Results 71 to 80 of about 203,616 (288)

Real-World Clinical and Economic Outcomes Among Persons With Multiple Sclerosis Initiating First- Versus Second- or Later-Line Treatment With Ocrelizumab

Neurology and Therapy, 2023
Introduction Prior research has demonstrated that early treatment with high-efficacy disease-modifying therapies (DMTs), including ocrelizumab (OCR), can reduce relapses and delay disease progression among persons with multiple sclerosis (pwMS) compared ...
Caroline K. Geiger, Danny Sheinson, Tu My To, David Jones, Nicole G. Bonine   +4 more
doaj   +1 more source

Detachment‐Induced FAK‐STAT3‐NNMT Inhibits CTCs Anoikis to Promote Breast Cancer Metastasis by Enhancing Fatty Acid Oxidation

Advanced Science, EarlyView.
The FAK‐STAT3‐NNMT axis drives anoikis resistance in circulating tumor cells by reprogramming fatty acid oxidation. Targeting this metabolic vulnerability suppresses metastasis, untangling a key mechanism of breast cancer progression and revealing NNMT as a promising therapeutic target.
Qingchao Tong, Yilei Ma, Yuzhen Gao, Lin Zhou, Luping Lou, Qiang Fang, Sining Fang, Ru Zhao, Jin Zeng, Jun Yang, Guoli Li, Xinyou Xie, Yanzhong Wang, Jun Zhang   +13 more
wiley   +1 more source

Semantic Text Segmentation from Synthetic Images of Full-Text Documents

Информатика и автоматизация, 2019
An algorithm (divided into multiple modules) for generating images of full-text documents is presented. These images can be used to train, test, and evaluate models for Optical Character Recognition (OCR).
Lukáš Bureš, Ivan Gruber, Petr Neduchal, Miroslav Hlaváč, Marek Hrúz   +4 more
doaj   +1 more source

Reducing OCR errors by combining two OCR systems [PDF]

, 2010
This paper describes our efforts in building a heritage corpus of Alpine texts. We have already digitized the yearbooks of the Swiss Alpine Club from 1864 until 1982. This corpus poses special challenges since the yearbooks are multilingual and vary in orthography and layout. We discuss methods to improve OCR performance and experiment with combining
Volk, Martin, Marek, T, Sennrich, R
openaire   +2 more sources

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

EFFICACY OF TOPICAL ANAESTHESIA IN REDUCTION OF OCULOCARDIAC REFLEX DURING SQUINT SURGERY

Pakistan Armed Forces Medical Journal, 2020
Objective: To determine the efficacy of Topical Anaesthesiain reduction of oculocardiac reflex incidence and severity in patients undergoing squint surgery under general anaesthesia. Study Design: Quasi-Experimental Study.
Sana Abbas, Omar Zafar, Muhammad Awais, Beenish Abbas, Umer Hayat, Basit Mehmood   +5 more
doaj  

Tetrahedral DNA Nanostructure‐Based Biomimetic Nanovesicles Attenuate Sepsis‐Associated ARDS by Suppressing Glycolysis via the BMAL1/PFKFB3 Axis

Advanced Science, EarlyView.
Upon inhalation, RM@TNT could persist long‐term in the diseased lungs, while undergoing disintegration to release TNT specifically within the ROS‐rich pathological microenvironments of SA‐ARDS. The released TNT was then precisely delivered to AMs via Tuftsin, where it released Nob intracellularly to activate BMAL1 expression, thus inhibiting AM ...
Yunlong Zhang, Bin Li, Zhijin Fan, Yan Yan, Fei Ma, Changting He, Shiping Liu, Mingliang Pan, Zhou Pan, Huijuan Wang, Xinting Fu, Jiamei Wang, Yue Jia, Qin Gu, Duo Jiang, Xueting Liu, Bohua Ren, Qinqin Wang, Yuehua Hei, Han Duan, Yanqiu Wu, Zihui Wei, Liying Zhan, Yuhui Liao   +23 more
wiley   +1 more source

Automatic License Plate Recognition (ALPRON) Using Optical Character Recognition Method

Journal of Applied Informatics and Computing
Manual parking systems are prone to inefficiencies and human error, especially with increasing vehicle density. This study proposes ALPRON, an automatic license plate recognition system using Optical Character Recognition (OCR) to automate motorcycle ...
Purwono Prasetyawan, Muhammad Athallah Cahya Aulia, Nia Saputri Utami, Uri Arta Ramadhani   +3 more
doaj   +1 more source

Automation of PostOCR error correction in the digitization of historical texts [PDF]

Computer Science Journal of Moldova
Processing texts from distant historical periods, especially those handwritten in languages with low computational resources, presents significant challenges. Even if modern methods make it possible to achieve, after laborious machine learning procedures,
Tudor Bumbu , Liudmila Burtseva, Svetlana Cojocaru, Alexandru Colesnicov, Ludmila Malahov   +4 more
doaj   +1 more source

Mitochondrial Enzymes Mimetic Ultrasmall Palladium Nanozymes Prevent Senescence and Neurodegeneration Through Metabolic Reprogramming

Advanced Science, EarlyView.
Simply constructed polyvinylpyrrolidone (PVP) modified palladium nanoparticles (PdP NPs) as cytochrome c oxidase (CcO) and superoxide dismutase (SOD) mimic are promising multifunctional nanoreactors to boost mitochondrial respiration chain function and refine homeostasis via regulation of mitochondrial dynamics and proteostasis sensor UPRmt, which ...
Wenshu Cong, Haiming Jing, Zinan Li, Wenjing Zhang, Nan Zhang, Yingqiu Xie, Shan Gao, Yuanyu Huang, Junyu Ning   +8 more
wiley   +1 more source