Results 141 to 150 of about 27,120 (259)

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

Data-driven, ML-assisted approaches to problem well-posedness. [PDF]

PNAS Nexus
Bertalan T, Kevrekidis GA, Koronaki ED, Mishra S, Rebrova E, Kevrekidis IG.   +5 more
europepmc   +1 more source

Feedback Linearisation with State Constraints

International Journal of Robust and Nonlinear Control, EarlyView.
ABSTRACT Feedback Linearisation (FBL) is a widely used technique that applies feedback laws to transform input‐affine nonlinear control systems into linear control systems, allowing for the use of linear controller design methods such as pole placement.
Songlin Jin, Yuanbo Nie, Morgan Jones
wiley   +1 more source

Coupled SDE-ODE Modeling of Tumor-Immune Dynamics to Infer Biomarker Release. [PDF]

Bull Math Biol
Shrestha P, Fan Y, George JT.
europepmc   +1 more source

Stair‐Climbing Wheelchairs for Enhanced Mobility: A Comprehensive Review of Fundamental Mechanisms, Design Concepts, and Performance Analysis

Journal of Field Robotics, EarlyView.
ABSTRACT People with physical disabilities face significant mobility challenges while climbing uneven surfaces and staircases. In these circumstances, traditional wheelchairs do not provide stable, safely controlled mobility, underscoring the importance of building superior stair‐climbing wheelchairs for both medical and infrastructure purposes.
Gopisetti Manikanta, S. M. Abhinandan, Anand Reddy, G. Chandana, Divya, P. Anil Kumar, Ch. Venkata Rao, Ashish Garg, Ravi C. Soni, Jogendra Kumar, Bhargav Akkinepally   +10 more
wiley   +1 more source

Automated Pharmacometric Model Development by Leveraging Low-Dimensional Neural ODEs and LASSO Regression. [PDF]

CPT Pharmacometrics Syst Pharmacol
Bräm DS, Steiert B, Steffens B, Pfister M, Koch G.   +4 more
europepmc   +1 more source

Hexapod Locomotion Across Structured and Unstructured Terrains: A Data‐Driven Review of Modeling, Control, and Validation

Journal of Field Robotics, EarlyView.
ABSTRACT The design of a hexapod is complex and requires integration between kinematic models, control systems, and sensing. Existing literature has reviewed these sub‐systems in isolation. Since 2021, there has been no review of the field despite significant advancements in soft soil, lunar traversal, and artificial intelligence.
Akhil Rampersad, Bashan Naidoo
wiley   +1 more source

iAODE for benchmarking and continuum modeling of single-cell chromatin accessibility. [PDF]

Commun Biol
Fu Z, Chen C, Wang S, Wang J, Chen S.
europepmc   +1 more source

Opportunities for Australia Amid China's Carbon‐Neutral Transition: Input–Output Approach With Analysis of Australian Renewable Potential

Sustainable Development, EarlyView.
ABSTRACT A major transformation in China's energy mix is underway as the country pursues carbon neutrality by 2060, posing significant structural challenges for Australia as a major exporter of carbon‐intensive resources. This study examines the economic impacts of China's decarbonisation on Australia by applying static and dynamic input–output (IO ...
Jinyong (Edward) Sung
wiley   +1 more source

Using multimodal imaging to improve the diagnostic accuracy and confidence in distinguishing non-arteritic anterior ischemic optic neuropathy from optic disc drusen. [PDF]

Front Neurol
Kim MY, Alkhabaz A, Yu M, Pujari R, Liao YJ.   +4 more
europepmc   +1 more source