Results 281 to 290 of about 205,837 (394)

Targeting DESI2 as a Novel Therapeutic Strategy for JAK2‐Mutant Leukemias

Advanced Science, EarlyView.
Mass spectrometry‐based proteomics identify DESI2 as a novel component of the JAK2‐V617F complex, which associates with and stabilizes mutant JAK2 through deSUMOylation and deubiquitination, therefore promoting JAK2 mutant cell growth and MPN disease onset in vivo.
Husheng Mei, Wuqiang Wen, Wenjun Zhang, Shujing Zhang, Ting Sun, Guiming Li, Jing Zhang, Shuang Qi, Jie Zhou, Bing Li, Yunshuo Zhao, Xiaotong Chen, Bowen Li, Yiying Xue, Wang Lu, Yanli Sun, Jingyao Wang, Hengyue Shan, Shengzhe Zhang, Yushan Huang, Yisa Chen, Wenchao Wang, Qingsong Liu, Wenchao Lu, Li Tan, Yi Ding, Jianfei Fu, Jun Long, Lei Zhang, Baobing Zhao, Aibin Liang, Baishan Jiang, Jing Yang   +32 more
wiley   +1 more source

Orbital vaso-occlusive crisis mimicking an abscess in pediatric sickle cell disease: A diagnostic pitfall. [PDF]

Radiol Case Rep
Fong DC, Gocal WA, Isaiah A.
europepmc   +1 more source

Anatomical significance in aortoiliac occlusive disease

Clinical anatomy (New York, N.Y. Print), 2014
Candace Wooten, Munawar Hayat, M. Plessis, Alper Cesmebasi, M. Koesterer, K. Daly, P. Matusz, R. Tubbs, M. Loukas   +8 more
semanticscholar   +1 more source

Brd4 BD1 Domain Antagonism of MS436 Preserves Blood‐Brain Barrier Integrity via Rnf43/β‐Catenin Signaling Pathway

Advanced Science, EarlyView.
MS436 competitively binds to the BD1 domain of Brd4, thereby suppressing Brd4 induced degradation of tight junction proteins via the Rnf43‐Fzd4‐β‐catenin signaling pathway. Consequently, this attenuation of degradation reduces blood‐brain barrier leakage, leading to an improved overall prognosis after stroke.
Chenxiao Li, Xiaochen Zhang, Jiangwei Xia, Shuang Liu, Yushan Du, Sihan Li, Shukui Zhang, Yong Zhang, Fen Ji, Jianwei Jiao, Jingjing Zhang   +10 more
wiley   +1 more source

A revised concept of moyamoya vasculopathy: developmental origins and genetic insights. [PDF]

Front Neurol
Ota T.
europepmc   +1 more source

Hepatic veno-occlusive disease following stem cell transplantation: incidence, clinical course, and outcome.

Biology of Blood and Marrow Transplantation, 2010
J. Coppell, P. Richardson, R. Soiffer, P. Martin, N. Kernan, Allen R. Chen, E. Guinan, G. Vogelsang, A. Krishnan, S. Giralt, C. Revta, N. Carreau, M. Iacobelli, E. Carreras, T. Ruutu, T. Barbui, J. Antin, D. Niederwieser   +17 more
semanticscholar   +1 more source

DNA Nanoflower LYTACs Enable Efficient VEGF Degradation and Verteporfin Loading for Combined Therapy of Wet Age‐Related Macular Degeneration

Advanced Science, EarlyView.
An integrated approach that combines a DNA nanoflower VEGF degrader with photodynamic therapy is developed for the treatment of wet age‐related macular degeneration, which reduces the risk of VEGF reactivation‐induced CNV recurrence and minimizes the systemic side effects associated with photodynamic therapy.
Mengxuan Li, Yan Yue, Sijin Wu, Xinyu He, Jiayi Song, Shuwen Ma, Haokun Zhang, Chenyu Xu, Song Chen, Yanming Huang, Songbo Xie, Hua Yan   +11 more
wiley   +1 more source

Cytomegalovirus retinitis (CMVR) in an HIV-negative patient with a history of chronic lymphoproliferative disease. [PDF]

J Ophthalmic Inflamm Infect
Lukic M, Yeung I, Qing L, Westcott M.
europepmc   +1 more source

The Influence of Experience on the Reproducibility of the Ankle–brachial Systolic Pressure Ratio in Peripheral Arterial Occlusive Disease

, 1999
Victor Kaiser, Arnold D.M. Kester, Jelle Stoffers, Peter J.E.H.M. Kitslaar, J. André Knottnerus   +4 more
openalex   +1 more source