Results 191 to 200 of about 62,374 (308)

iAODE for benchmarking and continuum modeling of single-cell chromatin accessibility. [PDF]

Commun Biol
Fu Z, Chen C, Wang S, Wang J, Chen S.
europepmc   +1 more source

Kinetics of ε‐Caprolactone Ring Opening Polymerization: Experimental and Modeling Study

Journal of Polymer Science, EarlyView.
We present a multi‐scale model for the ring‐opening polymerization of ε‐caprolactone to polycaprolactone (PCL), approximating final melt properties. We conducted batch experiments at various temperatures and reactant ratios. Using this data, we determined the kinetic parameters.
Jakub Staś, Milan Den Haese, Luca Cannas, Anton Ginzburg, Louis Pitet, Bart Van der Bruggen, Alexandr Zubov   +6 more
wiley   +1 more source

Using multimodal imaging to improve the diagnostic accuracy and confidence in distinguishing non-arteritic anterior ischemic optic neuropathy from optic disc drusen. [PDF]

Front Neurol
Kim MY, Alkhabaz A, Yu M, Pujari R, Liao YJ.   +4 more
europepmc   +1 more source

Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.
Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai, Jingchen Zhai, Beihong Ji, Fengyang Han, Taoyu Niu, Luxuan Wang, Junmei Wang   +6 more
wiley   +1 more source

Decomposable and Essentially Univariate Mass-Action Systems: Extensions of the Deficiency One Theorem. [PDF]

J Nonlinear Sci
Deshpande A, Müller S.
europepmc   +1 more source

Accelerating virtual patient generation with a Bayesian optimization and machine learning surrogate model

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 486-494, March 2025.
Abstract The pharmaceutical industry has increasingly adopted model‐informed drug discovery and development (MID3) to enhance productivity in drug discovery and development. Quantitative systems pharmacology (QSP), which integrates drug action mechanisms and disease complexities to predict clinical endpoints and biomarkers is central to MID3.
Hiroaki Iwata, Ryuta Saito
wiley   +1 more source

Qualia as control-theoretic constructs for autonomous agents: event phase space as an action-oriented semantic safety layer. [PDF]

Front Robot AI
Suvorov V.
europepmc   +1 more source

QSP Modeling Shows Pathological Synergism Between Insulin Resistance and Amyloid‐Beta Exposure in Upregulating VCAM1 Expression at the BBB Endothelium

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 561-571, March 2025.
ABSTRACT Type 2 diabetes mellitus (T2DM), characterized by insulin resistance, is closely associated with Alzheimer's disease (AD). Cerebrovascular dysfunction is manifested in both T2DM and AD, and is often considered as a pathological link between the two diseases.
Zengtao Wang, Vaishnavi Veerareddy, Xiaojiao Tang, Kevin J. Thompson, Sunil Krishnan, Krishna R. Kalari, Karunya K. Kandimalla   +6 more
wiley   +1 more source

Timing-controlled concept for extubation in brachycephalic dogs: α2-bridged on-demand extubation. [PDF]

Front Vet Sci
Nagahama S.
europepmc   +1 more source

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source