Results 151 to 160 of about 67,015 (304)

CYP2C19 genotype testing for clopidogrel: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, Volume 92, Issue 2, Page 329-347, February 2026.
Clopidogrel, an antiplatelet agent, is currently licensed in the United Kingdom for the prevention and treatment of atherothrombotic events in cerebrovascular disease, coronary artery disease and peripheral arterial disease. Clopidogrel requires metabolic activation by the cytochrome P450 enzyme CYP2C19 to be effective.
Cinzia Dello Russo, Iain Frater, Rebecca Kuruvilla, Stefanie Lip, Hannah O'Neill, Kerry Burke, Vicky Chaplin, Alexander S. F. Doney, Salim Elyas, Nicholas Greaves, Sophie Harding, David Hargroves, Judith Hayward, Dyfrig A. Hughes, Tom A. T. Hughes, Sree Kondapally, Patrick Mok, Aaron Peace, Imran Rafi, Simon Ray, Vicky Stinton, Luigi Venetucci, Munir Pirmohamed   +22 more
wiley   +1 more source

Rationale and Design of the Cooperative Program for ImpLementation of Optimal Therapy in Heart Failure

Clinical Cardiology, Volume 49, Issue 2, February 2026.
The COPILOT‐HF trial is a pragmatic, randomized study designed to determine if a remote, pharmacist‐led navigator‐driven intervention with patient and provider education is more effective than patient and provider education alone at improving the implementation of guideline‐directed medical therapy for patients across the full spectrum of heart failure.
Alexander J. Blood, Ozan Unlu, John W. Ostrominski, Shahzad Hassan, Hunter Nichols, Samantha Subramaniam, Daniel Gabovitch, Jacqueline Chasse, Marian McPartlin, Christian Figueroa, Emma Collins, Megan Twining, Matthew Varugheese, Kavishwar Wagholikar, Christopher P. Cannon, Akshay S. Desai, Benjamin M. Scirica   +16 more
wiley   +1 more source

BAS/BSCR45 The mitochondrial permeability transition pore as a target for cardioprotection in ventricular cardiomyocytes harvested from patients with obstructive hypertrophic cardiomyopathy [PDF]

, 2010
Paul Rees, Sean M. Davidson, Siân E. Harding, Perry M Elliot, Derek M. Yellon, Derek J. Hausenloy   +5 more
openalex   +1 more source

Heyde Syndrome: A Literature Review

Health Science Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background and Aims Heyde syndrome, a triad of anemia from gastrointestinal (GI) bleeding, aortic valve stenosis, and acquired von Willebrand syndrome, primarily affects individuals over 65. Management requires a multidisciplinary approach, including medical therapy, endoscopic intervention, and valve replacement.
Yashika Gupta, Abdul Rehman Shahid Khan, Viraj Shetty, Yeshwini Murali Krishna, Ayisha Maqsood, Muhammad Husnain Ahmad, Masab Ali, Betsy Samuel, Ali Gohar, Abdul Waheed, Muhammad Bilal Afzal, Rehan Naseer Ahmad, Saqib Maqsood   +12 more
wiley   +1 more source

Current Trends in Duchenne Muscular Dystrophy Research and Therapy: 3D Cardiac Modelling

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Duchenne muscular dystrophy (DMD), caused by dystrophin deficiency, presents a multifaceted challenge that affects both skeletal muscle function and cardiomyocyte homeostasis, causing progressive degeneration and life‐threatening cardiac complications by adolescence.
Marta Przymuszała, Marta Białobrzeska, Józef Dulak, Urszula Florczyk‐Soluch   +3 more
wiley   +1 more source

Novel Echocardiographic Index for Risk Stratification of Ventricular Arrhythmias and Mortality Based on Right Ventricular Function

Journal of Arrhythmia, Volume 42, Issue 1, February 2026.
Patients undergoing ICD implantation with both preprocedural echocardiography and cardiac magnetic resonance (CMR) were retrospectively analyzed to assess right ventricular (RV) function. Echocardiographic RV fractional area change (RVFAC) and the contraction pressure index (CPI), as well as CMR‐derived RV ejection fraction (RVEF), predicted ...
Toshinori Chiba, Takatsugu Kajiyama, Yusuke Kondo, Hiroyuki Takaoka, Noriko Suzuki‐Eguchi, Masahiro Nakano, Miyo Nakano, Satoko Ryuzaki, Yukiko Takanashi, Yuya Komai, Yusei Nishikawa, Yoshio Kobayashi   +11 more
wiley   +1 more source

Phase 2 Study of Aficamten in Patients With Obstructive Hypertrophic Cardiomyopathy.

Journal of the American College of Cardiology, 2023
M. Maron, Ahmad Masri, L. Choudhury, I. Olivotto, S. Saberi, Andrew Wang, P. García-Pavía, N. Lakdawala, Sherif F. Nagueh, F. Rader, A. Tower-Rader, A. Turer, C. Coats, M. Fifer, A. Owens, S. Solomon, H. Watkins, R. Barriales-Villa, C. Kramer, T. Wong, S. Paige, S. Heitner, S. Kupfer, F. Malik, L. Meng, A. Wohltman, T. Abraham   +26 more
semanticscholar   +1 more source

Predictors of Atrial High‐Rate Episodes and Inappropriate Device Therapy in Implantable Cardioverter Defibrillators

Pacing and Clinical Electrophysiology, Volume 49, Issue 2, Page 71-81, February 2026.
ABSTRACT Background Implantable cardioverter defibrillator (ICD) therapy can prevent sudden cardiac death, but poses a risk of inappropriate device therapy (IDT), which is linked to worse outcomes and reduced quality of life. On the other hand, ICDs can function as an early warning system for atrial arrhythmias.
Marthe J. Huntelaar, Luuk H. G. A. Hopman, Anne‐Lotte C. J. van der Lingen, Mischa T. Rijnierse, Michiel J. B. Kemme, Cornelis P. Allaart, Vokko P. van Halm   +6 more
wiley   +1 more source

Attenuated Cardiac–Ocular Phenotype of Sanfilippo Syndrome (MPS IIIA) Presenting With Hypertrophic Cardiomyopathy and Cone-Rod Dystrophy

Annals of Internal Medicine: Clinical Cases
We describe a 39-year-old woman with cone-rod dystrophy and hypertrophic obstructive cardiomyopathy complicated by an apical aneurysm, ventricular tachycardia, and ischemic stroke, ultimately requiring heart transplantation.
Marc Vanderheyden, Gert Cypers, Sara Seneca   +2 more
doaj   +1 more source

Dual-chamber pacing and alcohol septal ablation in hypertrophic obstructive cardiomyopathy - results of long-term follow-up [PDF]

, 2013
Jan Krejčí, P Gregor, David Zemánek, Klaudia Židová, Karol Čurila, Radka Štěpánová, Miroslav Novák, Ladislav Groch, Josef Veselka   +8 more
openalex   +1 more source