Results 51 to 60 of about 32,354 (195)

Mucopolysaccharidosis Type IIIB With Pancytopenia: A Case Report and Hematological Correlations in Mice

Clinical Genetics, EarlyView.
We report an individual with mucopolysaccharidosis type IIIB and chronic pancytopenia. Hematological studies in a mouse model revealed microcytic anemia and decreased monocyte count. Hence, pancytopenia is thought to be secondary to mucopolysaccharidosis type IIIB, and we suggest that a complete blood count should be included in the clinical ...
Éliane Beauregard‐Lacroix, Patricia Dubot, Alexey V. Pshezhetsky, Philippe M. Campeau   +3 more
wiley   +1 more source

Estimating the association and timing of occurrence between obesity and related comorbidity outcomes in a real‐world setting: A cohort study in the United States

Clinical Obesity, EarlyView.
Estimating the Association and Timing of Occurrence between Obesity and Related Comorbidity Outcomes in a Real‐World Setting: A Cohort Study in the United States. An observational, retrospective cohort study of adults with available body mass index (BMI) data during the period 2010–2019 in a large United States claims‐linked electronic health records ...
Firas Dabbous, Jigish Bhavsar, Jayashri Desai, Anthony Fabricatore, Bríain Ó. Hartaigh, Wojciech Michalak, Sariya Udayachalerm, Cynthia Saiontz‐Martinez, Zhenxiang Zhao, Fatima Cody Stanford   +9 more
wiley   +1 more source

Obstructive sleep apnea is associated with impaired insulin clearance and hepatic insulin sensitivity in paediatric obesity

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Obstructive sleep apnea (OSA) affects up to 40% of children and adolescents with obesity and is linked to hyperinsulinism. However, the mechanisms underpinning this association remain unclear. The study aims to assess the three key determinants of hyperinsulinemia: insulin clearance, secretion, and sensitivity in paediatric patients with ...
Giuseppina Rosaria UMANO, Francesca Aiello, Giulia Rondinelli, Alessandra Salvati, Delfina Petrone, Maria Vittoria Sibillo, Raffaella D'Ausilio, Pierluigi Marzuillo, Anna Grandone, Grazia Cirillo, Domenico Tricò, Emanuele Miraglia del Giudice   +11 more
wiley   +1 more source

Bridging the gap in obesity research: A consensus statement from the European Society for Clinical Investigation

European Journal of Clinical Investigation, EarlyView.
This consensus highlights critical research gaps in obesity epidemiology, phenotypic heterogeneity and clinical management, calling for advanced methodologies, collaborative strategies and innovative policies to mitigate the global obesity epidemic and its socio‐economic impacts.
Federico Carbone, Jean‐Pierre Després, John P. A. Ioannidis, Ian J. Neeland, Gabriella Garruti, Luca Busetto, Luca Liberale, Stefano Ministrini, Gemma Vilahur, Thomas H. Schindler, Maria Paula Macedo, Agostino Di Ciaula, Marcin Krawczyk, Andreas Geier, Gyorgy Baffy, Maria Felicia Faienza, Ilaria Farella, Nicola Santoro, Gema Frühbeck, Patricia Yárnoz‐Esquiroz, Javier Gómez‐Ambrosi, Emma Chávez‐Manzanera, Verónica Vázquez‐Velázquez, Jean‐Michel Oppert, Dimitrios N. Kiortsis, Paolo Sbraccia, Carmine Zoccali, Piero Portincasa, Fabrizio Montecucco   +28 more
wiley   +1 more source

Prevalence, Impact on Quality of Life, and Predictive Factors of Co‐Existent Overactive‐Underactive Bladder in Women

