Results 61 to 70 of about 114,901,315 (309)

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

open access: yesAdvanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao   +5 more
wiley   +1 more source

A formulação jurídica da política pública de saúde sob a perspectiva da agenda 2030 e o desenvolvimento sustentável

open access: yesRevista de Direito Econômico e Socioambiental
O presente estudo tem como finalidade analisar a interface entre o Objetivo de Desenvolvimento Sustentável 3 (ODS 3) da Agenda 2030 e a formulação jurídica da Política Pública de Saúde. O problema que norteia a pesquisa é identificar as diretrizes do ODS
Janriê Rodrigues Reck, Joice Schroer
doaj   +1 more source

ODS Iron Aluminides

open access: yes, 1995
Since oxide dispersion-strengthened (ODS) FeCrAl-based alloys have sufficient creep strength and good oxidation resistance at the very high temperatures of interest for the primary heat exchanger in advanced, closed-cycle gas turbine systems, they ...
Wright, I. G.   +2 more
core   +1 more source

Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy

open access: yesAdvanced Science, EarlyView.
Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. Repurposed FDA‐approved drugs inhibit fungal PPTase (essential for secondary metabolism) in vivo.
Zili Song   +7 more
wiley   +1 more source

Experiences of technology-rich innovation in European schools within the Open Discovery Space project

open access: yesEducation in the Knowledge Society, 2015
The Open Discovery Space (ODS) project was conceived to introduce innovative resource-based teaching and learning practices in European schools, to promote the creation of communities between European school members and to boost the demand for open ...
Sonia PEINADO   +13 more
doaj   +1 more source

Nostvum Scelus (Ode I, 3 d'Horace)

open access: yesRevue belge de philologie et d'histoire, 1936
info:eu-repo/semantics ...
openaire   +3 more sources

Emprendedores y ODS: compromisos y cooperación

open access: yes, 2022
Una segunda parte sobre Emprendedores en Acción y cómo aportar a los #ODS, junto a: - Víctor Hugo Malagón, Presidente del Foro de Presidentes - Fundador de #MACA Conduce: Ángela Gómez y Angélica Sánchez - Mauricio López, Director Ejecutivo de Pacto ...
Gómez Duque, Ángela María   +1 more
core  

Zinc Fingers as Programmable Metalloprotein Scaffolds for Altering Pathogenic Biomolecular Phase Transitions

open access: yesAdvanced Science, EarlyView.
Modular zinc finger (ZF) metalloproteins function as programmable biomolecular scaffolds that modulate pathogenic amyloid assembly. Through direct protein–protein interactions, ZF arrays alter amyloid phase behavior and redirect β‐sheet fibrillization toward nontoxic aggregates.
Seongmin Park   +16 more
wiley   +1 more source

RENZI SCORE FOR OBSTRUCTED DEFECATION SYNDROME - VALIDATION OF THE PORTUGUESE VERSION ACCORDING TO THE COSMIN CHECKLIST

open access: yesArquivos de Gastroenterologia
BACKGROUND: Recently, the Obstructed Defecation Syndrome score (ODS score) was developed and validated by Renzi to assess clinical staging and to allow evaluation and comparison of the efficacy of treatment of this disorder.
Ana Celia CAETANO   +3 more
doaj   +1 more source

Automated Bacterial Identification and Morphological Feature Analysis in Low‐Dose Cryo‐EM Using YOLOv11

open access: yesAdvanced Intelligent Discovery, EarlyView.
AI‐based tools enable rapid characterization of bacterial ultrastructure in low‐dose cryogenic transmission electron microscopy. The envelope thickness tool quantifies membrane thickness and anisotropy. The flagella module analyzes filament morphology and detects cell‐flagella contacts.
Sita Sirisha Madugula   +10 more
wiley   +1 more source

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