Results 131 to 140 of about 12,854,130 (226)

A genetic algorithm simheuristic for solving the stochastic project portfolio selection problem with portfolio reliability constraints

open access: yesInternational Transactions in Operational Research, Volume 33, Issue 6, Page 4039-4071, November 2026.
Abstract In response to the increasing complexity of modern products, dynamic markets, and intensified competition, project‐based organizations are actively seeking methodologies to efficiently manage their expanding project portfolios. This paper analyzes the project portfolio selection problem in uncertain environments. Despite recent advances in the
Miguel Saiz   +3 more
wiley   +1 more source

Resolution and Quantitation of Ribonucleosides and Deoxyribonucleosides in Digested Genomic DNA by UHPLC–MS/MS

open access: yesBiomedical Chromatography, Volume 40, Issue 10, October 2026.
ABSTRACT Deoxyuridine (dUrd) is often misincorporated into genomic DNA in cancer patients receiving antimetabolite chemotherapy. This activates base excision repair and recruits ataxia telangiectasia‐mutated and Rad3‐related (ATR), which coordinates DNA repair with nucleotide metabolism by facilitating ribonucleotide reductase (RNR) activity ...
Joshua J. Deppas   +5 more
wiley   +1 more source

Nicotinamide and Sodium Butyrate Double the Pool of Treatment‐Exclusive Metabolites in the Endophytic Fungus Curvularia sp. G6‐32

open access: yesChemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Epigenetic modulators nicotinamide and sodium butyrate reshape the chemical landscape of the endophytic fungus Curvularia sp. G6‐32. Combining the OSMAC strategy with UHPLC‐MS/MS metabolomics and molecular networking reveals a more than twofold rise in treatment‐exclusive metabolites, including diketopiperazines and potentially bioactive natural ...
Guilherme Edison Almeida Pega   +8 more
wiley   +1 more source

Bioactive Compounds and Cytotoxicity of Seed and Leaf Oils of Moringa oleifera

open access: yeseFood, Volume 7, Issue 5, October 2026.
Among the practical applications of the oils described in this study, their use as an ingredient in food stands out, as well as the potential for developing bioactive materials for packaging, conferring antioxidant and antimicrobial properties. Seed and leaf oils from Moringa oleifera exhibit functional properties of industrial interest and bioactive ...
Emanuela de Lima Viana   +12 more
wiley   +1 more source

Generation of Probiotic‐Based Multifunctional Hydrogels Capable of Carrying Oxygen and Anti‐Inflammatory Drugs and Their Effect on Cell Viability Under Hypoxic Conditions

open access: yesJournal of Biomedical Materials Research Part A, Volume 114, Issue 10, October 2026.
ABSTRACT Hypoxia and chronic inflammation have an interdependent relationship, as they stimulate each other. Under inflammation, hypoxia occurs in tissues and under hypoxia, transcription factors induce overproduction of pro‐inflammatory cytokines, causing the chronic inflammatory process.
Ulvi Suleymanzade   +4 more
wiley   +1 more source

Educação Digital: o acesso digital para o Objetivo de Desenvolvimento Sustentável 4 (ODS 4) [PDF]

open access: yes
A presente pesquisa tem por tema o acesso digital como instrumento emancipador da sustentabilidade e da educação, tendo em vista que a educação inclusiva, equitativa e de qualidade foi fixada como objetivo autônomo no âmbito da Agenda 2030.
Leviski, Daiane Schneider   +1 more
core  

Classification of Odontogenic Sinusitis: A Clinical‐Based Phenotyping System to Guide Multidisciplinary Surgical Management

open access: yesLaryngoscope Investigative Otolaryngology, Volume 11, Issue 5, October 2026.
ABSTRACT Background Odontogenic sinusitis (ODS) is a condition that requires a multidisciplinary approach for successful treatment. Effective communication among the healthcare providers involved reduces the risk of errors and treatment failure. This study proposes a new ODS classification system to facilitate the communication of pivotal clinical ...
Lorenzo Sabatino   +8 more
wiley   +1 more source

Assessment of Monomer Release From Resin Composites Following the Use of Various Modeling Liquids

open access: yesJournal of Esthetic and Restorative Dentistry, Volume 38, Issue 10, Page 1933-1946, October 2026.
ABSTRACT Objectives The chemical composition of resin composites and the use of modeling liquids may influence the release of residual monomer, potentially impacting biocompatibility. This in vitro study evaluated the effect of different modeling liquids on the elution of monomers from two resin composites.
Dorukcan Yıldırım   +3 more
wiley   +1 more source

Successive Azide and DNA Functionalization for Reversible and Controlled Association of Single‐Wall Carbon Nanotubes

open access: yesChemistry – A European Journal, Volume 32, Issue 35, 19 September 2026.
A newly synthesized bifunctional azide—diazonium linker allows robust one‐step introduction of azido groups to single‐wall carbon nanotubes. Versatility of the azido groups as reactive handles is demonstrated by further derivatization with 6‐carboxyfluorescein and oligonucleotides.
Razieh Moosavi   +6 more
wiley   +1 more source

METTL18 is Required for Developmental, Metabolic, and Endocrine Regulation of Mammalian Growth

open access: yesThe FASEB Journal, Volume 40, Issue 17, 15 September 2026.
METTL18 is essential for histidine Nτ‐methylation of proteins, normal embryonic development, iron and lipid metabolism, and hormone signaling pathways that support postnatal growth in mice. The main points of this study are as follows: First, mouse METTL18 catalyzes histidine Nτ‐methylation. Next, Mettl18 KO embryos are significantly smaller than their
Fumiya Kasai   +16 more
wiley   +1 more source

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