International Journal of Urology, EarlyView.
ABSTRACT Objectives To investigate the prevalence, impact on health‐related quality of life (HRQOL), and predictive factors of co‐existent overactive‐underactive bladder (COUB) in women. Methods 3088 Japanese women aged ≥ 20 years responding to a nationwide internet survey on lower urinary tract symptoms (LUTS) were included.
Noritoshi Sekido, Kenji Omae, Nobuhiro Haga, Yasue Kubota, Motoaki Saito, Ryuji Sakakibara, Mikako Yoshida, Takahiko Mitsui, Naoya Masumori, Satoru Takahashi   +9 more
wiley   +1 more source

Durability of Ultra‐Low Temperature Cryoablation Lesions in Atrial Fibrillation: Insights From Repeat Ablation Procedures

Journal of Cardiovascular Electrophysiology, Volume 36, Issue 6, Page 1264-1271, June 2025.
ABSTRACT Background Ultra‐low temperature cryoablation (ULTC) is a technique designed to rapidly cool cardiac tissue to extremely low temperatures, enabling the creation of ablation lesions for the treatment of atrial fibrillation (AF). Prior studies have demonstrated low rates of arrhythmia recurrence, but little is known about ablation lesion ...
Bob G. S. Abeln, Lucio Addeo, Tom De Potter, Lucas V. A. Boersma   +3 more
wiley   +1 more source

Clinical Phenotypes in Relation to Outcomes in Heart Failure Patients With Cardiac Resynchronization Therapy and Defibrillators (CRT‐D): An Unsupervised Cluster Analysis

Journal of Cardiovascular Electrophysiology, EarlyView.
Graphical abstract showing the 4 clusters identified in CRT‐D patients. Abstract Background Patients with heart failure undergoing cardiac resynchronization therapy (CRT) are a heterogenous and complex population. Objective To identify different clusters of patients with CRT‐D and to evaluate the associations with clinical outcomes, using cluster ...
Luigi Gerra, Tommaso Bucci, Arnaud Bisson, Alexandre Bodin, Bertrand Pierre, Giuseppe Boriani, Gregory Y. H. Lip, Laurent Fauchier   +7 more
wiley   +1 more source

Sleep habits in the pathogenesis and management of diabesity

Journal of Diabetes Investigation, EarlyView.
Sleep insufficiency is associated with weight gain, dysglycemia and adverse clinical outcomes through neurohormonal dysregulation impacting on appetite control, hedonic pathways and reward processing, and inflammation while the reasons why long sleepers have worse metabolic health remain obscure. Not only sleep duration matters, but circadian alignment
Cecilie Holm Rasmussen, Chun Kwan O, Wai Sze Chan, Faidon Magkos, Alice PS Kong   +4 more
wiley   +1 more source

Obesity and hypoxia have differential effects on myocardial innervation in the right ventricle of the male mouse heart

Journal of Anatomy, Volume 247, Issue 1, Page 134-143, July 2025.
Obesity induced by a high fat diet caused hyperinnervation of the right ventricle, whereas chronic hypoxia alone did not significantly alter right ventricular innervation. Surprisingly, chronic hypoxia attenuated the obesity‐induced changes in right ventricular innervation.
Louisa‐Chiara Mierswa, Julia Schipke, Christian Mühlfeld   +2 more
wiley   +1 more source

Implementing early detection of cognitive impairment in primary care to improve care for older adults

Journal of Internal Medicine, Volume 298, Issue 1, Page 31-45, July 2025.
Abstract Primary care is the ideal setting for early detection of mild cognitive impairment (MCI) and Alzheimer's disease and related dementias (ADRD), as it serves as the primary point of care for most older adults. With the growing aging population, reliance on specialists for detection and diagnosis is unsustainable, highlighting the need for ...
Nicole R. Fowler, Katherine A. Partrick, James Taylor, Michael Hornbecker, Kevin Kelleher, Malaz Boustani, Jeffrey L. Cummings, Tim MacLeod, Michelle M. Mielke, Jared R. Brosch, Janice Lee, Eli Shobin, James E. Galvin, Howard Fillit, Chinedu Udeh‐Momoh, Deanna R. Willis   +15 more
wiley   +1 more source