Results 41 to 50 of about 505,349 (318)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Effect of Herbal Toothpaste Without Fluoride Against Candida Albicans and Streptococcus Mutans: An In Vitro Study

Journal of Health Science and Medical Research (JHSMR)
Objective: This study aimed to evaluate the antimicrobial effects of herbal toothpaste without fluoride on Candida albicans ATCC 90028 (C. albicans ATCC 90028) and Streptococcus mutans ATCC 25175 (S. mutans ATCC 25175).
Natrapee Akarathanakrit, Nattapon Rotpenpian, Suwanna Jitpukdeebodintra   +2 more
doaj   +1 more source

Acute Effect of Repeated Sprint Exercise With Blood Flow Restriction During Rest Periods on Muscle Oxygenation

Frontiers in Physiology, 2021
PurposeThis study aimed to examine the effect of applying BFR during rest periods of repeated cycling sprints on muscle oxygenation.MethodsSeven active males performed 5 × 10-s maximal pedaling efforts with 40-s passive rest, with or without BFR ...
Chihiro Kojima, Keiichi Yamaguchi, Hiroto Ito, Nobukazu Kasai, Olivier Girard, Kazushige Goto   +5 more
doaj   +1 more source

Effect of propranolol on regional myocardial function in anesthetized open-chest dogs with myocardial ischemia

, 1978
Effects of propranolol on ischemic segmental function were studied in anesthetized open-chest dogs. Two segment-length gauges were used for measuring the regional myocardial function: one was sutured on to the left ventricular surface perfused by the ...
Yoshida, Hidenori, Ikenaga, Toyotake, Ueda, Minoru, Ogino, Yasuhiro, Haraoka, Shoichi, Tawara, Ritsuya, Yoshioka, Nobuhiko, Saito, Daiji   +7 more
core   +1 more source

Contrast-enhanced CMR in patients after percutaneous closure of the left atrial appendage: A pilot study [PDF]

, 2011
Background To evaluate the feasibility and value of first-pass contrast-enhanced dynamic and post-contrast 3D CMR in patients after transcatheter occlusion of left atrial appendage (LAA) to identify incorrect placement and persistent leaks.
Steffen E Petersen, Petersen, SE, Mohrs, OK, Nina Wunderlich, Anselm Pottmeyer, Petersen Steffen E, Wunderlich, N, Pottmeyer, A, Hans-Ulrich Kauczor, Mohrs Oliver K, Pottmeyer Anselm, Kauczor, HU, Wunderlich Nina, Kauczor Hans-Ulrich, Oliver K Mohrs   +14 more
core   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Ear symptoms in patients with orofacial pain and dysfunction ‐ An explorative study on different TMD symptoms, occlusion and habits

Clinical and Experimental Dental Research, 2021
Objectives Ear symptoms coincident with TMD symptoms have been noticed for a long time. The aim was to investigate the relationship between reported ear symptoms in TMD patients and different TMD symptoms, dental occlusion, oral parafunction and habits ...
Christina Mejersjö, Nina Pauli
doaj   +1 more source

Bilateral retinal artery occlusion; A retrospective analysis of clinical presentation and management

Kerala Journal of Ophthalmology, 2023
Purpose: Retinal artery occlusion (RAO) is an ophthalmologic emergency and involvement of both eyes is rare. The aim of this study was to determine the pattern of presentation of bilateral RAO in south India and the associated systemic disorders. Methods:
Jayant Kumar, Olukorede O Adenuga, Deepesh Chhablani, Haemoglobin Parida, Sabareesh Muraleedharan, Naresh B Kannan, Kim Ramasamy   +6 more
doaj   +1 more source

Correlation of inflammatory and proangiogenic cytokines from undiluted vitreous samples with spectral domain OCT scans, in untreated branch retinal vein occlusion

, 2013
Purpose: To assess the levels of inflammatory and angiogenic cytokines in undiluted vitreous from treatment-naïve patients with macular edema secondary to nonischemic branch retinal vein occlusion (BRVO), with flow cytometric bead array (CBA) and to ...
Michaelis, Martin, Cinatl, Jindrich, Koch, Frank H., Schubert, Ralf, Koss, Michael J, Pfister, Marcel, Rothweiler, Florian, Koch, Frank H, Koss, Michael Janusz   +8 more
core   +1 more source