Results 151 to 160 of about 502 (244)

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

X-ray astronomy from the lunar surface. [PDF]

Philos Trans A Math Phys Eng Sci
Gandhi P.
europepmc   +1 more source

Cancer Cell‐Intrinsic Cholesterol Induces Lipid‐Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression

Advanced Science, EarlyView.
Cancer cell‐intrinsic cholesterol promotes the S‐palmitoylation of SP1, increasing its nuclear translocation and driving the transcription and secretion of MDK, which in turn facilitates the differentiation of macrophages into a lipid‐associated phenotype.
Shirong Peng, Weilong Lin, Zean Li, Ruilin Zhuang, Shengmeng Peng, Bingheng Li, Bingliang Chen, Yong Luo, Yuan Ou, Wei Zhuang, Tao Du, Kaiwen Li, Hai Huang   +12 more
wiley   +1 more source

On the coincidence between the close passage of HD7977 and the Pliocene-Pleistocene transition. [PDF]

Sci Rep
Cao Z, Loeb A, MacLeod M.
europepmc   +1 more source

A review of Morlet wavelet analysis of radial profiles of Saturn's rings. [PDF]

Philos Trans A Math Phys Eng Sci, 2018
Tiscareno MS, Hedman MM.
europepmc   +1 more source

Temporal and Cell‐Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1

Advanced Science, EarlyView.
Chd1, the Drosophila homologue of mammalian CHD2 ‐ a gene linked to autism, epilepsy, and intellectual disability, is required for synaptic homeostatic plasticity. Chd1 in glia is necessary for the rapid induction of synaptic homeostasis, whereas Chd1 in motoneurons, muscle, and glia is critical for long‐term maintenance.
Danielle T. Morency, Tao Cui, Yimei Cai, Chloe Lok, Rachel E. Nokku, Ruoxian Huang, Grace L. Chu, Yumeng Xie, Saleem W. Abu‐Tayeh, Kaikai He, Chengjie Qiu, Junyi Wang, Paxton M. Paganelli, Ting Wang, Gabrielle Williams, Sreejith Nair, Huadong Pei, Dion K. Dickman, Stefano Vicini, Tingting Wang   +19 more
wiley   +1 more source

A Mussel‐Inspired Bioadhesive Patch to Selectively Kill Glioblastoma Cells

Advanced Science, EarlyView.
An innovative mussel‐inspired bioadhesive patch has been developed for post‐surgical glioblastoma treatment. The patch, which adheres strongly in biological environments, releases a localized treatment. This treatment, acting via reactive oxygen species, shows specific toxicity to glioblastoma cells.
Jose Bolaños‐Cardet, Sara Pugliese, Jordi Bruna, Daniel Ruiz‐Molina, Salvio Suárez‐García, Victor J. Yuste   +5 more
wiley   +1 more source

A contact binary satellite of the asteroid (152830) Dinkinesh. [PDF]

Nature
Levison HF, Marchi S, Noll KS, Spencer JR, Statler TS, Bell JF, Bierhaus EB, Binzel R, Bottke WF, Britt D, Brown ME, Buie MW, Christensen PR, Dello Russo N, Emery JP, Grundy WM, Hahn M, Hamilton VE, Howett C, Kaplan H, Kretke K, Lauer TR, Manzoni C, Marschall R, Martin AC, May BH, Mottola S, Olkin CB, Pätzold M, Parker JW, Porter S, Preusker F, Protopapa S, Reuter DC, Robbins SJ, Salmon J, Simon AA, Stern SA, Sunshine JM, Wong I, Weaver HA, Adam C, Ancheta S, Andrews J, Anwar S, Barnouin OS, Beasley M, Berry KE, Birath E, Bolin B, Booco M, Burns R, Campbell P, Carpenter R, Crombie K, Effertz M, Eifert E, Ellis C, Faiks P, Fischetti J, Fleming P, Francis K, Franco R, Freund S, Gallagher C, Geeraert J, Gobat C, Gorgas D, Granat C, Gray S, Haas P, Harch A, Hegedus K, Isabelle C, Jackson B, Jacob T, Jennings S, Kaufmann D, Keeney BA, Kennedy T, Lauffer K, Lessac-Chenen E, Leonard R, Levine A, Lunsford A, Martin T, McAdams J, Mehall G, Merkley T, Miller G, Montanaro M, Montgomery A, Murphy G, Myers M, Nelson DS, Ocampo A, Olds R, Pelgrift JY, Perkins T, Pineau J, Poland D, Ramanan V, Rose D, Sahr E, Short O, Solanki I, Stanbridge D, Sutter B, Talpas Z, Taylor H, Treiu B, Vermeer N, Vincent M, Wallace M, Weigle G, Wibben DR, Wiens Z, Wilson JP, Zhao Y.   +118 more
europepmc   +1 more source

Pathogenic Role of FGFR3 Autoantibodies in Small Fiber Neuropathy

Advanced Science, EarlyView.
Autoantibodies against fibroblast growth factor receptor 3 (FGFR3) are identified as pathogenic drivers of pain in small fiber neuropathy. By binding to sensory neurons in dorsal root ganglia, FGFR3 autoantibodies activate MAPK signaling and induce hyperexcitability and mechanical hypersensitivity, establishing FGFR3 autoantibodies as a therapeutic ...
Lyuba Y. Salih, Nicolas L.A. Dumaire, Clémence Gieré, Erin Vest, Haya Alkhateeb, Christian P. Moritz, Yannick Tholance, Jean‐Philippe Camdessanché, Jean‐Christophe Antoine, Jérôme Honnorat, Jafar Kafaie, Liberty François‐Moutal, Aubin Moutal   +12 more
wiley   +1 more source

Characterization of the Surfaces and Near-Surface Atmospheres of Ganymede, Europa and Callisto by JUICE. [PDF]

Space Sci Rev
Tosi F, Roatsch T, Galli A, Hauber E, Lucchetti A, Molyneux P, Stephan K, Achilleos N, Bovolo F, Carter J, Cavalié T, Cimò G, D'Aversa E, Gwinner K, Hartogh P, Huybrighs H, Langevin Y, Lellouch E, Migliorini A, Palumbo P, Piccioni G, Plaut JJ, Postberg F, Poulet F, Retherford K, Rezac L, Roth L, Solomonidou A, Tobie G, Tortora P, Tubiana C, Wagner R, Wirström E, Wurz P, Zambon F, Zannoni M, Barabash S, Bruzzone L, Dougherty M, Gladstone R, Gurvits LI, Hussmann H, Iess L, Wahlund JE, Witasse O, Vallat C, Lorente R.   +46 more
europepmc   +1 more source