Results 11 to 20 of about 1,264,680 (377)

Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

Investigative Ophthalmology and Visual Science, 2022
Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure.
Colleen M. McDowell, K. Kizhatil, M. Elliott, D. Overby, Joseph van Batenburg-Sherwood, J. Millar, M. Kuehn, G. Zode, T. Acott, Michael G. Anderson, S. Bhattacharya, Jacques A. Bertrand, Terete Borrás, Diane E. Bovenkamp, Lin Cheng, J. Danias, Michael L. De Ieso, Yiqin Du, Jennifer A. Faralli, R. Fuchshofer, Preethi S. Ganapathy, H. Gong, S. Herberg, Humberto Hernandez, P. Humphries, S. John, P. Kaufman, Kate E. Keller, M. Kelley, R. Kelly, D. Križaj, Ajay Kumar, B. Leonard, R. Lieberman, P. Liton, Yutao Liu, Katy C. Liu, Navita N. Lopez, Weiming Mao, T. Mavlyutov, Fiona S. McDonnell, G. McLellan, Philip Mzyk, Andrews Nartey, L. Pasquale, Gaurang C. Patel, P. Pattabiraman, D. M. Peters, VijayKrishna Raghunathan, P. Rao, N. Rayana, Urmimala Raychaudhuri, Ester Reina-Torres, R. Ren, D. Rhee, U. R. Chowdhury, J. Samples, E. Samples, N. Sharif, J. Schuman, V. Sheffield, Cooper Stevenson, Avinash Soundararajan, Preeti Subramanian, Chenna Kesavulu Sugali, Yang Sun, C. Toris, Karen Y. Torrejon, A. Vahabikashi, Janice A. Vranka, Ting Wang, C. Willoughby, Chen Xin, Hongmin Yun, Hao F. Zhang, M. Fautsch, E. Tamm, A. Clark, C. Ethier, W. Stamer   +79 more
semanticscholar   +1 more source

Anti-fibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis

eLife, 2021
Glucocorticoids are widely used as an ophthalmic medication. A common, sight-threatening adverse event of glucocorticoid usage is ocular hypertension, caused by dysfunction of the conventional outflow pathway.
Guorong Li, Chanyoung Lee, A Thomas Read, Ke Wang, Jungmin Ha, Megan Kuhn, Iris Navarro, Jenny Cui, Katherine Young, Rahul Gorijavolu, Todd Sulchek, Casey Kopczynski, Sina Farsiu, John Samples, Pratap Challa, C Ross Ethier, W Daniel Stamer   +16 more
doaj   +1 more source

Detecting Glaucoma in the Ocular Hypertension Study Using Deep Learning.

JAMA ophthalmology, 2022
Importance Automated deep learning (DL) analyses of fundus photographs potentially can reduce the cost and improve the efficiency of reading center assessment of end points in clinical trials.
Rui Fan, C. Bowd, Mark Christopher, Nicole Brye, J. Proudfoot, Jasmin Rezapour, A. Belghith, M. Goldbaum, B. Chuter, C. Girkin, M. Fazio, J. Liebmann, R. Weinreb, M. Gordon, M. Kass, D. Kriegman, L. Zangwill   +16 more
semanticscholar   +1 more source

Co-delivery of ripasudil and dexamethasone in trabecular meshwork cells for potential prevention of GC-induced ocular hypertension. [PDF]

Exp Cell Res
Debele TA, Yuan Y, Kao W, Liu CY, Dessie EY, Park YC.   +5 more
europepmc   +2 more sources

Long-Term Intraocular Pressure-Lowering Effects and Adverse Events of Ripasudil in Patients with Glaucoma or Ocular Hypertension over 24 Months

Advances in Therapy, 2022
Glaucoma is a leading cause of irreversible blindness and ripasudil was the first Rho kinase inhibitor approved as antiglaucoma medication. Here we present the final analysis of the ROCK-J study, a large-scale post-marketing surveillance study to ...
H. Tanihara, Takahiko Kakuda, Tetsuro Sano, T. Kanno, Yuji Kurihara   +4 more
semanticscholar   +1 more source

Harnessing the tunable cavity of nanoceria for enhancing Y-27632-mediated alleviation of ocular hypertension

Theranostics, 2021
Background: Y-27632 is a potent ophthalmic drug for the treatment of ocular hypertension, a globally prevalent eye disease. However, the sustained delivery of Y-27632 by a therapeutic carrier to lesion sites located in the inner segments of the eye for ...
Li-Jyuan Luo, D. D. Nguyen, J. Lai
semanticscholar   +1 more source

Airborne particulate matter (PM2.5) triggers ocular hypertension and glaucoma through pyroptosis

Particle and Fibre Toxicology, 2021
Background Particulate matter (PM) is strongly linked to human health and has detrimental effects on the eye. Studies have, however, focused on the ocular surface, with limited research on the impact of PM 2.5 on intraocular pressure (IOP).
Liping Li, Chao Xing, Ji Zhou, Liangliang Niu, B. Luo, M. Song, Jingping Niu, Y. Ruan, Xinghuai Sun, Y. Lei   +9 more
semanticscholar   +1 more source

Assessment of Cumulative Incidence and Severity of Primary Open-Angle Glaucoma Among Participants in the Ocular Hypertension Treatment Study After 20 Years of Follow-up.

