z, Son Y.   +5 more
europepmc   +1 more source

Tirzepatide and cardiometabolic parameters in obesity: Summary of current evidence

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Globally, cardiovascular diseases (CVDs) account for around one‐third of all deaths. Clinical trial evidence suggests that treatment of people with obesity or type 2 diabetes (T2D) and CVD with glucagon‐like peptide‐1 (GLP‐1) receptor agonists reduces the risk of major adverse cardiovascular events, heart failure outcomes and all‐cause ...
Naveed Sattar, Luis‐Emilio García‐Pérez, Angel Rodríguez, Richa Kapoor, Adam Stefanski, Emily R. Hankosky   +5 more
wiley   +1 more source

The UMPIRE study: A first‐in‐human multicenter trial of bilateral subscalp monitoring for epileptic seizure detection

Epilepsia, EarlyView.
Abstract Objective Patient self‐report is known to be an inaccurate reflection of true seizure frequency in persons with epilepsy. The current study aimed to assess the safety and performance of the Minder system, a bilateral subscalp electroencephalographic (EEG) acquisition system for continuous long‐term EEG recording.
Amy J. Halliday, Lisa Gillinder, Alan Lai, Udaya Seneviratne, Holly Fontenot, Tracy Cameron, Karen McLean, Andrew Niemiec, Ramya Raghupathi, Taneeta M. Ganguly, Colin Ellis, Erin C. Conrad, Robert Briggs, Kristian Bulluss, Patrick Kwan, Piero Perucca, Terence J. O'Brien, Aileen McGonigal, Matthew Gutman, Jason Papacostas, Michael W. K. Fong, Andrew Lee, Douglas E. Crompton, Joshua Laing, Manori Wijayath, Andrew P. Morokoff, Michael Murphy, Wendyl J. D'Souza, Mark J. Cook   +28 more
wiley   +1 more source

Early left atrial reverse remodelling in patients with hypertrophic obstructive cardiomyopathy receiving transapical beating-heart septal myectomy. [PDF]

Interdiscip Cardiovasc Thorac Surg
Lu S, Zhang J, Zhu Y, Zhou W, Cheng X, Wang H, Chen Y, Wei X, Liu Y.   +8 more
europepmc   +1 more source

Tissue-level evidence of fibroblast activation protein inhibitor imaging in hypertrophic obstructive cardiomyopathy: a case series. [PDF]

Eur Heart J Case Rep
Li L, Gao J, Liu X, Chen BX, Su P, Xie B.   +5 more
europepmc   +1 more source