Results 41 to 50 of about 306,427 (235)

Intelligent Micro/Nanorobots for Targeted Interventional Therapy: From Bench to Clinic

Advanced Robotics Research, EarlyView.
Zirui Zhang et al. reviewed the application and challenges of mobile nanomachines in interventional therapy. By converting exogenous energy, including chemical, magnetic, optical, and ultrasonic sources, into mechanical forces, micro/nanorobots (MNRs) enable precise actuation at unprecedented scales. Evolving far beyond traditional drug delivery, these
Zirui Zhang, Yu Dong, Yongsheng Du, Rui Gao, Lin Zhang, Fei Tong   +5 more
wiley   +1 more source

Hypertrophic cardiomyopathy phenotype is associated with postmyectomy change in diastolic function measured by artificial intelligence–enabled electrocardiogram

JTCVS Open
Objectives: Diastolic dysfunction may persist after septal myectomy for obstructive hypertrophic cardiomyopathy, contributing to residual or recurrent symptoms.
Julia G. Debertin, MD, MPH, Hartzell V. Schaff, MD, Masoomeh Aslahishahri, PhD, Joseph A. Dearani, MD, Steve R. Ommen, MD, Paul A. Friedman, MD, Zachi I. Attia, PhD, Tedy Sawma, MD, Konstantinos C. Siontis, MD, Eunjung Lee, PhD, Jae K. Oh, MD, Jeffrey B. Geske, MD   +11 more
doaj   +1 more source

Acute myocardial infarction occurring after hypertrophic obstructive cardiomyopathy with paroxysmal atrial fibrillation: a case report

Journal of International Medical Research, 2022
Atheromatous plaque rupture and coronary artery stenosis/occlusion are leading causes of acute myocardial infarction (AMI). Other reasons for AMI are frequently overlooked.
Dingfeng Fang, Jiabin Xu, Bo Bai, Haibo Chen   +3 more
doaj   +1 more source

The clinical characteristics of families with hypertrophic cardiomyopathy associated with mutations of cardiac myosin binding protein C [PDF]

, 2010
Introduction: Mutations in cardiac myosin binding protein-C (MYBPC3), the most common genetic cause of hypertrophic cardiomyopathy (HCM), have been reported to cause a comparatively benign and late-onset form of the disease with incomplete penetrance ...
Page, S.P.
core  

Toward replacing late gadolinium enhancement with artificial intelligence virtual native enhancement for gadolinium-free cardiovascular magnetic resonance tissue characterization in hypertrophic cardiomyopathy [PDF]

, 2021
Background: Late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) imaging is the gold standard for noninvasive myocardial tissue characterization but requires intravenous contrast agent administration.
Qiang Zhang, Iulia A. Popescu, Mayooran Shanmuganathan, Suleyman D. Polat, Ahmet Barutcu, Stefan K. Piechnik, Michael Jerosch-Herold, Vanessa M. Ferreira, Matthew K. Burrage, Hugh C. Watkins, Chrysovalantou Nikolaidou, Rebecca Mills, Evan Hann, Michael Salerno, Elena Lukaschuk, Raymond Y. Kwong, Konrad Werys, Stefan Neubauer, Christopher M. Kramer   +18 more
core   +1 more source

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

Advanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian, Jia‐Xi Gu, Zhang Yue, Chun‐Ze Yuan, Hai‐Bin Ji, Ao Li, Yu Zhong, Xiu‐Fan Xu, Yu‐Qiu He, Ye‐Fan Jiang, Hong‐Shan Chen, Xiang Chen, Meng‐Lin Chao, Yong‐Feng Shao   +13 more
wiley   +1 more source

Myocardial bridge in a child without hypertrophic cardiomyopathy: A case report

Asian Journal of Medical Sciences, 2015
In children, myocardial bridge is an inborn coronary anomaly and is usually found in the patients with hypertrophic cardiomyopathy or left ventricular hypertrophy.
Shiv Kumar Yadav
doaj   +1 more source

Role of modifying genes on the severity of rare mutation of MYH7 gene in hypertrophic obstructive cardiomyopathy

, 2012
Hypertrophic Cardiomyopathy (HCM) is an autosomal dominant disorder due to mutations in sacromeric genes with variable penetrance. Hypertrophic Obstructive Cardiomyopathy (HOCM) is a major complication of Hypertrophic Cardiomyopathy.
Das, Soumi, Biswas, Amitabh, Rao, V. R., Maulik, S. K., Seth, Sandeep, Bhargava, Balram   +5 more
core   +1 more source

Disulfide Bond–Modified Proteomics Reveals the Effects of Riboflavin on Protein Folding Dynamics

Animal Research and One Health, EarlyView.
Riboflavin deficiency impairs oxidative protein folding, causing ER misfolded protein accumulation, CHOP activation, and apoptosis, revealing a role of riboflavin in proteostasis. ABSTRACT Riboflavin is a crucial micronutrient essential for maintaining cellular homeostasis, acting as an important precursor for flavoproteins that utilize flavin ...
Bo Zhang, Shuisheng Hou, Jing Tang
wiley   +1 more source

Association between uric acid-to-albumin ratio and clinical outcomes in patients with hypertrophic cardiomyopathy: A retrospective observational study

Journal of International Medical Research
Objective To evaluate the association between the uric acid-to-albumin ratio and adverse clinical outcomes in patients with hypertrophic cardiomyopathy. Methods This retrospective, observational single-center study included 124 patients with hypertrophic
Ayşegül Ülgen Kunak, Tolga Kunak
doaj   +1 more source