Results 91 to 100 of about 40,167 (260)

Pseudoeffective and nef classes on abelian varieties

, 2010
The cones of divisors and curves defined by various positivity conditions on a smooth projective variety have been the subject of a great deal of work in algebraic geometry, and by now they are quite well understood.
Claire Voisin, Cutkosky, Lawrence Ein, Olivier Debarre, Robert Lazarsfeld, Tankeev   +5 more
core   +1 more source

Dead Matter, Living Machines: Repurposing Crustaceans' Abdomen Exoskeleton for Bio‐Hybrid Robots

Advanced Science, EarlyView.
Crustacean exoskeletons, repurposed from food waste, are engineered into sustainable bending actuators combining biotic structure with synthetic control. The augmented exoskeletons achieve rapid and robust motion with lightweight body and can be used as part of robotic manipulators, grippers and swimmers.
Sareum Kim, Kieran Gilday, Josie Hughes
wiley   +1 more source

Data‐Driven Feedback Identifies Focused Ultrasound Exposure Regimens for Improved Nanotheranostic Targeting of the Brain

Advanced Science, EarlyView.
Machine learning models predict in real time the onset of harmful microbubble collapse during microbubble‐enhanced focused ultrasound (MB‐FUS) and enable dynamic adjustment of sonication to prevent cavitation‐induced damage. This predictive control expands the safe operating window for bloodbrain barrier opening, enhancing nanoparticle delivery and ...
Hohyun Lee, Victor Menezes, Shiqin Zeng, Chulyong Kim, Cynthia M. Baseman, Jae Hyun Kim, Samhita Padmanabhan, Pranav Premdas, Naima Djeddar, Anton Bryksin, Nikhil Pandey, Pavlos Anastasiadis, Anthony J. Kim, Tobey J. MacDonald, Chetan Bettegowda, Graeme F. Woodworth, Felix J. Herrmann, Costas Arvanitis   +17 more
wiley   +1 more source

From Covalent Traps to Fluorescent Beacons: The Expanding Arsenal of Chemical Probes for Studying Ubiquitin and Ubiquitin‐Like Proteins

Angewandte Chemie, EarlyView.
A large variety of chemistry‐based ubiquitin probes have been developed. ABSTRACT Ubiquitin (Ub) and ubiquitin‐like proteins (Ubls) orchestrate diverse cellular processes through reversible post‐translational modification of target proteins. Their conjugation is governed by a cascade of E1 activating, E2 conjugating, and E3 ligating enzymes, while ...
Saibal Chanda, Wenshe Ray Liu
wiley   +2 more sources

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Competition Between Liquid‐Liquid Crystalline Phase Separation (LLCPS) and Liquid‐Liquid Phase Separation (LLPS) in Amyloid Fibril Colloidal Systems

Advanced Science, EarlyView.
This study shows that amyloid fibrils form nematic condensates via liquid–liquid crystalline phase separation (LLCPS). With increasing pH, this transition shifts toward disordered condensates formed through liquid–liquid phase separation (LLPS), in which birefringence with lack of a coherent nematic field symmetry originates from enthalpic fibril ...
Milad Radiom, Raffaele Mezzenga
wiley   +1 more source

Mitophagy and Ubiquitination Coordinate Context‐Specific Mitochondrial Quality Control and EMT/MET Plasticity to Drive Cancer Cell Invasion

Advanced Science, EarlyView.
Metastatic invasion emerges when tumor‐intrinsic programs and microenvironmental forces converge on mitochondrial quality control. A context‐stratified framework links mtROS, mtDNA integrity, mechanics and nutrient/oxygen cues to fission–fusion remodeling, mtUPR and mitophagy.
Bin‐Hsu Mao, Bo‐Kai Su, Ying‐Jan Wang, Ting‐Yuan Tu   +3 more
wiley   +1 more source

Deformation Driven Suction Cups: A Mechanics‐Based Approach to Wearable Electronics

Advanced Science, EarlyView.
Deformation‐driven suction cups enable robust, reversible adhesion of wearable electronics to human skin spanning wide mechanical compliance, without adhesives or tight straps. By integrating mechanics modeling, experiments, and contact mechanics theory, this work reveals how cup geometry, substrate compliance, and interfacial adhesion govern suction ...
Seola Lee, Andrew Akerson, Roham Pardakhtim, Ehsan Hajiesmaili, Kevin Rhodes, Zidong Li, Andrew Stanley, Amirhossein Amini, Daniele Piazza, Chiara Daraio, Tianshu Liu   +10 more
wiley   +1 more source

High‐Conductivity Electrolytes Screened Using Fragment‐ and Composition‐Aware Deep Learning

Advanced Science, EarlyView.
We present a new deep learning framework that hierarchically links molecular and functional unit attributions to predict electrolyte conductivity. By integrating molecular composition, ratios, and physicochemical descriptors, it achieves accurate, interpretable predictions and large‐scale virtual screening, offering chemically meaningful insights for ...
Xiangwen Wang, Muyang Chen, Gengyi Bao, Yan Lai, Jinghe Cao, Xinhua Liu, Rui Tan   +6 more
wiley   +1 more source

Stage‐Specific Roles of Deep Eutectic Solvents in Recycling of Spent Lithium‐Ion Batteries

Advanced Energy Materials, EarlyView.
Deep eutectic solvents (DESs) offer tunable acidity, redox, and coordination properties for selective recycling of spent lithium‐ion battery cathodes. Through co‐dissolution, single‐ and two‐metal separations, DESs enable sustainable recovery of critical metals for closed‐loop regeneration of battery‐grade materials, advancing a circular economy for ...
Jingxiu Wang, Yan Wang, Yanqiu Lyu, Jianfeng Mao, Zaiping Guo   +4 more
wiley   +1 more source