Results 141 to 150 of about 52,379 (265)

Targeting the miR‐224‐5p/PTEN pathway: A previously under‐characterized strategy to attenuate mesangial cell injury and predict prognosis in diabetic nephropathy

open access: yesJournal of Diabetes Investigation, EarlyView.
Serum miR‐224‐5p levels are progressively elevated in diabetic nephropathy (DN) and serve as an independent predictor of a decline in eGFR of ≥30% over 2 years. Mechanistically, miR‐224‐5p directly targets PTEN 3’‐UTR, suppressing PTEN and the activation of the AKT pathway in high‐glucose‐stimulated mesangial cells.
Yanxia Gao   +3 more
wiley   +1 more source

MAFLD/MASLD: Past, Present, and Future

open access: yesJournal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD), also known as nonalcoholic fatty liver disease and metabolic dysfunction‐associated fatty liver disease, affects more than 30% of the global adult population and has become one of the leading causes of cirrhosis and hepatocellular carcinoma.
Vincent Wai‐Sun Wong
wiley   +1 more source

Outcomes for Frail Dialysis Patients Not Referred for Transplantation: A Cohort Study

open access: yesJournal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Frailty is highly prevalent in kidney failure, but it is unclear whether frailty impacts health outcomes for those initiating dialysis who are not referred for transplantation. Our objective was to determine if frailty is associated with death or development of a permanent contraindication to transplantation among eligible non ...
Joshua Goodwin   +6 more
wiley   +1 more source

Frailty in Adults With Down Syndrome: Cognitive, Functional and Biomarker Associations

open access: yesJournal of Intellectual Disability Research, EarlyView.
ABSTRACT Background Down syndrome (DS) entails widespread age‐related functional decline affecting multiple organ systems, including genetically determined early‐onset Alzheimer disease (DSAD), resulting in an increased vulnerability to frailty early in life.
Georg Nübling   +11 more
wiley   +1 more source

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