Results 61 to 70 of about 3,162 (219)

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Nightly Hypoxia Does Not Seem to Lead to Otolith Dysfunction in Patients With Obstructive Sleep Apnea

Ear, Nose & Throat Journal, 2021
Objectives: Obstructive sleep apnea (OSA) is a common sleep disorder, which is associated with recurrent oxygen desaturation during sleep. It has already been shown that nocturnal hypoxia may lead to cochlear dysfunction in patients with OSA.
Richard Birk MD, Miriam Dietz MD, Jörg Ulrich Sommer MD, Boris A. Stuck MD, Karl Hörmann MD, Nicole Rotter MD, Joachim T. Maurer MD, Benedikt Kramer MD, Roland Hülse MD, Angela Schell MD   +9 more
doaj   +1 more source

Skull Vibration Induced Nystagmus Test: Correlations with Semicircular Canal and Otolith Asymmetries

Audiology Research, 2021
Background: To establish in patients with peripheral vestibular disorders relations between skull vibration-induced nystagmus (SVIN) different components (horizontal, vertical, torsional) and the results of different structurally related vestibular tests.
Christol Fabre, Haoyue Tan, Georges Dumas, Ludovic Giraud, Philippe Perrin, Sébastien Schmerber   +5 more
doaj   +1 more source

Video head impulse test can detect brainstem dysfunction in multiple sclerosis [PDF]

, 2017
BACKGROUND: The aim of this study was to investigate the potential role of video head impulse test (vHIT) in the detection of brainstem lesions in patients with multiple sclerosis (MS).
Adamec, Ivan, Crnošija, Luka, Habek, Mario, Krbot Skorić, Magdalena, Pavičić, Tin, Pavlović, Ivan, Ruška, Berislav   +6 more
core   +1 more source

Sono‐Mechanogenetics: Linking Ultrasound Physics With Cellular Mechanobiology

Advanced Science, EarlyView.
Sono‐mechanogenetics links ultrasound physics with cellular mechanotransduction to enable noninvasive control of engineered biological systems. Acoustic forces generate distinct deformation modes that activate intracellular signaling pathways, which can be coupled to synthetic gene circuits to regulate diverse cellular functions, including gene ...
Yunjia Qu, Fan Wei, Chi Woo Yoon, Qifa Zhou, Yingxiao Wang   +4 more
wiley   +1 more source

Deconvolution of the vestibular evoked myogenic potential using the power spectrum of the electromyogram [PDF]

, 2015
BACKGROUND: The vestibular evoked myogenic potential (VEMP) can be modelled reasonably well by convolving two functions: one representing an average motor unit action potential (MUAP), the other representing the temporal modulation of the MUAP rate (rate
Bernd Lütkenhöner
core   +1 more source

Recent advances in the epidemiology and diagnosis of some common vestibular disorders [PDF]

, 2021
There is a rising interest in the diagnosis of the common vestibular disorders in childhood and adulthood. The results from numerous epidemiological investigations prove the socio-medical importance of this pathology.
Milkov, M.
core   +2 more sources

Subjective Visual Vertical Can be an Effective Tool to Evaluate Vestibular Function of Stapedotomy

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective To investigate if the subjective visual vertical/horizontal (SVV/SVH) can be used to evaluate the otolith organ of otosclerosis and stapedotomy. Design A total of 19 patients who were diagnosed with otosclerosis and underwent surgical treatment in our hospital were collected.
Tao Jiang, Juan Zheng, Wen‐Yan Li
wiley   +1 more source

Development of ocular vestibular‐evoked myogenic potentials in small children

The Laryngoscope, 2012
AbstractObjectives/Hypothesis:This study investigated the development of otolithic–ocular reflex in small children (<3 years old) via the ocular vestibular‐evoked myogenic potential (oVEMP) test.Study Design:Prospective study.Methods:Twenty full‐term newborns (group A), 15 children aged 1 to 3 years (group B), and 15 children aged 4 to 13 years ...
Shou-Jen, Wang, Wu-Shiun, Hsieh, Yi-Ho, Young   +2 more
openaire   +2 more sources

Systemic aminoglycosides-induced vestibulotoxicity in humans

, 2017
Objectives: This systematic review aimed to investigate the prevalence and characteristics of vestibular adverse effects of aminoglycoside (AG) therapy in humans and to analyze objective vestibular tests for the detection of AG-induced vestibulotoxicity.
Agrawal, Ahmed, Ahmed, Ahmed, Al-Malky, Ariano, Aust, Barza, Black, Black, Black, Caminero, Carey, Chen, Chiodo, Colebatch, Curthoys, Davis, Deka, Demer, Dobie, Elfving, Esterhai, Eviatar, Farzal, Fausti, Fee, Finitzo-Hieber, Forge, Fujimoto, Gendeh, Gendeh, Geyer, Gibson, Goldberg, Gonçalves, Govaerts, Grohskopf, Guinand, Hain, Halmagyi, Halmagyi, Hauch, Hermann, Hinshaw, Huizing, Ishiyama, Ishiyama, Kahlmeter, Kim, Landis, Lehmann, Leis, Lerner, Li, Liberati, Lindeman, Liu, Lucieer, Lue, Lyford-Pike, Maes, Maes, Matz, McCaslin, Mendel, Minor, Nakashima, Noone, Pedersen, Petersen, Pillers, Poirrier, Prayle, Price, Rizzi, Rogers, Rosengren, Rybak, Schacht, Schatz, Scheenstra, Selimoglu, Selimoğlu, Stavroulaki, Stevenson, Sun, Sun, Tange, Thomas, Tjernström, Tjernström, Tsuji, van de Berg, Vasquez, Venhovens, Ward, Weber, Winkel, Wuyts, Wuyts, Zagólski, Zingler   +102 more
core   +1 more source