Results 201 to 210 of about 203,616 (288)

Targeting mitochondrial bioenergetics: the "Achilles' heel" of Leishmania. [PDF]

Parasit Vectors
Sarkar D, De Sarkar S, Goswami D, Chatterjee M.   +3 more
europepmc   +1 more source

Isolation of Extracellular Vesicles From Mouse Brown Adipose Tissue Secretome Using Size‐Exclusion Chromatography

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
Schematic depicting isolation of extracellular vesicles (EVs) from brown adipose tissue (BAT) and their confirmation and quantification by proteomics analysis. The graphical abstract was created using BioRender.com. ABSTRACT Brown adipose tissue (BAT) is a thermogenic tissue that functions in an endocrine, paracrine, and autocrine manner.
Parth Pardeshi, Daniel Velasquez‐Ramirez, Juan David Salazar‐Gil, Tatiana Cuellar‐Gaviria, Lisa A. Baer, Natalia Higuita‐Castro, Kristin I. Stanford   +6 more
wiley   +1 more source

Integrated framework utilizing scene text detection and recognition techniques for enhancing point of interest extraction from name boards in all Indic languages. [PDF]

Sci Rep
Kashyap AK, Upadhya M, Panwar VS, Chandrakar V.   +3 more
europepmc   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, Volume 20, Issue 5, Page 1161-1184, May 2026.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Correction: Polo-like kinase 3 inhibits glucose metabolism in colorectal cancer by targeting HSP90/STAT3/HK2 signaling. [PDF]

J Exp Clin Cancer Res
Ou B, Sun H, Zhao J, Xu Z, Liu Y, Feng H, Peng Z.   +6 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, Volume 16, Issue 5, Page 885-905, May 2026.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

1,1-Diethoxyethane enhances aerobic respiration in human mitochondria via activation of AMP-activated protein kinase. [PDF]

Commun Biol
Nguyen Huu T, Duong Thanh H, Kim MK, Kumar Sah D, Trinh VH, Yoon HJ, Choi JM, Lee GH, Kim SY, Lee SR.   +9 more
europepmc   +1 more source

Bioinspired, Mitochondria‐Targeted Single‐Atom Nanozyme Enhances Bone Regeneration by Reprogramming Stem Cell Energy Metabolism​

Advanced Materials, Volume 38, Issue 26, 8 May 2026.
A bioinspired nanozyme—triphenylphosphonium (TPP)‐dendritic mesoporous silica nanoparticle (DMSN)‐Fe/Cu—mimics mitochondrial complex IV and targets mitochondria to regulate cellular energy metabolism. This approach markedly boosts bone regeneration in vivo, as demonstrated by enhanced bone volume and mineral density in critical‐sized bone defects rat ...
Yuwen Wang, Xinzhi Liang, Tiandi Xiong, Zheng Zhong, Ning Zhang, Boguang Yang, Dong Li, Qiongjiao Zeng, Xian Chen, Yiting Lei, Shangsi Chen, Chao Zheng, Liu Yang, Wei Huang, Rocky S. Tuan, Denghui Xie, Zhong Alan Li   +16 more
wiley   +1 more source

Discovery of Niclosamide Analogs with Potent Mitochondrial Uncoupling Activity and Reduced Mitochondrial Inhibition-Associated Toxicity. [PDF]

ACS Med Chem Lett
Jiang H, Macorano A, Xing E, Jedoui M, Mohammed S, Lee V, Cheng J, McDonough L, Cheng X, Ye J, Li PK.   +10 more
europepmc   +1 more source

Microglia Mitochondria Support Neuronal Maturation via Metabolic and Transcriptional Reprogramming in Human 3D In Vitro Brain Model

Advanced Science, Volume 13, Issue 25, 4 May 2026.
xx xx. ABSTRACT Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by disrupted neuronal circuit maturation. Emerging evidence implicates microglial function and mitochondrial regulation as contributors to ASD‐associated biology, yet the mechanisms linking these processes to neuronal development remain poorly defined ...
Sydney P. Sterben, Charitha C. Anamala, Sahan B. S. Kansakar, Vaishnavi Koduri, Volha Liaudanskaya   +4 more
wiley   +1 more source