Results 251 to 260 of about 6,414,238 (349)

SOX6 enhances vascular smooth muscle cell phenotypic switching and elevates blood pressure by activating autophagy

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Sox6 expression is elevated in hypertensive conditions and promotes vascular smooth muscle cell phenotypic switching through autophagy activation. Using gain‐ and loss‐of‐function approaches both in vitro and in vivo, we demonstrate that Sox6 regulates blood pressure and vascular remodeling, highlighting its potential as a novel therapeutic target for ...
Qianhui Ling   +7 more
wiley   +1 more source

The importance of exposure rate on odds ratios by cigarette smoking and alcohol consumption for esophageal adenocarcinoma and squamous cell carcinoma in the Barrett's Esophagus and Esophageal Adenocarcinoma Consortium [PDF]

open access: green, 2012
Jay H. Lubin   +22 more
openalex   +1 more source

Addressing Favorable and Challenging Flexible Plastic Packaging Waste Flows: A Material Flow Analysis

open access: yesJournal of Advanced Manufacturing and Processing, EarlyView.
ABSTRACT The majority of post‐consumer flexible plastic packaging (FPP) in the United States ends up in landfills and incinerators. This represents a significant material loss because FPP, also referred to as plastic films or foils, comprises up to half of all plastic packaging.
Oksana A. Makarova   +4 more
wiley   +1 more source

On the Mechanism of Soft Self‐Assembly from Melt: The Ubiquitous Heat Capacity Hump and Spontaneous Melt Chirality

open access: yesAngewandte Chemie, EarlyView.
Phase transition from melt to most complex liquid crystal (LC) phases is weak 1st order but is preceded by a large heat capacity maximum. In addition, a chiral liquid forms through another transition before that to the LC, despite the compounds being achiral.
Yi‐nan Xue   +9 more
wiley   +2 more sources

Association Between Vascular NOTCH3 Aggregation and Disease Severity in a CADASIL Cohort – Implications for NOTCH3 Variant‐Specific Disease Prediction

open access: yesAnnals of Neurology, EarlyView.
Objective Vascular NOTCH3 protein ectodomain aggregation is a pathological hallmark of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a monogenic small vessel disease typically caused by cysteine‐altering variants in NOTCH3.
Minne N. Cerfontaine   +10 more
wiley   +1 more source

Disease Characteristics and Treatments Associated with Outcome in Primary Angiitis of the Central Nervous System—A Multicenter Cohort Study in 163 Patients

open access: yesAnnals of Neurology, EarlyView.
Objective The aim was to determine patient, disease, and treatment characteristics associated with outcome in patients with primary angiitis of the central nervous system (PACNS) in a large multicenter German cohort. Methods In a retrospective, observational cohort study, we analyzed 163 adult patients who met the diagnostic criteria for PACNS.
Anna Lena Fisse   +29 more
wiley   +1 more source

The Role of Electroencephalography in Predicting Post‐Stroke Seizures and an Updated Prognostic Model (SeLECT‐EEG)

open access: yesAnnals of Neurology, EarlyView.
Objective Seizures negatively impact stroke outcomes, highlighting the need for reliable predictors of post‐stroke epilepsy. Although acute symptomatic seizures are a known risk factor, most stroke survivors who develop epilepsy do not experience them.
Kai Michael Schubert   +12 more
wiley   +1 more source

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