Results 51 to 60 of about 82,907,714 (218)
Advanced Science, EarlyView.ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao +5 more
wiley +1 more source
Strategies for Improving Police Response Models Involving Opioid Overdoses and Overdose Deaths
Journal of Multidisciplinary Studies in Human Rights and ScienceEN | Abstract: Deflection programs have emerged as a promising approach to addressing the opioid overdose crisis, offering an innovative alternative to traditional criminal justice approaches.
Thomas B. Sease +6 more
doaj +1 more source
Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy
Advanced Science, EarlyView.Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. Repurposed FDA‐approved drugs inhibit fungal PPTase (essential for secondary metabolism) in vivo.
Zili Song +7 more
wiley +1 more source
Preventing Substance Use-Related Crime through Deflection
Journal of Multidisciplinary Studies in Human Rights and ScienceEN | Abstract: This article examines deflection as a crime prevention strategy that focuses predominantly on preventing offenses related to substance use and co-occurring disorders. Applying decades of lessons learned in crime prevention, public health,
Guy Farina, Jac A. Charlier, Hope Fiori
doaj +1 more source
Contribuição institucional na promoção do aleitamento materno de mulheres trabalhadoras para o alcance dos Objetivos de Desenvolvimento Sustentável [PDF]
Revista Brasileira de Saúde OcupacionalResumo Introdução Os benefícios do aleitamento materno são cientificamente comprovados e recomendados, por promoverem a saúde não somente da criança, como da mãe.
Isis Leticia Brasil dos Santos +1 more
doaj +1 more source
Advanced Science, EarlyView.Modular zinc finger (ZF) metalloproteins function as programmable biomolecular scaffolds that modulate pathogenic amyloid assembly. Through direct protein–protein interactions, ZF arrays alter amyloid phase behavior and redirect β‐sheet fibrillization toward nontoxic aggregates.
Seongmin Park +16 more
wiley +1 more source
Incorporar els ODS a la docència: comencem pels TFG i TFM [vídeo]
, 2022 Participants: Joan Guàrdia, Montse Puig, Conxita Amat, Gustavo Llorente, Tere Sauras, Marco Rieckmann, Mar Grasa, Teresa Vadrí, Núria Sara Miras i Enric Pol.- Presentacions - Les podeu consultar a recurs relacionatLa formación de competencias clave para ...
Universitat de Barcelona. Vicerectorat d'Igualtat i Gènere
core +3 more sources
What It Takes: Implementation and Expansion of a Quick Response Team
Journal of Multidisciplinary Studies in Human Rights and ScienceEN | Abstract: Quick Response Teams (QRTs) have proliferated across the United States in response to the opioid overdose crisis. One of the first county-wide QRTs in the nation, the Hamilton County, Ohio QRT (HC-QRT), has been heralded as a model QRT ...
Sarah M. Manchak +5 more
doaj +1 more source
Advanced Intelligent Discovery, EarlyView.AI‐based tools enable rapid characterization of bacterial ultrastructure in low‐dose cryogenic transmission electron microscopy. The envelope thickness tool quantifies membrane thickness and anisotropy. The flagella module analyzes filament morphology and detects cell‐flagella contacts.
Sita Sirisha Madugula +10 more
wiley +1 more source
Revista Electrónica EducareObjetivo. Evaluar las percepciones del personal docente de I y II ciclo de la Educación General Básica en el año 2023 sobre el modelo de evaluación planteado por el Ministerio de Educación Pública de Costa Rica. Metodología.
Josiane Pawlowski +1 more
doaj +1 more source