Results 101 to 110 of about 11,710 (263)

AZP2006 in Progressive Supranuclear Palsy: Outcomes from a Phase 2a Multicenter, Randomized Trial, and Open‐Label Extension on Safety, Biomarkers, and Disease Progression

Movement Disorders, Volume 40, Issue 12, Page 2700-2709, December 2025.
Abstract Objectives The aim was to evaluate the safety, tolerability, pharmacokinetics, and potential clinical efficacy of AZP2006, an oral pleiotropic drug modulating progranulin levels, in patients with progressive supranuclear palsy (PSP), a rare tauopathy. Methods A randomized, double‐blind, placebo‐controlled, parallel‐group trial was conducted at
Jean‐Christophe Corvol, Mickael Alexandre Obadia, Caroline Moreau, Louise‐Laure Mariani, Jean‐Philippe Brandel, David Devos, Sara Sambin, Nicolas Carrière, Günter Höglinger, Marie Lebouteux, Graziella Mangone, Noelle Callizot, Aurélien Blondel, Olivier Defert, Cecilia Estrella, Artin Karapet, Philippe Verwaerde, Luc Defebvre   +17 more
wiley   +1 more source

Diagnostic Gray Zone: Isolated Left Oculomotor Nerve Palsy in the Setting of Hyperhomocysteinemia, Sphenoid Sinusitis, and Rathke’s Cleft Cyst

International Journal of Medical Students
Rathke’s Cleft Cyst (RCC) is a benign, epithelium-lined cyst arising from remnants of Rathke’s pouch, typically located in the sellar or suprasellar region, and is a documented cause of oculomotor nerve palsy via compressive mechanisms.
Shaun Nevil, Umesh G, S Anton Charles, Sofia Mondal, Chaitra C S   +4 more
doaj   +1 more source

Chondroblastoma of the Clivus: Case Report and Review. [PDF]

, 2015
Background and Importance Chondroblastoma is a benign primary bone tumor that typically develops in the epiphyses of long bones. Chondroblastoma of the craniofacial skeleton is extremely rare, with most cases occurring in the squamosal portion of the ...
Ahmadpour, Arjang, Bewley, Arnaud F, Bobinski, Matthew, Lechpammer, Mirna, Liu, Jonathan, Shahlaie, Kiarash   +5 more
core   +1 more source

Imaging Findings in Neurogenic Ptosis

Journal of the Korean Society of Radiology
Neurogenic ptosis refers to upper eyelid drooping resulting from disrupted innervation of the eyelid retractor muscles. The differential diagnoses of neurogenic ptosis include oculomotor nerve palsy, Horner’s syndrome, and neuromuscular junction ...
Yiseul Son, Eun Ja Lee, Nam-Hee Kim, So Jeong Lee   +3 more
doaj   +1 more source

Cluster headache and intracranial aneurysm [PDF]

, 2007
In the present study we describe the cases of two patients with cluster-like headache related to intracranial carotid artery aneurysm. One of these patients responded to verapamil prescription with headache resolution. In both cases the surgical clipping
Carolina Martins, Laécio Leitão Batista, Luciana P. A. Andrade-Valença, Marcelo Moraes Valença, Maria Fátima Vasco de Aragão, Mario Fernando Prieto Peres, Wilson Farias da Silva   +6 more
core   +1 more source

Rapidly progressive atypical parkinsonism associated with frontotemporal lobar degeneration and motor neuron disease [PDF]

, 2010
Objective To report the rare but distinct clinical and neuropathological phenotype of non-familial, rapidly progressive parkinsonism and dementia associated with frontotemporal lobar degeneration with motor neuron disease (FTLD-MND).
de Courten-Myers, Gabrielle M., Espay, Alberto J., Ghetti, Bernardino, Houghton, David J., Litvan, Irene, Murrell, Jill R., Spina, Salvatore   +6 more
core   +1 more source

Congenital third nerve palsy with synergistic depression on attempted adduction and trigemino-oculomotor synkinesis: Underpinnings of a spectral dysinnervation disorder

Indian Journal of Ophthalmology, 2016
The authors describe a case of congenital partial pupil-sparing third cranial nerve palsy with absent adduction, synergistic depression of globe and widening of palpebral fissure on attempted adduction and synergistic elevation and adduction on mouth ...
Pramod Kumar Pandey, Vishaal Bhambhwani, P C Ranjith, Mandar Kadav, C Aparnaa   +4 more
doaj   +1 more source

Oculomotor nerve palsy following coronary artery bypass graft surgery: can pituitary apoplexy complicate the post-operative course of cardiac surgery? [PDF]

, 2021
Ali Alkhaibary, Noura Alsubaie, Ahoud Alharbi, Noor Alghanim, Sami Khairy, Makki Almuntashri, Mohammed Alwohaibi, Abdulaziz Alarifi, Ahmed Aloraidi, Ahmed Alkhani   +9 more
openalex   +1 more source

Oculomotor Synkinesis Secondary to Meningocele: Report of a Rare Case

Indian Journal of Radiology and Imaging
Oculomotor synkinesis or aberrant regeneration of cranial nerve III (CN III) typically results from trauma, aneurysm, or mass lesions. We present a rare case report with CN III palsy and synkinesis secondary to a meningocele in the left oculomotor ...
Benjamin Walker, Krishnakumari A. Modi, Leonardo F. Freitas, Nitesh Shekhrajka   +3 more
doaj   +1 more source

Heparin-Induced Pituitary Apoplexy Presenting as Isolated Unilateral Oculomotor Nerve Palsy: A Case Report and Literature Review

Case Reports in Endocrinology, 2019
Introduction. Pituitary apoplexy (PA) is a rare and potentially life-threatening clinical syndrome resulting from pituitary gland hemorrhage and/or infarction. Anticoagulation is a risk factor for triggering PA.
Bakr Swaid, Frank Kalaba, Ghassan Bachuwa, Stephen E. Sullivan   +3 more
doaj   +1 more source