Results 51 to 60 of about 2,743,630 (241)

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

A Computational Analysis for Active Flow and Pressure Control Using Moving Roller Peristalsis

Computation, 2021
Peristaltic motion arises in many physiological, medical, pharmaceutical and industrial processes. Control of the fluid volume rate and pressure is crucial for pumping applications, such as the infusion of intravenous liquid drugs, blood transportation ...
Iosif Moulinos, Christos Manopoulos, Sokrates Tsangaris   +2 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Probing expert anticipation with the temporal occlusion paradigm: Experimental investigations of some methodological issues [PDF]

, 2005
Copyright @ 2005 Human KineticsTwo experiments were conducted to examine whether the conclusions drawn regarding the timing of anticipatory information pick-up from temporal occlusion studies are influenced by whether (a) the viewing period is of ...
Jackson, RC, Farrow, D, Abernethy, B
core   +3 more sources

No acute differences in anaerobic performance following autoregulated vs non-autoregulated blood flow restricted resistance exercise

Turkish Journal of Kinesiology
This study aimed to investigate the acute effects of autoregulated and non-autoregulated blood flow restricted resistance exercise on Wingate anaerobic performance test metrics.
Okan Kamiş, Kadir Keskin, Cem Sofuoğlu, Neslihan Akçay   +3 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Postreperfusion Blood Pressure Variability After Endovascular Thrombectomy Affects Outcomes in Acute Ischemic Stroke Patients With Poor Collateral Circulation

Frontiers in Neurology, 2019
Background and Purpose: We evaluated the effect of 24 h blood pressure variability (BPV) on clinical outcomes in acute ischemic stroke patients with successful recanalization after endovascular recanalization therapy (ERT).Methods: Patients with anterior
Jun Young Chang, Sang-Beom Jeon, Cheolkyu Jung, Dong Seok Gwak, Moon-Ku Han, Moon-Ku Han   +5 more
doaj   +1 more source

A surgical model of permanent and transient middle cerebral artery stroke in the sheep. [PDF]

PLoS ONE, 2012
BACKGROUND: Animal models are essential to study the pathophysiological changes associated with focal occlusive stroke and to investigate novel therapies.
Adam J Wells, Robert Vink, Peter C Blumbergs, Brian P Brophy, Stephen C Helps, Steven J Knox, Renée J Turner   +6 more
doaj   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Development and usability testing of a preliminary web-based application for the clinical implementation of blood flow restriction: a mixed methods pilot study

Frontiers in Physiology
IntroductionExercise with blood flow restriction (BFR) has gained popularity for use with a wide range of healthy and clinical populations. However, several factors including medical screening, selection of equipment, and determination of cuff pressure ...
Isaac J. Wedig, Isaac J. Wedig, Isaac J. Wedig, Erich J. Petushek, Erich J. Petushek, John J. Durocher, John McDaniel, Steven J. Elmer   +7 more
doaj   +1 more source