JAMA ophthalmology, 2021
Importance Ocular hypertension is an important risk factor for the development of primary open-angle glaucoma (POAG). Data from long-term follow-up can be used to inform the management of patients with ocular hypertension.
M. Kass, Dale K Heuer, Eve J. Higginbotham, Richard K. Parrish, Cheryl L. Khanna, James D. Brandt, J. Soltau, Chris A. Johnson, J. Keltner, J. Huecker, Bradley S. Wilson, Lei Liu, J. P. Miller, H. Quigley, Mae O. Gordon, Steven J. Gedee, Maria Y. Esquiabro, Matthew J. Fabrizio, Charles J. Patorgis, Teresa Long, Paul E. McManus, Chantura Washington, Peter T. Chang, S. Orengo‐Nania, April Leger, S. Mansberger, R. Kinast, Emily P. Jones, Casie Goldman, Allen D. Beck, Anastasios P. Costarides, Donna Leef, N. Imami, D. Darnley-Fisch, David A. Crandall, Melanie Gutkowski, Julianne Hall, Aldo Fantin, Judy Wells, H. Jampel, H. Quigley, Rhonda Miller, Osamah Saeedi, Sachin Kalarn, Anne L. Coleman, Jonathan W. Young, Christine A. Peterson, J. Giaconi, S. Law, Pamela B. Duarte, Sarah K. Wood, Sayoki Moroi, Jesse L. Gilbert, B. Hughes, Aman Shukairy, M. Juzych, Cheryl Milanovic, John M. O'Grady, Linda A. Van Conett, J. Soltau, Judith Mohay-Ambrus, Michelle Bottorff, Cheryl L. Khanna, Jeffrey R. Bennett, Jane L. Sultze, Dharmendra R. Patel, Steven H. Cobb, Pompa Bhattacharjee, J. Liebmann, G A Cioffi, D. Blumberg, L. Al-Aswad, C. D. De Moraes, Marzhan Atakulova, Paul A. Weber, A. K. Sawchyn, Demarcus Williams, G. Bennett, Lindsay C. Bennett, E. Miller-Ellis, Prithvi S. Sankar, Sheri Grand-Drossner, J. Piltz-Seymour, Jane L. Niemczyk, James D. Brandt, Michelle C. Lim, Saranya C. Balasubramaniam, Annie K. Baik, Marisa S. Arnold, R. Weinreb, J. R. Slight, Yvonne Ou, Kathleen A. Lamping, Cheryl Vitelli, Frank S. Ashburn, Karen S. Hardney, Arthur L. Schwartz, Howard S. Weiss, Clete Clark, A. Bhorade, John T. Lind, Eve Adcock, J. Keltner, Chris A. Johnson, Mike A. Smith, K. Plumb, Laura Leming, Bhupinder Dillon, Richard K. Parrish, P. Palmberg, Elizabeth Hodapp, William F Feuer, Elizabeth A. Varner, Eleonore Savatovsky, R. Vandenbroucke, L. Zangwill, Keri Dirkes, Suzanne M. Vega, Maria Hunsicker, James Proudfoot, Dale K Heuer, Eve J. Higginbotham, M. Kass, Debbie A. Dunn, Donald F. Everett, Mae O. Gordon, J. Soltau, Melanie Gutowski, Ellen Fischbach, Karen Clark, P. A. Morris, Melanie Quinn, Sam Pistorius, Bradley S. Wilson, J. Huecker, Leonard W. Haertter, J. P. Miller, Lei Liu   +137 more
semanticscholar   +1 more source

MicroRNA-93/STAT3 signalling pathway mediates retinal microglial activation and protects retinal ganglion cells in an acute ocular hypertension model

Cell Death and Disease, 2021
Glaucoma is a common neurodegenerative disease and a leading cause of irreversible blindness worldwide. Retinal microglia-mediated neuroinflammation is involved in the process of optic nerve damage, but the mechanisms driving this microglial activation ...
Yayi Wang, Shida Chen, Jiawei Wang, Yaoming Liu, Yang Chen, Tao Wen, Xiuli Fang, M. Vidal-Sanz, J. Jonas, Xiulan Zhang   +9 more
semanticscholar   +1 more source

Astragaloside IV Attenuates Ocular Hypertension in a Mouse Model of TGFβ2 Induced Primary Open Angle Glaucoma

International Journal of Molecular Sciences, 2021
Elevated intraocular pressure (IOP) is a major risk factor in developing primary open angle glaucoma (POAG), which is the most common form of glaucoma. Transforming growth factor-beta 2 (TGFβ2) is a pro-fibrotic cytokine that plays an important role in ...
Ramesh B. Kasetti, Prabhavathi Maddineni, Bindu Kodati, Bhavani Nagarajan, Samira F. Yacoub   +4 more
semanticscholar   +1 more source