Results 31 to 40 of about 5,099,420 (368)

CARD9 Conveys Pancreatic Islet Sympathetic Nervous β2 Signals to Reshape Macrophage Creatine Metabolism in Type 1 Diabetes

Advanced Science, EarlyView.
This study identifies CARD9 as a key mediator linking sympathetic β2‐adrenergic receptor signaling to macrophage creatine metabolism, inflammatory polarization, and neuronal integrity. Loss of β2‐AR‐PKA‐CREB1‐CARD9 signaling in macrophages reduces creatine uptake, promotes pro‐inflammatory macrophage activation, and drives sympathetic axon ferroptosis.
Huimin Yuan, Senlin Li, Shuai Liu, Hong Zhou, Yue Xu, Wenhui Li, Mengxuan Wang, Mengheng Wang, Mengzhu Zheng, Wenxi Shi, Xin Li, Yiting Feng, Ming Xiang   +12 more
wiley   +1 more source

Effects of telerehabilitation in occupational therapy practice: A systematic review

Hong Kong Journal of Occupational Therapy, 2019
Objective/background This study aimed to review the current evidence on the application of telerehabilitation in occupational therapy practice and its clinical outcomes over the last 10 years.
Goris Hung Kn, K. Fong
semanticscholar   +1 more source

Interior Decorative VOCs Elevate T Cell‐Mediated Obstructive Lung Disease Risks via Osteogenesis‐Driven Lymphoid‐Biased Hematopoiesis

Advanced Science, EarlyView.
This study utilizes a whole‐body inhalation model to reveal that interior decorative VOCs exposure persistently elevates alveolar T cells. This increase is attributed to lymphoid‐biased hematopoiesis in the bone marrow, which is further driven by IL‐6/IL‐17A‐mediated osteogenic differentiation.
Hongyan Yu, Jingxu Zhang, Qingping Liu, Duxing Li, Ruonan Pan, Gan Miao, Yidi Chen, Zhe Kou, Guangbo Qu, Rong Zhang, Xiaoting Jin, Yuxin Zheng   +11 more
wiley   +1 more source

Boron Nitride Nanomaterials Trigger Immunomodulatory Effects in Human Broncho‐Epithelial Cells by Modulating Eicosanoid Lipid Signaling

Advanced Science, EarlyView.
This study demonstrates that BNNT exposure disrupts lipid homeostasis in bronchial epithelial cell cultures and activates eicosanoid lipid biosynthesis, producing inflammatory lipid mediators like leukotrienes. These effects are more pronounced in asthmatic cell cultures compared to healthy ones.
Govind Gupta, Jonas Bossart, Sènan Mickael D'Almeida, Luis Augusto Visani de Luna, Christoph Schwärzler, Tingting Fu, Vanesa Ayala‐Nunez, Alexander Gogos, Marija Buljan, Vera M Kissling, Emmanuel Flahaut, Miguel Garcia, Cyrill Bussy, Peter Wick, Tina Buerki‐Thurnherr   +14 more
wiley   +1 more source

Hospitalized Older Patients’ Readiness to Use mHealth Mobility Apps

AGING MEDICINE, EarlyView.
Hospitalized older adults prefer to remain active (81%) and are willing to use mHealth apps (55%) to support mobility. Our study highlights the potential of digital tools to improve engagement and reduce hospital‐associated disability. Most participants were comfortable using smartphones, presenting a promising avenue for implementing mHealth solutions.
Trevor Denton, Shuo Tian, Sachita Shrestha, Liana Marquis, Anupama Goyal, Stephanie Parks Taylor, David Paje   +6 more
wiley   +1 more source

Outcomes of Resected Cases of Pancreatic Ductal Adenocarcinoma Patients With Unexpected Postoperative Uncovering Noncurative Factors: A Multicenter Retrospective Study

Annals of Gastroenterological Surgery, EarlyView.
We aimed to refine treatment strategies for resected cases of pancreatic ductal adenocarcinoma in patients with unexpectedly uncovered postoperative noncurative factors. Cases with unexpected postoperative uncovering noncurative factors had significantly poorer prognoses than those without such factors.
Hiroto Matsui, Naoki Ikenaga, Masafumi Nakamura, Takaaki Tatsuguchi, Shingo Kozono, Hirohisa Okabe, Hiromitsu Hayashi, Tomohiko Adachi, Susumu Eguchi, Kazuaki Hashimoto, Toru Hisaka, Takao Ide, Hirokazu Noshiro, Teijiro Hirashita, Atsushi Miyoshi, Atsushi Nanashima, Masatoshi Kajiwara, Tomoharu Yoshizumi, Yasuhisa Mori, Hiroaki Nagano, Kyushu Study Group of Treatment for Pancreatobilliary Cancer   +20 more
wiley   +1 more source

Parent engagement and disengagement in paediatric settings: an occupational therapy perspective

Disability and Rehabilitation, 2019
Purpose: This study aimed to understand parent engagement and disengagement in the delivery of occupational therapy to their children. Methods: This study used a qualitative interpretive description methodology.
Rachel G D'Arrigo, J. Copley, A. Poulsen, J. Ziviani   +3 more
semanticscholar   +1 more source

Skin‐Conformal Myography for Real‐Time Hand Tracking Using a Laser‐Induced Graphene Strain Sensor Array

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
A skin‐conformal wearable device based on laser‐induced graphene is developed for continuous strain measurement across the circumference of the forearm for gesture recognition and hand‐tracking applications. Post material optimization, the strain sensor array is integrated with a wearable wireless readout circuit for real‐time control of a robotic arm,
Vinay Kammarchedu, Monther AlSiyabi, Aida Ebrahimi   +2 more
wiley   +1 more source

Clinical Presentation of the Longest Reported Living Individual With Bent Bone Dysplasia—FGFR2‐Related

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The FGFR2 gene, encoding the FGFR2 protein, plays a crucial role in embryonic cell development, particularly in bone tissue. Bent Bone Dysplasia (BBD), FGFR2‐related (MIM# 614592), is a rare severe skeletal dysplasia characterized by craniofacial differences, reduced bone mineral density, and bowed long bones.
Cheyenne Bates, Pardeep Gill, Matthew Choi, Frances Mahon, Blake Yarascavitch, Audrey Lim, Resham Ejaz   +6 more
wiley   +1 more source

Occupational challenges in a digital society: A discussion inspiring occupational therapy to cross thresholds and embrace possibilities

Scandinavian Journal of Occupational Therapy, 2019
The digital transformation of society and the increased need for digital competence implies extensive changes in peoples’ everyday lives and occupations.
M. Larsson-Lund, A. Nyman
semanticscholar   +1 more source