Results 261 to 270 of about 247,095 (344)

Science of omics: a molecular space odyssey

Experimental Physiology, EarlyView.
Salomé Coppens, Christophe Hirtz, Margaux Vignon, Damian M. Bailey   +3 more
wiley   +1 more source

Minor epic: Notes toward a different “Anthropoetry”

Anthropology and Humanism, Volume 51, Issue 1, June 2026.
Abstract Anthropologists have often turned to poetry as a means of accessing emotional registers of which conventional academic prose is unable to avail. In doing so, they have tacitly conflated poetry with lyric poetry, today probably the most widely practiced poetic genre, associated in particular with the expression of inner feelings and subjectival
Stuart McLean
wiley   +1 more source

PCSK9 targeting therapies for familial hypercholesterolaemia: a meta-analysis of efficacy on lipid biomarkers and safety in adults and children across 23 RCTs. [PDF]

Open Heart
Ho VQT, Tran NB, Nguyen N, Arrighini GS, Downes D, Dandamudi M, Ferrara VZ, Ho THQ, Walia H, Barbagelata A, Leucker TM, Giorgi J.   +11 more
europepmc   +1 more source

Hyperaldosteronism in Mice Lacking the Distal Polybasic Tract of the γ‐Subunit of the Epithelial Sodium Channel During Sodium Restriction

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aims The epithelial sodium channel ENaC consists of the subunits α, β, and γ and is activated at an individual channel level by proteolytic processing. Murine γENaC contains a distal polybasic tract 186RKRK mediating proteolytic ENaC activation by serine proteases in vitro.
Daniel Essigke, M. Zaher Kalo, Matthias Wörn, Xia‐Qing Li, Bernhard N. Bohnert, Anja Schork, Andreas L. Birkenfeld, Thomas Ott, Ferruh Artunc   +8 more
wiley   +1 more source

Therapeutic Potential of PCSK9 Inhibitors in Regulating Neuroinflammation in Acute Ischemic Stroke. [PDF]

CNS Drugs
Pu L, Liu J, Kong S, Joyama Y, Gong X, Ji X, Dong H.   +6 more
europepmc   +1 more source

Sus1 Modulates Chromatin Remodeling and Gene Expression via the Cell Wall Integrity Pathway in Saccharomyces cerevisiae

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
Cell wall stress in yeast triggers transcriptional reprogramming through the CWI pathway. This study identifies Sus1, a subunit of SAGA and TREX‐2, as a key regulator in this process. Sus1 associates with stress‐responsive genes, promoting pre‐initiation complex assembly, chromatin remodeling, and RNA Pol II progression independently of H2B ...
Mónica Pavón‐Vergés, Raúl García, José M. Rodríguez‐Peña, Ana Belén Sanz, Javier Arroyo   +4 more
wiley   +1 more source

Determinants of circulating PCSK9 levels and the efficacy of PCSK9 inhibitor therapies in chronic kidney disease: a systematic review. [PDF]

Eur J Clin Pharmacol
Ábel T, Benczúr B, Csajbókné ÉC.
europepmc   +1 more source

Monoclonal Antibodies Accessing the Cytosol of Living Cells and Binding to Polo‐Like Kinase 1 Interdomain Linker Affect Mitotic Behavior

ChemBioChem, Volume 27, Issue 9, 14 May 2026.
Monoclonal antibodies targeting the interdomain region of polo‐like kinase 1 (PLK1) were delivered into living HeLa cells by electroporation to directly modulate mitotic progression. This intracellular antibody approach provides a new tool to probe PLK1 function and highlights the potential of antibodies to regulate key mitotic regulators inside cells.
Clément Steyer, Jean-Christophe Amé, Mariel Donzeau, Karie Shen, Manuela Chiper, Guy Zuber   +5 more
wiley   +1 more source

Indirect comparison of the efficacy and safety of alirocumab and evolocumab on major cardiovascular events: a systematic review and network meta-analysis. [PDF]

Front Pharmacol
Xu L, Lei M, Li L, Li Y, Gu C, Zheng P.
europepmc   +1 more source

Denial of Inpatient Genetic Testing: A Study on Outpatient Yield and Outcomes

American Journal of Medical Genetics Part A, Volume 200, Issue 5, Page 1044-1054, May 2026.
ABSTRACT Genetic conditions suspected in children often require genetic testing for accurate diagnoses, but testing remains costly. Case management teams review genetic test requests to improve access for patients while reducing the financial burden for medical institutions.
Cindy Y. Canales, Kathleen Shields, Meagan Choates, Paul Hillman, Laura Farach, Theresa Wittman, Kathryn Leal   +6 more
wiley   +1 more source