Results 131 to 140 of about 61,360 (227)

TRPV4 controls circadian and pathological ocular hypertension. [PDF]

J Physiol
Redmon SN, Lakk M, Tseng YT, Rudzitis CN, Searle JE, Ahmed F, Unser AM, Borrás T, Torrejon K, Križaj D.   +9 more
europepmc   +1 more source

Short-term ocular tolerability of dorzolamide 2% and brinzolamide 1% vs placebo in primary open-angle glaucoma and ocular hypertension subjects [PDF]

, 2004
William C. Stewart, Douglas G. Day, Jeanette A. Stewart, Keri T Holmes, Jessica N. Jenkins   +4 more
openalex   +1 more source

Deuteration of Six‐Membered N‐Heteroarenes: Chemistry and Applications

Chemistry – A European Journal, EarlyView.
Deuterated six‐membered N‐Heteroarenes (6NHetAr) are finding utility in an increasing repertoire of applications. Our paper comprehensively reviews synthetic approaches that have been reported for the deuteration of 6NHetAr and their fused counterparts while providing an overview of established and emerging applications for these materials.
Liju Raju, Davide Benedetto Tiz, Adrian Iles, Janez Košmrlj, Ross D. Jansen‐van Vuuren   +4 more
wiley   +1 more source

Clinical characteristics and risk factors of ocular hypertension: a case-control study. [PDF]

BMC Ophthalmol
Hu F, Luo L, Yang H, Liu T, Yu L.
europepmc   +1 more source

Retinal Ganglion Cell Loss in a Rat Ocular Hypertension Model Is Sectorial and Involves Early Optic Nerve Axon Loss

, 2010
Ileana Soto, Mary Ellen Pease, Janice L. Son, Xiaohai Shi, Harry A. Quigley, Nicholas Marsh‐Armstrong   +5 more
openalex   +2 more sources

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Ascending Doses and Dose Titration of Bexicaserin in Healthy Participants in a Randomized, Double‐Blind, Placebo‐Controlled Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Bexicaserin (LP352) is a selective superagonist of the 5‐hydroxytryptamine 2C (5‐HT2C) receptor currently in development for the treatment of seizures that arise from developmental and epileptic encephalopathies. This phase 1, double‐blind, placebo‐controlled multiple ascending dose (MAD) study assessed the safety, tolerability, and ...
Jonathan Williams, Rosa Chan, Chad Orevillo, Gale O'Connell, Dewey McLin, Shikha Polega, Nuggehally R. Srinivas, Randall Kaye   +7 more
wiley   +1 more source

Characterization of Ocular Sonography Findings and their Relationship to Clinical Features from a South Indian Cohort of Idiopathic Intracranial Hypertension

K.Veera Kishore, Ameya Patwardhan, HR Aravinda, Veerendrakumar Mustare, Subasree Ramakrishnan   +4 more
openalex   +1 more source

Evolving Real‐World Data and Evidence Use for New Drugs and Regenerative Medical Products Approvals in Japan—An Analysis of the 6‐Year Trend

Clinical Pharmacology &Therapeutics, EarlyView.
Several regulatory initiatives have been made to clarify the acceptability and requirements of real‐world data and real‐world evidence (RWD/E) for the benefit/risk assessment of new medical products in Japan. The objectives of this review were to characterize the use of RWD/E in regulatory applications of new medical products and to describe the ...
Suguru Okami, Kako Shimotsumagari, Yasunari Sadatsuki   +2 more
wiley   +1 more source

Ocular hypertension.

Indian Journal of Ophthalmology, 2004
Gopal KS
doaj  

Primary angle-closure eyes with ocular hypertension show preperimetric ganglion cell complex abnormalities. [PDF]

Indian J Ophthalmol
Zalak S, Ramanjit S, Swarnali SR, Samiksha C, Jasleen D.   +4 more
europepmc   +1 more source