Results 31 to 40 of about 175,990 (269)
Insights and challenges on animal models for progressive multiple sclerosis
Journal of NeuroinflammationProgressive multiple sclerosis (PMS) remains a major clinical challenge due to its complex pathophysiology and limited therapeutic options. While disease-modifying therapies have significantly improved prognosis for relapsing forms of multiple sclerosis (
Isabella F. Nalepa +5 more
doaj +1 more source
Design of a New Method for Detection of Occupancy in the Smart Home Using an FBG Sensor
Sensors, 2020 This article introduces a new way of using a fibre Bragg grating (FBG) sensor for detecting the presence and number of occupants in the monitored space in a smart home (SH).
Jan Vanus +3 more
doaj +1 more source
Site-Specific Glycosylation of Recombinant Viral Glycoproteins Produced in Nicotiana benthamiana
Frontiers in Plant Science, 2021 There is an urgent need to establish large scale biopharmaceutical manufacturing capacity in Africa where the infrastructure for biologics production is severely limited. Molecular farming, whereby pharmaceuticals are produced in plants, offers a cheaper
Emmanuel Margolin +18 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
PET technology for drug development in psychiatry
Neuropsychopharmacology Reports, 2020 Positron emission tomography (PET) is a non‐invasive imaging method to measure the molecule in vivo. PET imaging can evaluate the central nervous system drugs as target engagement in the human brain. For antipsychotic drugs, adequate dopamine D2 receptor
Ryosuke Arakawa +2 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
The influence of movement on the occupancy–density relationship at small spatial scales
Ecosphere, 2019 The global decline of large carnivores demands effective and efficient methods to monitor population status, particularly using non‐invasive methods. Density is among the most useful metrics of population status because it is directly comparable across ...
Matthew S. Rogan +8 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Survey methods for the purple martin in California
California Fish and Wildlife JournalThe purple martin (Progne subis) has declined substantially in numbers and geographic range since the 1980s. Surveys and monitoring are needed to better understand the status of the species, in order to set conservation priorities and direct actions ...
Daniel Airola
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source