Results 141 to 150 of about 502 (244)

DRD2 Deficiency Underlies Pituitary Adenoma Dependent on Escherichia coli Translocation from the Gut

Advanced Science, EarlyView.
Dopamine receptor D2 (DRD2) deficiency disrupts epithelial barrier integrity in both the gut and pituitary gland, facilitating translocation of gut‐derived Escherichia coli into pituitary tissue. Intratumoral E. coli are phagocytosed by microglia, triggering GSDMD‐dependent pyroptosis and HMGB1 release, which subsequently activates MAPK signaling to ...
Xian‐jun Su, Li Ma, Xi Xiong, Jun‐hua Meng, Qi Wu, Yu Zhang, Shu‐guang Dong, Yue‐fei Wang, Jin‐hu Wu, Qing‐yuan Zeng, Hong‐feng Zhang, Li‐li Li, Liang Meng, Min Peng, Xiao‐dong Huang, Li‐quan Wu, Xiong Wang   +16 more
wiley   +1 more source

Assessing the Accuracy of Global HFC-134a Satellite Observations from Atmospheric Chemistry Experiment Fourier Transform Spectrometer (ACE-FTS) via Aircraft, Balloon, and Model Comparisons. [PDF]

Environ Sci Technol
Li Y, Li J, Chen Y, Zhang L, Montzka SA, Vimont I, Crotwell M, Liu S, Li X, Fu W, Zhang P, Zhang X, Wu X, Zhang J, Huang Y, Luan X, Shen H, Ye J, Wang C, Yang X, Fu TM, Zhu L.   +21 more
europepmc   +1 more source

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

A Confidence-Based Multibody Kinematics Optimization for Markerless Motion Capture: A Proof of Concept. [PDF]

Int J Numer Method Biomed Eng
Chaumeil A, Puchaud P, Muller A, Dumas R, Robert T.   +4 more
europepmc   +1 more source

Derivation of global ionospheric Sporadic E critical frequency (f _o Es) data from the amplitude variations in GPS/GNSS radio occultations. [PDF]

R Soc Open Sci, 2020
Yu B, Scott CJ, Xue X, Yue X, Dou X.
europepmc   +1 more source

Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development

Advanced Science, EarlyView.
The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu, Yanzhi Feng, Qingqing Zhu, Ting Jiang, Yueyue Gao, Kebing Nie, Xianan Tang, Ying Chen, Dianxing Hu, Xudan Yang, Shixuan Wang, Meng Wu, Jinjin Zhang   +12 more
wiley   +1 more source

Occult

, 2021
openaire   +2 more sources

Astronomical Observations in Support of Planetary Entry-Probes to the Outer Planets. [PDF]

Space Sci Rev
Buratti BJ, Orton GS, Roman MT, Momary T, Bauer JM.   +4 more
europepmc   +1 more source

Astrocyte Enrichment of 3D Cortical Constructs Enhances Brain Repair

Advanced Science, EarlyView.
This study highlights the role of astrocytes in supporting neural progenitor cell survival and differentiation after traumatic brain injury. Astrocytes enhanced neuronal differentiation, improved cell survival in co‐cultures, and promoted integration of microfluidics‐based implants with host tissue following implantation. Additionally, increased axonal
Elisa M. Cruz, Luana C. Soares, Gretchen Greene, Fernando Messore, Mohammed Abuelem, Mingyu Li, Caroline Andersen, Mirriam Domocos, Elisa Vitiello, Rabeah Abdul Razak, Marlene Lawston, Gabriel Moser, Talia Vasaturo‐Kolodner, Mona Barkat, Roslyn M. Bill, Edward Mann, Linna Zhou, Mootaz M. Salman, Hagan Bayley, Zoltán Molnár, Francis G. Szele   +20 more
wiley   +1 more source

Spectroscopic insights into the near-earth didymos-dimorphos binary system following the double asteroid redirection test (DART) mission impact. [PDF]

Nat Commun
Lazzarin M, La Forgia F, Farina A, Migliorini A, Frattin E, Ochner P, Michel P, Kueppers M, de Leon J, Carnelli I, Ulamec S, Chabot N, Ammannito E, Amoroso M, Geier S, Hirabayashi M, Kareta T, Li JY, Mura AC, Oszkiewicz D, Popescu M, Rivkin AS.   +21 more
europepmc   +1 more source