Results 131 to 140 of about 35,214 (239)
From Payload‐First Toward Dual‐Mechanism Antibody–Drug Conjugates
Advanced Materials, Volume 38, Issue 49, 1 September 2026.Conjugation converts potent antibodies into underexposed carriers. This perspective defines the antibody exposure deficit and maps a mechanism‐first design space from payload‐first to antibody‐first ADC architectures, integrating DAR, linker chemistry, and Fc engineering to guide rational design of constructs that balance targeted cytotoxicity with ...
Xavier Pivot +3 more
wiley +1 more source
OCTA-Based Biomarker Characterization in nAMD
2025 IEEE 6th International Conference on Image Processing, Applications and Systems (IPAS)We aim to enhance ophthalmologists' decision-making when diagnosing the Neovascular Age-Related Macular Degeneration (nAMD). We developed three tools to analyze Optical Coherence Tomography Angiography images: (1) extracting biomarkers such as mCNV area and vessel density using image processing; (2) generating a 3D visualization of the ...
Maria Simona Tivadar +3 more
openaire +3 more sources
Advanced Science, Volume 13, Issue 50, 7 September 2026.Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang +19 more
wiley +1 more source
Secondary choroidal neovascular membrane in a case of torpedo maculopathy
Indian Journal of Ophthalmology, 2020 Manoj Soman +3 more
doaj +1 more source
Distinct ocular microvascular alterations in Alzheimer's disease and cerebral small vessel disease
Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.Abstract INTRODUCTION While both Alzheimer's disease (AD) and cerebral small vessel disease (CSVD) involve vascular dysfunction, the ocular microvascular differences between them remain largely underinvestigated. METHODS This cross‐sectional study included 650 participants (149 AD, 276 CSVD, and 225 cognitively unimpaired individuals).
Ziyi Zhang +15 more
wiley +1 more source
A Review of Artificial Intelligence in Ophthalmology: Key Aspects, Challenges, and Future Directions
Eye &ENT Research, Volume 3, Issue 3, Page 125-154, September 2026.ABSTRACT Artificial intelligence (AI) is increasingly reshaping ophthalmology because the specialty depends heavily on structured imaging, quantitative measurements, and repeatable diagnostic workflows. This review provides a clinically grounded and translationally oriented synthesis of AI in ophthalmology, covering methodological foundations ...
Partha Pratim Ray
wiley +1 more source
Advances in Organic Aggregates for Biomedical Phototheranostics
MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.Organic aggregates offer aggregation‐regulated photophysical properties for biomedical phototheranostics, enabling enhanced fluorescence, stabilized room‐temperature phosphorescence, and efficient photoacoustic/photothermal responses. This review highlights molecular design strategies, excited‐state energy modulation, biomedical applications, and ...
Bowen Fu, Yayun Peng, Ting Cai
wiley +1 more source
Indian Journal of OphthalmologyPurpose: To compare the diagnostic ability of macular ganglion cell inner plexiform layer (mGCIPL) and peripapillary retinal nerve fiber layer (pRNFL) thickness on optical coherence tomography (OCT) and macular and peripapillary perfusion changes using ...
Dewang Angmo +6 more
doaj +1 more source
Compound Heterozygous PCDH15 Variants Associated With Cone‐Rod Dystrophy in a Chinese Pedigree
Molecular Genetics &Genomic Medicine, Volume 14, Issue 9, September 2026.This study represents the first report suggesting a genotype–phenotype relationship between PCDH15 genetic variants and isolated retinal manifestations absent auditory impairment or syndromic features, thereby providing preliminary evidence that may broaden the mutational spectrum associated with this gene.
Lei Zhang +7 more
wiley +1 more source
Diabetes, Obesity and Metabolism, Volume 28, Issue 9, Page 7864-7874, September 2026.ABSTRACT Aims To evaluate the association between continuous glucose monitoring (CGM)‐derived glycaemic variability indicators and early microvascular changes of the retina and choroid in nondiabetic individuals. Materials and Methods Community‐based individuals at high risk for type 2 diabetes (T2DM) underwent detailed assessments including oral ...
Yan Jiang +15 more
wiley +1 more source