Results 131 to 140 of about 2,013 (259)

Tumor‐Specific Delivery of CD28 siRNA via Lyso‐PC C‐16 Modified Lipid Nanoparticles Overcomes Anti‐PD‐1 Resistance by Remodeling Tumor Microenvironment

Advanced Science, EarlyView.
This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai, Keyu Wang, Jiali Fang, Shaorui Jia, Yansong Shi, Wanfeng Gao, Xinpeng Liu, Jiaqiang Li, Zenghui Cui, Yazhi Qian, Xiaosu Chen, Dan Ding, Xuetao Cao   +12 more
wiley   +1 more source

Occultation constraints on solar system formation models. [PDF]

Philos Trans A Math Phys Eng Sci
Buie MW, Keller JM, Nesvorný D, Porter SB.   +3 more
europepmc   +1 more source

Global Vertical Distribution of Water Vapor on Mars: Results From 3.5 Years of ExoMars-TGO/NOMAD Science Operations. [PDF]

J Geophys Res Planets, 2022
Aoki S, Vandaele AC, Daerden F, Villanueva GL, Liuzzi G, Clancy RT, Lopez-Valverde MA, Brines A, Thomas IR, Trompet L, Erwin JT, Neary L, Robert S, Piccialli A, Holmes JA, Patel MR, Yoshida N, Whiteway J, Smith MD, Ristic B, Bellucci G, Lopez-Moreno JJ, Fedorova AA.   +22 more
europepmc   +1 more source

Generation of Self‐Organizing Macrovascular Constructs by Bioprinting Human iPSC‐Derived Mesodermal Progenitor Cells

Advanced Science, EarlyView.
ABSTRACT Vascularization remains a major obstacle in tissue engineering. Here, we introduce a bioprinting strategy to generate centimeter‐scale, self‐organizing “mother vessel” constructs from iPSC‐derived hiMPCs. By optimizing bioink composition, printing was accomplished in a single‐step approach. Within one week, hiMPCs differentiated into both CD31+
Leyla E. Dogan, Nathaly A. Chicaiza‐Cabezas, Florian Kleefeldt, Philipp Wörsdörfer, Jürgen Groll, Süleyman Ergün   +5 more
wiley   +1 more source

The hidden mysteries of our ice giant planets. [PDF]

Nat Commun
de Villa K, Ge H.
europepmc   +1 more source

RBM12 Maintains Glioma Stem Cells by Activating Amino Acid‐Dependent mTORC1 Signaling via SLC7A5 mRNA Stabilization

Advanced Science, EarlyView.
This study shows that in glioma stem cells (GSCs), RBM12 recruits ALKBH5 to remove m6A from SLC7A5 transcripts, thereby enhancing mRNA stability, which elevates large neutral amino acid (LNAA) levels and activates mTORC1, promoting GSC proliferation, self‐renewal, and tumor growth.
Hong Lei, Wenlong Luo, Shu Zhou, Lihao Wan, Peng Ling, Zhihua Huang, Zhihua Qian, Chenfei Lu, Mengyue Guo, Zhen Xue, Jun Qin, Ningwei Zhao, Jianghong Man, Wenchao Zhou, Zhiqiang Dong, Shutong Xu, Zhipeng Zhou, Xiuxing Wang, Weiwei Tao   +18 more
wiley   +1 more source

Evidence of an enhanced near-surface ozone layer at tropical latitudes on Mars. [PDF]

Proc Natl Acad Sci U S A
Viúdez-Moreiras D, Smith MD, Wolff M, Brown MAJ, Daerden F, Zorzano MP, Apestigue V, Arruego I, García E, Jiménez JJ, Toledo D, Lemmon MT, Knutsen EW, Saiz-Lopez A.   +13 more
europepmc   +1 more source

Observation based climatology Martian atmospheric waves perturbation Datasets. [PDF]

Sci Data, 2023
Zhang J, Ji Q, Sheng Z, He M, He Y, Zuo X, He Z, Qin Z, Wu G.   +8 more
europepmc   +1 more source

Stromal Regulation of Tumor Perineural Invasion: A Multicellular and Neuro‐Ecological Perspective

Advanced Science, EarlyView.
This review reframes perineural invasion (PNI) as a dynamic, multicellular process within the tumor–nerve–stromal ecosystem. The authors delineate how cancer‐associated fibroblasts, Schwann cells, and immune cells remodel the neural niche to facilitate tumor spread.
Xiaoyang Lin, Yingqiao Liu, Haitao Lin, Kang Feng, Xiqiang Liu   +4 more
wiley   +1 more source

Geodetic Investigations of the Europa Clipper Mission. [PDF]

Space Sci Rev
Steinbrügge G, Park RS, Roberts JH, Bland M, Brooks S, Castillo-Rogez J, Cascioli G, Genova A, Greathouse T, Hussmann H, Kirk R, Magnanini A, Mazarico E, Nimmo F, Park MS, Petricca F, Retherford K, Schroeder DM, Soderlund KM, Tortora P, Zannoni M.   +20 more
europepmc   +1 more source