Results 151 to 160 of about 11,436,233 (262)

Lactate‐Induced K370 Lactylation of STING Inhibits STING‐TBK1 Signaling and Dampens Anti‐Tumor Immunity

Advanced Science, EarlyView.
Lactate accumulation in glioblastoma drives lactylation of STING at lysine 370, a primate‐conserved residue. K370 lactylation weakens STING‐TBK1 binding, destabilizes STING, and disrupts ER‐to‐Golgi trafficking, blunting type I interferon signaling. LDHA inhibition reverses K370 lactylation and improves the antitumor efficacy of STING agonism combined ...
Yueyao Wu, Jingzhe Wang, Xu Chen, Yuntong Yang, Ping Wei, Han Xie, Honghao Wang, Chunyu Zhang, Siyi Xu, Qi Wang, Chunlong Zhong, Jing Zhang   +11 more
wiley   +1 more source

Occult Pathology in the Contralateral Prophylactic Mastectomy Specimen Despite a Negative Contralateral MRI: A Single-Center Cohort Study. [PDF]

Cancers (Basel)
Yılmaz OC, Gündoğdu A, Aktaş M, Ertekin K, Tokoçin M, Gentile D, Sönmez Wetherilt C, Çelik L.   +7 more
europepmc   +1 more source

Chadwick (Henry) Priscillian of Avila: the Occult and the Charismatic in the Early Church

, 1977
Séguy Jean. Chadwick (Henry) Priscillian of Avila: the Occult and the Charismatic in the Early Church. In: Archives de sciences sociales des religions, n°43/2, 1977. pp.
Séguy, Jean
core  

Low SLC8A1 in Colorectal Cancer Dictates Radiotherapy Resistance Through Calcium‐Dependent ANXA2+sEVs Driving M2 Polarization of TAMs

Advanced Science, EarlyView.
SLC8A1 deficiency in colorectal cancer cells increases intracellular calcium signaling, promoting the secretion of ANXA2‐enriched small extracellular vesicles. These vesicles reprogram tumor‐associated macrophages towards an M2 phenotype, which in turn fosters a tumor microenvironment conducive to radioresistance and is associated with poor patient ...
Yimin Fang, Jinghan Zhu, Qian Xiao, Qichun Wei, Xiujing He, Ping Li, Kai Jiang, Yue Liu, Yeting Hu, Weiwei Yu, Chuansheng Guo, Sheng Chen, Jian Zhao, Siqi Dai, Jingsun Wei, Hang Yang, Tongtong Bu, Kefeng Ding, Haiyan Chen   +18 more
wiley   +1 more source

Occult ascending pharyngeal artery pseudoaneurysm masked by CTA artifact after penetrating facial trauma: a case report. [PDF]

J Surg Case Rep
Hadji S, Pate JD, Jones C, Kaparthi J, Talukdar N, Do B.   +5 more
europepmc   +1 more source

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

Deep-learning-enabled multi-omics analyses for prediction of future metastasis in cancer. [PDF]

Nat Commun
Wang X, Duan M, Snyder AJ, Su PL, Li J, Krull J, Jin J, Xu Y, Sun Y, Chen H, Wu W, Chen W, He K, Zhang C, Cao S, Zhao J, Xu D, Wang G, Li L, Xin G, Carbone DP, Li Z, Carpenter RL, Ma Q.   +23 more
europepmc   +1 more source

A Photothermally Amplified Enzyme–Nitric Oxide Co‐Regulatory System Reprograms Pathological ECM–Fibroblast Crosstalk to Alleviate Hypertrophic Scarring

Advanced Science, EarlyView.
An enzyme–nitric oxide (NO) co‐regulatory strategy reprograms pathological extracellular matrix (ECM)–fibroblast crosstalk in hypertrophic scars. Enzymatic degradation of pre‐existing ECM relieves aberrant mechanical cues, while NO‐mediated fibroblast phenotypic modulation restrains excessive collagen synthesis.
Junzhe Fu, Fan Jia, Yixian Mu, Wanzhe Liu, Dingqi Tang, Qiao Jin, Jian Ji, Youxiang Wang   +7 more
wiley   +1 more source

Stress Fracture Along with Transient Osteoporosis in a 72-Year-Old Female with Hip Pain: A Case Report

Orthopedic Research and Reviews
Khalil Kargar Shooraki,1 Arash Aris,1,2 Masih Rikhtehgar3 1Bone and Joint Reconstruction Research Center, Department of Surgery, Shafa Yahyaeian Orthopedic Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; 2Department of ...
Kargar Shooraki K, Aris A, Rikhtehgar M
doaj  

Prevalence of Occult Macular Pathologies Detected by Optical Coherence Tomography in Patients Scheduled for Cataract Surgery. [PDF]

Beyoglu Eye J
Yılmaz AC, Mutlu FM.
europepmc   +1 more source