Results 51 to 60 of about 824,278 (263)

Occurrence State and Extraction of Lithium from Jinyinshan Clay-Type Lithium Deposit, Southern Hubei: Novel Blank Roasting–Acid Leaching Processes

Applied Sciences
Addressing the technological bottlenecks in the efficient utilization of clay-type Li deposits in China, this study systematically investigates Li occurrence states and develops clean extraction processes using the Jinyinshan clay-type Li deposit in ...
Hao Zhang, Peng Li, Wensheng Zhang, Jiankang Li, Zhenyu Chen, Jin Yin, Yong Fang, Shuang Liu, Jian Kang, Dan Zhu   +9 more
doaj   +1 more source

Multiomics analysis of metabolic heterogeneity in cervical cancer cell lines with or without HPV

Frontiers in Oncology, 2023
Metabolomics analysis revealed the metabolic heterogeneity of cervical cancer (CC) cell lines C33A and CaSki, and their molecular mechanisms were explored.
Xu Liu, Xu Liu, Xu Liu, Yaqi Zhu, Sheng Huang, Sheng Huang, Tingyu Shi, Tingyu Shi, Tanghua Li, Tanghua Li, Yanan Lan, Yanan Lan, Xiaojian Cao, Yingtao Wu, Jinya Ding, Xiaohua Chen, Xiaohua Chen, Xiaohua Chen   +17 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Comparative Study on REE Occurrence Mode in Ion- adsorption Type REE Deposits from Changting, Fujian, and Northern Myanmar

Kuangchan zonghe liyong
Taking the samples of granite weathering crust ion adsorption rare earth deposits in Changting area of Nanling, Fujian and a place in northern Myanmar as the research objects, the geochemical characteristics, mineral characteristics, composition and ...
Xiaoyu LI, Wenliang XIONG, Lijun ZHANG, Da CHEN, Zhimin ZHU   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

A Review of a Preliminary Quantitative Study and Genetic Analysis for Rare Earth Elements of Ionic Adsorption State in Phosphate Ore Deposit in Zhijin, Guizhou Province

Yankuang ceshi, 2014
Recent studies on rare earth elements (REEs) for the Phosphate Deposit in Zhijin, Guizhou show that the occurrence state of REEs is dominated by isomorphism on the basis of the positive correlation between ∑REEs content and phosphorus content.
DUAN Kai-bo, WANG Deng-hong, XIONG Xian-xiao, LIAN Wei, GAO Peng, WANG Ying-lin, ZHANG Yang   +6 more
doaj   +2 more sources

Molecular Dynamics Simulation Study on the Occurrence of Shale Oil in Hybrid Nanopores

Molecules
The molecular dynamics simulation was used to simulate the influence of the composite wall stacking effect on shale oil occurrence. The kerogen-illite heterogeneous wall pore model was established to study the effects of temperature, pore size, and wall ...
Yujia Fang, Zhongxiao Li, Erlong Yang, Mingyu Sha, Shuling Song   +4 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source