Results 151 to 160 of about 43,547 (259)

Comment on “Fecal occult blood versus DNA testing: indirect comparison in a colorectal cancer screening population”

open access: yesClinical Epidemiology, 2017
David A Ahlquist Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USAChallenges to medical innovation are welcome and essential elements in the dialectic toward practice optimization but must be based on scientifically sound ...
Ahlquist DA
doaj  

Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development

open access: yesAdvanced Science, EarlyView.
The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu   +12 more
wiley   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

open access: yesAdvanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao   +16 more
wiley   +1 more source

Detection of Protein–Protein Interactions in Escherichia coli With Single Molecule Sensitivity

open access: yesAdvanced Science, EarlyView.
This article describes a regulatory circuit in Escherichia coli able to detect protein–protein interactions with exquisite sensitivity. The interaction between two hybrid proteins fused to Bordetella pertussis adenylate cyclase and its activator calmodulin triggers a potent cyclic AMP signaling cascade.
Marilyne Davi, Daniel Ladant
wiley   +1 more source

Occult Sciences in Ottoman Knowledge

open access: yes
Abstract In this chapter, the focus is on the field of magic or rather of occult sciences: that is, the ways and practices of connecting with the supernatural, conceptualizing, explaining, and even controlling it. The chapter deals with the theory of the occult, analysing the terminology concerning magic and the position sciences such
openaire   +1 more source

Temporal and Cell‐Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1

open access: yesAdvanced Science, EarlyView.
Chd1, the Drosophila homologue of mammalian CHD2 ‐ a gene linked to autism, epilepsy, and intellectual disability, is required for synaptic homeostatic plasticity. Chd1 in glia is necessary for the rapid induction of synaptic homeostasis, whereas Chd1 in motoneurons, muscle, and glia is critical for long‐term maintenance.
Danielle T. Morency   +19 more
wiley   +1 more source

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

open access: yesAdvanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao   +11 more
wiley   +1 more source

Stress Fracture Along with Transient Osteoporosis in a 72-Year-Old Female with Hip Pain: A Case Report

open access: yesOrthopedic Research and Reviews
Khalil Kargar Shooraki,1 Arash Aris,1,2 Masih Rikhtehgar3 1Bone and Joint Reconstruction Research Center, Department of Surgery, Shafa Yahyaeian Orthopedic Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran; 2Department of ...
Kargar Shooraki K, Aris A, Rikhtehgar M
doaj  

Home - About - Disclaimer - Privacy