Results 61 to 70 of about 248,040 (264)

SIRT6‐Mediated Deacetylation of ATF3 Promotes Silica‐Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α

Advanced Science, EarlyView.
SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng, Wenxia Bu, Fengxu Wang, Yueyuan Jin, Rongzhu Liu, Rui Zhao, Xuehai Wang, Mengna Jiang, Jinping Shen, Xinhang Cheng, Zuming Chen, Li Zhu, Jinlong Li, Zhenzhong Ge, Shichen Miao, Haotian Xu, Xiaoyu Zhou, Dongming Wang, Xinyuan Zhao   +18 more
wiley   +1 more source

Effect of linezolid combined with N-acetylcysteine on lung function, blood gas and inflammation in patients with severe pneumonia

Pakistan Journal of Pharmaceutical Sciences
Background: Severe pneumonia is a serious lung disease. The continuous and regular administration of antibiotics is currently used for severe pneumonia. However, the single antibiotic may enhance the drug resistance and the overall efficacy is not ideal.
Xiaoyan Bai, Yao Luo, Jiajia Huang, Guangfeng Liu   +3 more
doaj   +1 more source

Occupational lung disease

Journal of the Royal College of Physicians of Edinburgh, 2013
Occupational medicine represents the interface between work and health. As such, its breadth encompasses issues of clinical medicine, epidemiology, occupational hygiene, toxicology, ethics, and the law. The diagnosis of an occupational lung disease has implications not only for the health of the worker, but also in some circumstances for the health of ...
P A, Reid, P T, Reid
openaire   +2 more sources

Long‐Term Ambient Benzene Exposure and Brain Disorders Among Urban Adults: Effect Modification by Genetic Susceptibility and Potential Mediation by Plasma Proteins

Advanced Science, EarlyView.
Low‐level ambient benzene exposure is associated with increased risks of multiple brain disorders in urban adults. Genetic susceptibility modifies these associations, while plasma proteomics points to potential biological pathways linking benzene exposure to adverse brain health.
Jianhui Guo, Xia Zhong, Petros Koutrakis, Carolina L. Zilli Vieira, Feifei Si, Yaqi Wang, Xinyao Lian, Yi Fan, Zhaokun Wang, Shaodan Huang, Jing Li   +10 more
wiley   +1 more source

Visual indicator for the detection of methylmercury in blood: A critical biomarker for dietary exposure assessment

Ecotoxicology and Environmental Safety
Methylmercury (MeHg), a significant dietary exposure biomarker, poses a substantial threat to public health, primarily due to the consumption of aquatic foods.
Yan Guo, Bing-chan Ma, Wen-qi Zhang, Bo-xin Li, Jia-ming Ou, Fen Liu, Chang-ye Hui   +6 more
doaj   +1 more source

KRT14 Drives Basal Muscle‐Invasive Bladder Cancer Progression and Lung Metastasis by Directly Binding to and Stabilizing IGF2BP1

Advanced Science, EarlyView.
We identified a Krt14+ Igf2bp1+ bladder cancer population linked to EMT. Mechanistically, KRT14 stabilizes and transports IGF2BP1 to invasive protrusions, initiating a positive feedback loop that drives metastasis and poor outcomes. ABSTRACT Basal‐type muscle‐invasive bladder cancer (BMIBC) is characterized by aggressive metastasis and poor prognosis ...
Shirui Huang, Zhihan Zhou, Qipeng Xie, Zheng Wang, Lijiong He, Yutong Liu, Lijuan Huang, Liuxian Ye, Limeng Hu, Baokun Li, Yang Wang, Xiaohui Hua, Xuelei Liu, Yunping Zhao, Jingxia Li, Jinfei Chen, Guiying Wang, Xian Shen, Wei Chen, Chuanshu Huang   +19 more
wiley   +1 more source

Clinical characteristics and early admission predictors of in-hospital death in acute paraquat poisoning: a retrospective cohort study of 128 patients

Frontiers in Medicine
BackgroundAcute paraquat (PQ) poisoning is associated with high mortality and rapid multi-organ injury. Early risk stratification is particularly important when plasma or urine PQ concentrations are unavailable.
Yuquan Chen, Meiwen Xie, Yifan Ye, Yuqiang Lin, Zhiqian Yang, Zhi Wang   +5 more
doaj   +1 more source

Gender-related aspects in occupational allergies – Secondary publication and update

World Allergy Organization Journal, 2017
For years occupational allergies have been among the most frequently recorded occupational diseases, and both the skin as well as the respiratory tract may be affected. An estimated 9 to 15% of adult asthma is (partially) caused by work-related exposure.
Monika Raulf, Thomas Brüning, Erika Jensen-Jarolim, Vera van Kampen   +3 more
doaj   +1 more source

Harnessing Large‐Scale Multi‐Omics Data for Risk Prediction and Deep Phenotyping of Valvular Heart Diseases in the General Population

Advanced Science, EarlyView.
Large‐scale UK Biobank analyses identify clinical and proteomic signatures for early prediction of valvular heart disease and its subtypes. Proteins add predictive value for VHD, AVS, and MVR, with outcome‐specific compact panels showing translational potential. Multi‐layer evidence highlights matrix remodeling, protease regulation, immune inflammation,
Zhihao Jiang, Yang Liu, Mingyu Song, Ning Chen, Canqing Yu, Jun Lv, Eric Yuk Fai Wan, Lu Qi, Liming Li, Dianjianyi Sun, Bang Zheng   +10 more
wiley   +1 more source

Incidence analysis of occupational respiratory diseases in Türkiye: a cross-sectional legal registry-based study from 2013 to 2023

BMC Public Health
Attending to the scarcity of research on the burden of occupational respiratory diseases in Türkiye, in the present registry-based epidemiological study, we investigated the incidence of occupational respiratory diseases in the country.
Ömür Güngör, Özge Özata Güngör
doaj   +1 more source