Results 1 to 10 of about 2,502 (163)

Metabolic rewiring enables ammonium assimilation via a non-canonical fumarate-based pathway. [PDF]

Microb Biotechnol
Glutamate is an abundant cellular metabolite that serves as a major donor of amino groups for the synthesis of nitrogen‐containing metabolites. Many bacteria can use either the glutamate dehydrogenase‐ or the glutamine synthetase/glutamate synthase‐dependent route for de novo synthesis of glutamate.
Mardoukhi MSY, Rapp J, Irisarri I, Gunka K, Link H, Marienhagen J, de Vries J, Stülke J, Commichau FM.   +8 more
europepmc   +2 more sources

The Brain-Gut Axis in Parkinson's Disease Pathology. [PDF]

Compr Physiol
Exposure to environmental toxins induces gut dysbiosis, increases intestinal epithelial barrier permeability, immune activation, and oxidative stress, promoting α‐syn misfolding and propagation. Brainstem DMV neurons exhibit α‐syn pathology, dysregulating neuronal excitability and vagal control of GI functions.
Ozkaya KS, Browning KN.
europepmc   +2 more sources

Stigma dan Diskriminasi Orang Dengan HIV/AIDS (ODHA) pada Pelayanan Kesehatan di Kota Pekanbaru Tahun 2014

Jurnal Kesehatan Komunitas (Journal of Community Health), 2014
Stigma dan diskriminasi masih sering terjadi pada orang dengan HIV/AIDS (ODHA). Wawancara yang dilakukan kepada beberapa orang yang bergerak di lembaga penggagas ODHA di kota Pekanbaru ( sebagian dari mereka adalah ODHA) mengatakan bahwa mereka pernah ...
Riri Maharani
exaly   +3 more sources

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy. [PDF]

Adv Healthc Mater
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Salim MW, Zhang W, Collins-Praino L, Wang Y, Care A.   +4 more
europepmc   +2 more sources

Logotherapy with the paradoxical intention technique to increase meaning in life and reduce hopelessness in people living with hiv/aids (ODHA) [PDF]

SHS Web of Conferences
HIV/AIDS is a condition that affects not only the physical aspects but also the psychological aspects, such as the emergence of hopelessness due to the loss of life’s meaning.
Ni'Matuzahroh Ni'Matuzahroh, Sri Juwita Kusumawardhani   +1 more
exaly   +2 more sources

Regulation of neural stem cells by innervating neurons. [PDF]

J Neurochem
To “build” the brain, neural stem and precursor cells (NPCs) first proliferate, and then differentiate into neurons and glia (astrocytes and oligodendrocytes) in a strict spatiotemporal manner. “Maintenance” of adult brain function requires a continuous generation of neurons and glia via adult NPCs, which are also required for replacement of damaged or
Dittmann NL, Chen L, Voronova A.
europepmc   +2 more sources

TINGKAT KEPATUHAN ODHA MINUM OBAT ARV DI POLI VCT MUTU MANIKAM RSUD DR H MOCH ANSARI SALEH BANJARMASIN

JIIS: Jurnal Ilmiah Ibnu Sina, 2021
Acquired Immunodeficiency Syndrome (AIDS) adalah sekumpulan gejala penyakit yang disebabkan oleh  Human Immunodeficiency Virus (HIV) yang merusak kekebalan tubuh.
Erna Prihandiwati, Novia Ariani, Yudi Hardi Susilo   +2 more
doaj   +3 more sources

Neuroprotective effects of a novel peptide from Lignosus rhinocerotis against 6‐hydroxydopamine‐induced apoptosis in PC12 cells by inhibiting NF‐κB activation

Food Science &Nutrition, Volume 11, Issue 5, Page 2152-2165, May 2023., 2023
In this study, a novel peptide (LRP) was extracted from the fruiting bodies of L. rhinocerotis using gel filtration chromatography. We determined the amino acid sequence of LRP, which was conducive to its artificial synthesis. Moreover, with NF‐κB as the target, the neuroprotective function of LRP was explored.
Chuan Xiong, Yu Zhu, Qiang Luo, Chia Wei Phan, Yujie Huo, Ping Li, Qiang Li, Xin Jin, Wenli Huang   +8 more
wiley   +1 more source

Changes to water management and declining pastoral resilience in Marsabit County, northern Kenya: The example of Gabra wells

WIREs Water, Volume 9, Issue 6, November/December 2022., 2022
Marsabit County, Kenya, and location of main well clusters (Map prepared by John Kinyangi, BIEA, Nairobi). Abstract In this article, we provide a review of research on the existing and abandoned wells in Marsabit County, Northern Kenya, and associated Indigenous Knowledge concerning water governance, institutions of leadership, and how these have ...
Freda Nkirote M'Mbogori, Mercy Gakii Kinyua, Ali Gufu Ibrae, Paul Jeremy Lane   +3 more
wiley   +1 more source

Metabolic engineering of microorganisms for the production of multifunctional non‐protein amino acids: γ‐aminobutyric acid and δ‐aminolevulinic acid

Microbial Biotechnology, Volume 14, Issue 6, Page 2279-2290, November 2021., 2021
For the first time, we put GABA and ALA together for a detailed summary, analysis and comparison, and put forward further strategies to meet the challenges of industrial competition strains. Summary Gamma‐aminobutyric acid (GABA) and delta‐aminolevulinic acid (ALA), playing important roles in agriculture, medicine and other fields, are multifunctional ...
Anping Su, Qijun Yu, Ying Luo, Jinshui Yang, Entao Wang, Hongli Yuan   +5 more
wiley   +1 more source