Results 231 to 240 of about 2,884,168 (334)

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

Advanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang   +36 more
wiley   +1 more source

PAIR: Evaluating the Limits of Agreement Among Non-Retinal Specialist Using PathFinder Artificial Intelligence Tool for Retinal Disease Referrals: A Prospective Observational Study. [PDF]

Clin Ophthalmol
Fong KCS, Wong WJ, Samsudin A, Ganasan DK, Goh WN, Tai JY, Fong SN, Cheong CYJ, Rajamanickam G, Shunmugam M.   +9 more
europepmc   +1 more source

OCT angiography and visible-light OCT in diabetic retinopathy.

Vision Research, 2017
Peter L. Nesper, Brian T. Soetikno, Hao F. Zhang, A. Fawzi   +3 more
semanticscholar   +1 more source

Single‐Mitochondrion ATP Profiling Directs Discovery of Targetable OXPHOS Dependency in Cancers

Advanced Science, EarlyView.
MitoATP‐nFCM integrates nano‐flow cytometry with fluorogenic probes (ATP/membrane potential) and antibodies to quantify mitochondrial metabolites and protein expression at single‐organelle resolution, exposing oxidative phosphorylation (OXPHOS)‐driven metabolic rewiring in cancers.
Xu Xiao, Cheng Lu, Hao Chen, Jing Zhou, Yunyun Hu, Haonan Di, Guoqiang Su, Xiaomei Yan   +7 more
wiley   +1 more source

Optical coherence tomography-derived coronary vessel wall abnormalities in adults long after Kawasaki disease. [PDF]

PLoS One
Ohashi H, Mitani Y, Terashima M, Sawai T, Sawada H, Hayakawa H, Yodoya N, Dohi K, Kitagawa K, Sakuma H, Hirayama M.   +10 more
europepmc   +1 more source

Clinical Impact of OCT Findings During PCI: The CLI-OPCI II Study.

JACC Cardiovascular Imaging, 2015
F. Prati, E. Romagnoli, F. Burzotta, U. Limbruno, L. Gatto, A. L. La Manna, F. Versaci, V. Marco, L. Di Vito, F. Imola, G. Paoletti, C. Trani, C. Tamburino, L. Tavazzi, G. Mintz   +14 more
semanticscholar   +1 more source

Palmitoylation‐Mediated Ubiquitination of SRPK1 Regulates Ferroptosis in High‐Fat‐Induced Erectile Dysfunction

Advanced Science, EarlyView.
Elevated exogenous palmitic acid promotes the S‐palmitoylation of SRPK1 in endothelial cells, a dynamic process governed by ZDHHC24 and APT1. This post‐translational modification strengthens the interaction between SRPK1 and the E3 ubiquitin ligase MIB1, thereby facilitating the proteasomal degradation of SRPK1.
Xiao‐Hui Tan, Ke‐Fan Li, Yi‐Ming Yuan, Man‐Cheng Xia, Fang‐Zhou Zhao, Hong‐Gang Ying, Zhuo Zhou, Peng‐Chao Gao, Guo‐Qing Xie, Xue‐Song Li, Hui Jiang, Rui‐Li Guan   +11 more
wiley   +1 more source

Label-free assessment of a microfluidic vessel-on-chip model with visible-light optical tomography reveals structural changes in vascular networks.

Lab Chip
Veerman D, Cuartas-Vélez C, Gensheimer T, van Dorp T, van der Meer A, Bosschaart N.   +5 more
europepmc   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Comparison of corneal thickness measured using the new Revo FC optical coherence tomographer and the pentacam Scheimpflug-based imaging system. [PDF]

BMC Ophthalmol
Tubis J, Zajączkowska Z, Kanclerz P.
europepmc   +1 more source