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Prevalence of occult HBV infection in Western countries

Journal of Medical Virology, 2020
AbstractDue to a lack of standardized tests, it is difficult to obtain prevalence data and define the real impact of occult HBV infection (OBI) in Western countries. The present review article addresses the prevalence of OBI, defined as presence of hepatitis B virus (HBV) DNA in liver tissue or plasma in HBsAg‐negative subjects, in Western countries ...
mariantonietta Pisaturo   +2 more
exaly   +4 more sources

Role of core protein mutations in the development of occult HBV infection

Journal of Hepatology, 2021
Occult HBV infection (OBI) is associated with transfusion-transmitted HBV infection and hepatocellular carcinoma. Studies on OBI genesis have concentrated on mutations in the S region and the regulatory elements. Herein, we aimed to determine the role of mutations in the core region on OBIs.An OBI strain (SZA) carrying 9 amino acid (aa) substitutions ...
Bochao Liu, Ling Zhang, Wenjing Wang
exaly   +4 more sources

Clinical impact of occult HBV infections

Journal of Clinical Virology, 2005
HBV infection in the absence of HBsAg has been a matter of debate for years, but its existence and clinical relevance are now supported by many publications, editorials and reviews. HBV DNA without HBs antigenemia was detected in the following clinical situations: (1) Chronic, presumably viral, hepatitis unrelated to HCV, atypical alcoholic hepatitis ...
I, Chemin, C, Trépo
openaire   +2 more sources

Occult HBV infection in the oncohematological setting

Infection, 2016
Occult hepatitis B infection (OBI), a virological condition characterized by a low release of Hepatitis B Virus (HBV) from liver cells and low HBV-DNA levels in serum and/or liver tissue of HBsAg-negative subjects, may reactivate in oncohematological patients undergoing immunosuppression by aggressive chemotherapy or hematopoietic stem cell ...
SAGNELLI, Caterina   +5 more
openaire   +3 more sources

Occult HBV infection in cryptogenic liver cirrhosis in an area with high prevalence of HBV infection

The American Journal of Gastroenterology, 2002
Hepatitis B surface antigen (HBsAg) is often used as the serological marker to screen for hepatitis B virus (HBV) infection in the investigation of liver cirrhosis. In Hong Kong, where HBV infection is endemic, some patients may have persistent viral infection after the loss of HBsAg. We aimed to investigate 1) the prevalence of occult HBV infection in
Henry Lik-Yuen, Chan   +7 more
openaire   +3 more sources

The role of HBV cccDNA in occult hepatitis B virus infection

Molecular and Cellular Biochemistry, 2023
Occult hepatitis B virus (HBV) infection (OBI) refers to the presence of replication-competent HBV DNA in the liver, with or without HBV DNA in the blood, in individuals who tested negative for HBV surface antigen (HBsAg). In this peculiar phase of HBV infection, the covalently closed circular DNA (cccDNA) is in a low state of replication.
Pei, He   +8 more
openaire   +2 more sources

Occult HBV Infection in Multi Transfused Thalassemia Patients

The Indian Journal of Pediatrics, 2014
To determine the prevalence of Hepatitis B virus (HBV) and Hepatitis C virus (HCV) infection in multitransfused thalassemic patients, with an aim to further highlight the need for donor screening strategy with supplementary molecular diagnostic tools for high risk population.The study was conducted in 174 thalassemic subjects from Thalassemia unit of ...
Jyotsna, Sabat   +3 more
openaire   +2 more sources

Epidemiology of HBV infection in Asian blood donors: Emphasis on occult HBV infection and the role of NAT

Journal of Clinical Virology, 2006
Hepatitis B virus (HBV) infection is endemic in many Asian countries. Among many transmission routes, transfusion is the one that should be prevented. The first major success in enhancing transfusion safety came with the implementation of hepatitis B surface antigen (HBsAg) in the early 1970s. However, the studies quoted in this review demonstrate that
Chun-Jen, Liu   +2 more
openaire   +2 more sources

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