Results 51 to 60 of about 643,628 (282)

N4‐acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

Advanced Science, EarlyView.
This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley   +1 more source

The Chicago Counter-Revolution and the Sociology of Economic Knowledge [PDF]

, 2000
This chapter is concerned with the internal phenomenon. One model that can be invoked to explain this internal phenomenon is the classical process whereby evidence is patiently accumulated until the weight of the argument favours one side or another ...
Leeson, Robert
core   +3 more sources

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

Reionization and Cosmic Dawn: theory and simulations

, 2017
We highlight recent progress in the sophistication and diversification of cosmic dawn and reionization simulations. The application of these modeling tools to current observations has allowed us narrow down the timing of reionization, which we now know ...
Mesinger, Andrei
core   +1 more source

Intelligent Soft Opto‐Magnetic Robot for Minimally Invasive Interventional Therapy

Advanced Science, EarlyView.
An intelligent soft opto‐magnetic (iSOM) robot is developed that integrates remote magnetic actuation, skin‐mimic tactile perception, and photothermal ablation in a near‐millimeter‐scale design. It enables precise intraluminal navigation and localized ablation while providing real‐time optical feedback to support safe and accurate minimally invasive ...
Jingjing Guo, Xiaoyan Guo, Jian Wei, Miaowen Jiang, Qifa Su, Xian Xia, Zhuozhou Li, Rong Cai, Jianguo Ma, Bo Fu, Ming Li, Jing Zhong, Lijun Xu, Xunming Ji   +13 more
wiley   +1 more source

Morpheme-Grammar Dictionary of Russian Verbs as a Means of Forming Intuitive Knowledge of the Language

Polylinguality and Transcultural Practices
The study describes the principles of designing a morpheme-grammar dictionary of Russian verbs within the framework of systemic linguistics. As a working hypothesis for the creation of the dictionary the concept of G.P.
Tatiana L. Liakhnovitch, Tatiana V. Vashchekina   +1 more
doaj   +1 more source

Synergistic Activation of Immunogenic Cell Death and the cGAS–STING Pathway by Engineered Zinc/Manganese‐Based Metal–Organic Framework Nanoplatforms for Colon Cancer Immunotherapy

Advanced Science, EarlyView.
A zinc/manganese (Zn/Mn)‐based metal‐organic framework (MOF) loaded with the STING agonist c‐di‐AMP diammonium (denoted AMP@Zn/Mn‐MOF) was developed to synergistically activate the cGAS‐STING pathway and induce immunogenic cell death. This nanoplatform reprograms the immunosuppressive tumor microenvironment, significantly enhancing anti‐PD‐L1 ...
Bingzi Zhu, Xiaodong Chen, Chang Xu, Xuehua Qian, Binglong Bai, Ji Lin, Wenhai Deng, Xiang Wang, Yuekai Cui, Shengsheng Zhao, Zuoliang Xie, Tao You, Yingpeng Huang, Xian Shen, Xufeng Lu, Weijian Sun   +15 more
wiley   +1 more source

The Intelligentsia and the October Revolution

RUS (São Paulo), 2017
This article examines the attitude of the “democratic,” left-leaning intelligentsia to the revolutions of 1917. It documents and analyzes the latter’s growing alienation from the popular classes, the workers and peasants, over the course of 1917.
David Mandel
doaj   +1 more source

Bonbons and Bolsheviks: The Stigmatization of Chocolate in Revolutionary Russia [PDF]

, 2018
This essay examines how and why how the official Party attitude toward chocolate changed rather dramatically during the first two decades of Communist rule.
LeBlanc, Ronald D.
core   +1 more source

English funding of the Scottish armies in England and Ireland 1640-1648 [PDF]

, 2009
The rebellion against Charles I's authority that began in Edinburgh in 1637 involved the Scots in successive invasions of England and armed intervention in Ireland. Historians have almost universally taken a negative view of Scottish involvement in these
Stewart, Laura A.M.
core   +1 more source